{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:39:16Z","timestamp":1774312756939,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,5,22]],"date-time":"2005-05-22T00:00:00Z","timestamp":1116720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,5,22]],"date-time":"2005-05-22T00:00:00Z","timestamp":1116720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1038\/nn1470","type":"journal-article","created":{"date-parts":[[2005,5,22]],"date-time":"2005-05-22T17:09:14Z","timestamp":1116781754000},"page":"813-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Instructive signals for motor learning from visual cortical area MT"],"prefix":"10.1038","volume":"8","author":[{"given":"Megan R","family":"Carey","sequence":"first","affiliation":[]},{"given":"Javier F","family":"Medina","sequence":"additional","affiliation":[]},{"given":"Stephen G","family":"Lisberger","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,5,22]]},"reference":[{"key":"BFnn1470_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev.neuro.23.1.473","volume":"23","author":"W Schultz","year":"2000","unstructured":"Schultz, W. & Dickinson, A. Neuronal coding of prediction errors. Annu. Rev. Neurosci. 23, 473\u2013500 (2000).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn1470_CR2","first-page":"64","volume-title":"Classical Conditioning II: Current Research and Theory","author":"RA Rescorla","year":"1972","unstructured":"Rescorla, R.A. & Wagner, A.R. A theory of pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement. in Classical Conditioning II: Current Research and Theory (eds. Black, A.H. & Prokasy, W.F.) 64\u201399 (Appleton Century Crofts, New York, 1972)."},{"key":"BFnn1470_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0006-8993(72)90110-2","volume":"40","author":"M Ito","year":"1972","unstructured":"Ito, M. Neural design of the cerebellar motor control system. Brain Res. 40, 81\u201384 (1972).","journal-title":"Brain Res."},{"key":"BFnn1470_CR4","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1113\/jphysiol.1961.sp006811","volume":"159","author":"C Rashbass","year":"1961","unstructured":"Rashbass, C. The relationship between saccadic and smooth tracking eye movements. J. Physiol. (Lond.) 159, 326\u2013338 (1961).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn1470_CR5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1113\/jphysiol.1965.sp007718","volume":"180","author":"DA Robinson","year":"1965","unstructured":"Robinson, D.A. The mechanics of human smooth pursuit eye movement. J. Physiol. (Lond.) 180, 569\u2013591 (1965).","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnn1470_CR6","doi-asserted-by":"publisher","first-page":"7270","DOI":"10.1523\/JNEUROSCI.16-22-07270.1996","volume":"16","author":"M Kahlon","year":"1996","unstructured":"Kahlon, M. & Lisberger, S.G. Coordinate system for learning in the smooth pursuit eye movements of monkeys. J. Neurosci. 16, 7270\u20137283 (1996).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.neuron.2004.12.017","volume":"45","author":"JF Medina","year":"2005","unstructured":"Medina, J.F., Carey, M.R. & Lisberger, S.G. The representation of time for motor learning. Neuron 45, 157\u2013167 (2005).","journal-title":"Neuron"},{"key":"BFnn1470_CR8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/0042-6989(92)90184-K","volume":"32","author":"DK Boman","year":"1992","unstructured":"Boman, D.K. & Hotson, J.R. Predictive smooth pursuit eye movements near abrupt changes in motion direction. Vision Res. 32, 675\u2013689 (1992).","journal-title":"Vision Res."},{"key":"BFnn1470_CR9","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1152\/jn.1983.49.5.1127","volume":"49","author":"JH Maunsell","year":"1983","unstructured":"Maunsell, J.H. & Van Essen, D.C. Functional properties of neurons in middle temporal visual area of the macaque monkey. I. Selectivity for stimulus direction, speed, and orientation. J. Neurophysiol. 49, 1127\u20131147 (1983).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR10","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1152\/jn.1984.52.6.1106","volume":"52","author":"TD Albright","year":"1984","unstructured":"Albright, T.D. Direction and orientation selectivity of neurons in visual area MT of the macaque. J. Neurophysiol. 52, 1106\u20131130 (1984).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR11","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1523\/JNEUROSCI.05-03-00825.1985","volume":"5","author":"WT Newsome","year":"1985","unstructured":"Newsome, W.T., Wurtz, R.H., Dursteler, M.R. & Mikami, A. Deficits in visual motion processing following ibotenic acid lesions of the middle temporal visual area of the macaque monkey. J. Neurosci. 5, 825\u2013840 (1985).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR12","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1152\/jn.1988.60.2.604","volume":"60","author":"WT Newsome","year":"1988","unstructured":"Newsome, W.T., Wurtz, R.H. & Komatsu, H. Relation of cortical areas MT and MST to pursuit eye movements II. Differentiation of retinal from extraretinal inputs. J. Neurophysiol. 60, 604\u2013620 (1988).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR13","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1523\/JNEUROSCI.19-06-02224.1999","volume":"19","author":"SG Lisberger","year":"1999","unstructured":"Lisberger, S.G. & Movshon, J.A. Visual motion analysis for pursuit eye movements in area MT of macaque monkeys. J. Neurosci. 19, 2224\u20132246 (1999).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1152\/jn.1989.62.1.31","volume":"62","author":"H Komatsu","year":"1989","unstructured":"Komatsu, H. & Wurtz, R.H. Modulation of pursuit eye movements by stimulation of cortical areas MT and MST. J. Neurophysiol. 62, 31\u201347 (1989).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR15","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1523\/JNEUROSCI.17-11-04312.1997","volume":"17","author":"JM Groh","year":"1997","unstructured":"Groh, J.M., Born, R.T. & Newsome, W.T. How is a sensory map read out? Effects of microstimulation in visual area MT on saccades and smooth pursuit eye movements. J. Neurosci. 17, 4312\u20134330 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR16","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1523\/JNEUROSCI.12-06-02331.1992","volume":"12","author":"CD Salzman","year":"1992","unstructured":"Salzman, C.D., Murasugi, C.M., Britten, K.H. & Newsome, W.T. Microstimulation in visual area MT: effects on direction discrimination performance. J. Neurosci. 12, 2331\u20132355 (1992).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1152\/jn.2001.85.1.187","volume":"85","author":"JW Bisley","year":"2001","unstructured":"Bisley, J.W., Zaksas, D. & Pasternak, T. Microstimulation of cortical area MT affects performance on a visual working memory task. J. Neurophysiol. 85, 187\u2013196 (2001).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR18","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1152\/jn.01079.2003","volume":"91","author":"Y Kodaka","year":"2004","unstructured":"Kodaka, Y., Miura, K., Suehiro, K., Takemura, A. & Kawano, K. Ocular tracking of moving targets: effects of perturbing the background. J. Neurophysiol. 91, 2474\u20132483 (2004).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR19","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1152\/jn.1998.79.6.3272","volume":"79","author":"MT Schmolesky","year":"1998","unstructured":"Schmolesky, M.T. et al. Signal timing across the macaque visual system. J. Neurophysiol. 79, 3272\u20133278 (1998).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR20","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1152\/jn.1999.82.4.1944","volume":"82","author":"SE Raiguel","year":"1999","unstructured":"Raiguel, S.E., Xiao, D.K., Marcar, V.L. & Orban, G.A. Response latency of macaque area MT\/V5 neurons and its relationship to stimulus parameters. J. Neurophysiol. 82, 1944\u20131956 (1999).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR21","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/nn924","volume":"5","author":"EP Cook","year":"2002","unstructured":"Cook, E.P. & Maunsell, J.H. Dynamics of neuronal responses in macaque MT and VIP during motion detection. Nat. Neurosci. 5, 985\u2013994 (2002).","journal-title":"Nat. Neurosci."},{"key":"BFnn1470_CR22","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1523\/JNEUROSCI.22-08-03189.2002","volume":"22","author":"W Bair","year":"2002","unstructured":"Bair, W., Cavanaugh, J.R., Smith, M.A. & Movshon, J.A. The timing of response onset and offset in macaque visual neurons. J. Neurosci. 22, 3189\u20133205 (2002).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR23","doi-asserted-by":"publisher","first-page":"5349","DOI":"10.1073\/pnas.83.14.5349","volume":"83","author":"MD Mauk","year":"1986","unstructured":"Mauk, M.D., Steinmetz, J.E. & Thompson, R.F. Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc. Natl. Acad. Sci. USA 83, 5349\u20135353 (1986).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnn1470_CR24","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1152\/jn.2001.86.4.1555","volume":"86","author":"SK Talwar","year":"2001","unstructured":"Talwar, S.K. & Gerstein, G.L. Reorganization in awake rat auditory cortex by local microstimulation and its effect on frequency-discrimination behavior. J. Neurophysiol. 86, 1555\u20131572 (2001).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR25","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/0042-6989(89)90052-7","volume":"29","author":"E Kowler","year":"1989","unstructured":"Kowler, E. Cognitive expectations, not habits, control anticipatory smooth oculomotor pursuit. Vision Res. 29, 1049\u20131057 (1989).","journal-title":"Vision Res."},{"key":"BFnn1470_CR26","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nature01341","volume":"421","author":"T Moore","year":"2003","unstructured":"Moore, T. & Armstrong, K.M. Selective gating of visual signals by microstimulation of frontal cortex. Nature 421, 370\u2013373 (2003).","journal-title":"Nature"},{"key":"BFnn1470_CR27","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1523\/JNEUROSCI.0172-04.2004","volume":"24","author":"IH Chou","year":"2004","unstructured":"Chou, I.H. & Lisberger, S.G. The role of the frontal pursuit area in learning in smooth pursuit eye movements. J. Neurosci. 24, 4124\u20134133 (2004).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR28","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1152\/jn.2000.84.6.2945","volume":"84","author":"M Kahlon","year":"2000","unstructured":"Kahlon, M. & Lisberger, S.G. Changes in the responses of Purkinje cells in the floccular complex of monkeys after motor learning in smooth pursuit eye movements. J. Neurophysiol. 84, 2945\u20132960 (2000).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR29","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/cne.10127","volume":"444","author":"C Distler","year":"2002","unstructured":"Distler, C., Mustari, M.J. & Hoffmann, K.P. Cortical projections to the nucleus of the optic tract and dorsal terminal nucleus and to the dorsolateral pontine nucleus in macaques: a dual retrograde tracing study. J. Comp. Neurol. 444, 144\u2013158 (2002).","journal-title":"J. Comp. Neurol."},{"key":"BFnn1470_CR30","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/0006-8993(75)90375-3","volume":"98","author":"K Alley","year":"1975","unstructured":"Alley, K., Baker, R. & Simpson, J.I. Afferents to the vestibulo-cerebellum and the origin of the visual climbing fibers in the rabbit. Brain Res. 98, 582\u2013589 (1975).","journal-title":"Brain Res."},{"key":"BFnn1470_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0306-4522(79)90082-4","volume":"4","author":"P Brodal","year":"1979","unstructured":"Brodal, P. The pontocerebellar projection in the rhesus monkey: an experimental study with retrograde axonal transport of horseradish peroxidase. Neuroscience 4, 193\u2013208 (1979).","journal-title":"Neuroscience"},{"key":"BFnn1470_CR32","doi-asserted-by":"publisher","first-page":"9112","DOI":"10.1523\/JNEUROSCI.18-21-09112.1998","volume":"18","author":"JL Raymond","year":"1998","unstructured":"Raymond, J.L. & Lisberger, S.G. Neural learning rules for the vestibulo-ocular reflex. J. Neurosci. 18, 9112\u20139129 (1998).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0959-4388(00)00154-9","volume":"10","author":"JF Medina","year":"2000","unstructured":"Medina, J.F., Nores, W.L., Ohyama, T. & Mauk, M.D. Mechanisms of cerebellar learning suggested by eyelid conditioning. Curr. Opin. Neurobiol. 10, 717\u2013724 (2000).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn1470_CR34","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/387278a0","volume":"387","author":"CC Bell","year":"1997","unstructured":"Bell, C.C., Han, V.Z., Sugawara, Y. & Grant, K. Synaptic plasticity in a cerebellum-like structure depends on temporal order. Nature 387, 278\u2013281 (1997).","journal-title":"Nature"},{"key":"BFnn1470_CR35","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1038\/81792","volume":"3","author":"SS Wang","year":"2000","unstructured":"Wang, S.S., Denk, W. & Hausser, M. Coincidence detection in single dendritic spines mediated by calcium release. Nat. Neurosci. 3, 1266\u20131273 (2000).","journal-title":"Nat. Neurosci."},{"key":"BFnn1470_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1101\/lm.2.3-4.185","volume":"2","author":"C Chen","year":"1995","unstructured":"Chen, C. & Thompson, R.F. Temporal specificity of long-term depression in parallel fiber\u2013Purkinje synapses in rat cerebellar slice. Learn. Mem. 2, 185\u2013198 (1995).","journal-title":"Learn. Mem."},{"key":"BFnn1470_CR37","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.neuron.2004.12.045","volume":"45","author":"SD Brenowitz","year":"2005","unstructured":"Brenowitz, S.D. & Regehr, W.G. Associative short-term synaptic plasticity mediated by endocannabinoids. Neuron 45, 419\u2013431 (2005).","journal-title":"Neuron"},{"key":"BFnn1470_CR38","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S0165-0173(99)00040-5","volume":"31","author":"FA Middleton","year":"2000","unstructured":"Middleton, F.A. & Strick, P.L. Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res. Brain Res. Rev. 31, 236\u2013250 (2000).","journal-title":"Brain Res. Brain Res. Rev."},{"key":"BFnn1470_CR39","doi-asserted-by":"publisher","first-page":"9233","DOI":"10.1523\/JNEUROSCI.17-23-09233.1997","volume":"17","author":"JR Tian","year":"1997","unstructured":"Tian, J.R. & Lynch, J.C. Subcortical input to the smooth and saccadic eye movement subregions of the frontal eye field in Cebus monkey. J. Neurosci. 17, 9233\u20139247 (1997).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR40","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/S0959-4388(00)00153-7","volume":"10","author":"K Doya","year":"2000","unstructured":"Doya, K. Complementary roles of basal ganglia and cerebellum in learning and motor control. Curr. Opin. Neurobiol. 10, 732\u2013739 (2000).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn1470_CR41","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0959-4388(02)00307-0","volume":"12","author":"O Hikosaka","year":"2002","unstructured":"Hikosaka, O., Nakamura, K., Sakai, K. & Nakahara, H. Central mechanisms of motor skill learning. Curr. Opin. Neurobiol. 12, 217\u2013222 (2002).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnn1470_CR42","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1152\/jn.1997.77.3.1325","volume":"77","author":"M Jueptner","year":"1997","unstructured":"Jueptner, M., Frith, C.D., Brooks, D.J., Frackowiak, R.S. & Passingham, R.E. Anatomy of motor learning. II. Subcortical structures and learning by trial and error. J. Neurophysiol. 77, 1325\u20131337 (1997).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR43","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1152\/jn.00525.2003","volume":"91","author":"MR Carey","year":"2004","unstructured":"Carey, M.R. & Lisberger, S.G. Signals that modulate gain control for smooth pursuit eye movements in monkeys. J. Neurophysiol. 91, 623\u2013631 (2004).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR44","doi-asserted-by":"publisher","first-page":"9387","DOI":"10.1523\/JNEUROSCI.21-23-09387.2001","volume":"21","author":"MM Churchland","year":"2001","unstructured":"Churchland, M.M. & Lisberger, S.G. Shifts in the population response in the middle temporal visual area parallel perceptual and motor illusions produced by apparent motion. J. Neurosci. 21, 9387\u20139402 (2001).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR45","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1152\/jn.1987.58.6.1351","volume":"58","author":"EJ Morris","year":"1987","unstructured":"Morris, E.J. & Lisberger, S.G. Different responses to small visual errors during initiation and maintenance of smooth-pursuit eye movements in monkeys. J. Neurophysiol. 58, 1351\u20131369 (1987).","journal-title":"J. Neurophysiol."},{"key":"BFnn1470_CR46","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1523\/JNEUROSCI.13-04-01719.1993","volume":"13","author":"CM Murasugi","year":"1993","unstructured":"Murasugi, C.M., Salzman, C.D. & Newsome, W.T. Microstimulation in visual area MT: effects of varying pulse amplitude and frequency. J. Neurosci. 13, 1719\u20131729 (1993).","journal-title":"J. Neurosci."},{"key":"BFnn1470_CR47","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0896-6273(00)81208-8","volume":"26","author":"RT Born","year":"2000","unstructured":"Born, R.T., Groh, J.M., Zhao, R. & Lukasewycz, S.J. Segregation of object and background motion in visual area MT: effects of microstimulation on eye movements. Neuron 26, 725\u2013734 (2000).","journal-title":"Neuron"}],"updated-by":[{"DOI":"10.1038\/nn0705-969b","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000}}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn1470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1470","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn1470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:54:57Z","timestamp":1684454097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn1470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,22]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6,1]]}},"alternative-id":["BFnn1470"],"URL":"https:\/\/doi.org\/10.1038\/nn1470","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/nn0705-969b","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,22]]},"assertion":[{"value":"1 February 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}