{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:00:58Z","timestamp":1776520858620,"version":"3.51.2"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,2,10]],"date-time":"2008-02-10T00:00:00Z","timestamp":1202601600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Neurosci"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1038\/nn2048","type":"journal-article","created":{"date-parts":[[2008,2,10]],"date-time":"2008-02-10T13:52:03Z","timestamp":1202651523000},"page":"327-333","source":"Crossref","is-referenced-by-count":256,"title":["Control of visually guided behavior by distinct populations of spinal projection neurons"],"prefix":"10.1038","volume":"11","author":[{"given":"Michael B","family":"Orger","sequence":"first","affiliation":[]},{"given":"Adam R","family":"Kampff","sequence":"additional","affiliation":[]},{"given":"Kristen E","family":"Severi","sequence":"additional","affiliation":[]},{"given":"Johann H","family":"Bollmann","sequence":"additional","affiliation":[]},{"given":"Florian","family":"Engert","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,2,10]]},"reference":[{"key":"BFnn2048_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198524052.001.0001","volume-title":"Neuronal Control of Locomotion","author":"GN Orlovsky","year":"1999","unstructured":"Orlovsky, G.N., Deliagina, T.G. & Grillner, S. Neuronal Control of Locomotion (Oxford University Press, New York, 1999)."},{"key":"BFnn2048_CR2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1152\/physrev.00028.2005","volume":"86","author":"S Rossignol","year":"2006","unstructured":"Rossignol, S., Dubuc, R.J. & Gossard, J.P. Dynamic sensorimotor interactions in locomotion. Physiol. Rev. 86, 89\u2013154 (2006).","journal-title":"Physiol. Rev."},{"key":"BFnn2048_CR3","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1111\/j.1460-9568.2005.04395.x","volume":"22","author":"PV Zelenin","year":"2005","unstructured":"Zelenin, P.V. Activity of individual reticulospinal neurons during different forms of locomotion in the lamprey. Eur. J. Neurosci. 22, 2271\u20132282 (2005).","journal-title":"Eur. J. Neurosci."},{"key":"BFnn2048_CR4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/S0165-0173(02)00199-6","volume":"40","author":"TG Deliagina","year":"2002","unstructured":"Deliagina, T.G., Zelenin, P.V. & Orlovsky, G.N. Encoding and decoding of reticulospinal commands. Brain Res. Brain Res. Rev. 40, 166\u2013177 (2002).","journal-title":"Brain Res. Brain Res. Rev."},{"key":"BFnn2048_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuron.2005.05.019","volume":"47","author":"H Korn","year":"2005","unstructured":"Korn, H. & Faber, D.S. The Mauthner cell half a century later: a neurobiological model for decision-making? Neuron 47, 13\u201328 (2005).","journal-title":"Neuron"},{"key":"BFnn2048_CR6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/neu.20000","volume":"59","author":"E Gahtan","year":"2004","unstructured":"Gahtan, E. & Baier, H. Of lasers, mutants and see-through brains: functional neuroanatomy in zebrafish. J. Neurobiol. 59, 147\u2013161 (2004).","journal-title":"J. Neurobiol."},{"key":"BFnn2048_CR7","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S","volume":"37","author":"L Saint-Amant","year":"1998","unstructured":"Saint-Amant, L. & Drapeau, P. Time course of the development of motor behaviors in the zebrafish embryo. J. Neurobiol. 37, 622\u2013632 (1998).","journal-title":"J. Neurobiol."},{"key":"BFnn2048_CR8","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1242\/jeb.203.17.2565","volume":"203","author":"SA Budick","year":"2000","unstructured":"Budick, S.A. & O'Malley, D.M. Locomotor repertoire of the larval zebrafish: swimming, turning and prey capture. J. Exp. Biol. 203, 2565\u20132579 (2000).","journal-title":"J. Exp. Biol."},{"key":"BFnn2048_CR9","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1242\/jeb.003939","volume":"210","author":"HA Burgess","year":"2007","unstructured":"Burgess, H.A. & Granato, M. Modulation of locomotor activity in larval zebrafish during light adaptation. J. Exp. Biol. 210, 2526\u20132539 (2007).","journal-title":"J. Exp. Biol."},{"key":"BFnn2048_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/cne.902050203","volume":"205","author":"CB Kimmel","year":"1982","unstructured":"Kimmel, C.B., Powell, S.L. & Metcalfe, W.K. Brain neurons which project to the spinal cord in young larvae of the zebrafish. J. Comp. Neurol. 205, 112\u2013127 (1982).","journal-title":"J. Comp. Neurol."},{"key":"BFnn2048_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/cne.903040104","volume":"304","author":"RK Lee","year":"1991","unstructured":"Lee, R.K. & Eaton, R.C. Identifiable reticulospinal neurons of the adult zebrafish, Brachydanio rerio. J. Comp. Neurol. 304, 34\u201352 (1991).","journal-title":"J. Comp. Neurol."},{"key":"BFnn2048_CR12","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/S0896-6273(00)80246-9","volume":"17","author":"DM O'Malley","year":"1996","unstructured":"O'Malley, D.M., Kao, Y.H. & Fetcho, J.R. Imaging the functional organization of zebrafish hindbrain segments during escape behaviors. Neuron 17, 1145\u20131155 (1996).","journal-title":"Neuron"},{"key":"BFnn2048_CR13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/cne.902510202","volume":"251","author":"WK Metcalfe","year":"1986","unstructured":"Metcalfe, W.K., Mendelson, B. & Kimmel, C.B. Segmental homologies among reticulospinal neurons in the hindbrain of the zebrafish larva. J. Comp. Neurol. 251, 147\u2013159 (1986).","journal-title":"J. Comp. Neurol."},{"key":"BFnn2048_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/cne.10621","volume":"459","author":"E Gahtan","year":"2003","unstructured":"Gahtan, E. & O'Malley, D.M. Visually guided injection of identified reticulospinal neurons in zebrafish: a survey of spinal arborization patterns. J. Comp. Neurol. 459, 186\u2013200 (2003).","journal-title":"J. Comp. Neurol."},{"key":"BFnn2048_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-8993(90)91012-6","volume":"517","author":"J Nissanov","year":"1990","unstructured":"Nissanov, J., Eaton, R.C. & DiDomenico, R. The motor output of the Mauthner cell, a reticulospinal command neuron. Brain Res. 517, 88\u201398 (1990).","journal-title":"Brain Res."},{"key":"BFnn2048_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0896-6273(00)80783-7","volume":"23","author":"KS Liu","year":"1999","unstructured":"Liu, K.S. & Fetcho, J.R. Laser ablations reveal functional relationships of segmental hindbrain neurons in zebrafish. Neuron 23, 325\u2013335 (1999).","journal-title":"Neuron"},{"key":"BFnn2048_CR17","doi-asserted-by":"publisher","first-page":"4984","DOI":"10.1523\/JNEUROSCI.0615-07.2007","volume":"27","author":"HA Burgess","year":"2007","unstructured":"Burgess, H.A. & Granato, M. Sensorimotor gating in larval zebrafish. J. Neurosci. 27, 4984\u20134994 (2007).","journal-title":"J. Neurosci."},{"key":"BFnn2048_CR18","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1152\/jn.00596.2001","volume":"87","author":"E Gahtan","year":"2002","unstructured":"Gahtan, E., Sankrithi, N., Campos, J.B. & O'Malley, D.M. Evidence for a widespread brain stem escape network in larval zebrafish. J. Neurophysiol. 87, 608\u2013614 (2002).","journal-title":"J. Neurophysiol."},{"key":"BFnn2048_CR19","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1126\/science.1103736","volume":"307","author":"KL Briggman","year":"2005","unstructured":"Briggman, K.L., Abarbanel, H.D. & Kristan, W.B., Jr. Optical imaging of neuronal populations during decision-making. Science 307, 896\u2013901 (2005).","journal-title":"Science"},{"key":"BFnn2048_CR20","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1126\/science.8303300","volume":"263","author":"JY Wu","year":"1994","unstructured":"Wu, J.Y., Cohen, L.B. & Falk, C.X. Neuronal activity during different behaviors in Aplysia: a distributed organization? Science 263, 820\u2013823 (1994).","journal-title":"Science"},{"key":"BFnn2048_CR21","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/cne.1352","volume":"439","author":"TJ Bosch","year":"2001","unstructured":"Bosch, T.J., Maslam, S. & Roberts, B.L. Fos-like immunohistochemical identification of neurons active during the startle response of the rainbow trout. J. Comp Neurol. 439, 306\u2013314 (2001).","journal-title":"J. Comp Neurol."},{"key":"BFnn2048_CR22","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1523\/JNEUROSCI.4925-06.2007","volume":"27","author":"PV Zelenin","year":"2007","unstructured":"Zelenin, P.V., Orlovsky, G.N. & Deliagina, T.G. Sensory-motor transformation by individual command neurons. J. Neurosci. 27, 1024\u20131032 (2007).","journal-title":"J. Neurosci."},{"key":"BFnn2048_CR23","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0010-406X(64)90153-7","volume":"12","author":"CA Wiersma","year":"1964","unstructured":"Wiersma, C.A. & Ikeda, K. Interneurons commanding swimmeret movements in the crayfish, Procambarus clarkii (Girard). Comp. Biochem. Physiol. 12, 509\u2013525 (1964).","journal-title":"Comp. Biochem. Physiol."},{"key":"BFnn2048_CR24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev.ne.16.030193.001405","volume":"16","author":"KG Pearson","year":"1993","unstructured":"Pearson, K.G. Common principles of motor control in vertebrates and invertebrates. Annu. Rev. Neurosci. 16, 265\u2013297 (1993).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnn2048_CR25","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/80649","volume":"3","author":"MB Orger","year":"2000","unstructured":"Orger, M.B., Smear, M.C., Anstis, S.M. & Baier, H. Perception of fourier and non-fourier motion by larval zebrafish. Nat. Neurosci. 3, 1128\u20131133 (2000).","journal-title":"Nat. Neurosci."},{"key":"BFnn2048_CR26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000066699","volume":"60","author":"MA Borla","year":"2002","unstructured":"Borla, M.A., Palecek, B., Budick, S. & O'Malley, D.M. Prey capture by larval zebrafish: evidence for fine axial motor control. Brain Behav. Evol. 60, 207\u2013229 (2002).","journal-title":"Brain Behav. Evol."},{"key":"BFnn2048_CR27","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nature00931","volume":"418","author":"T Euler","year":"2002","unstructured":"Euler, T., Detwiler, P.B. & Denk, W. Directionally selective calcium signals in dendrites of starburst amacrine cells. Nature 418, 845\u2013852 (2002).","journal-title":"Nature"},{"key":"BFnn2048_CR28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2202-7-30","volume":"7","author":"SH Chung","year":"2006","unstructured":"Chung, S.H., Clark, D.A., Gabel, C.V., Mazur, E. & Samuel, A.D. The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation. BMC Neurosci. 7, 30 (2006).","journal-title":"BMC Neurosci."},{"key":"BFnn2048_CR29","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1021\/cr010379n","volume":"103","author":"A Vogel","year":"2003","unstructured":"Vogel, A. & Venugopalan, V. Mechanisms of pulsed laser ablation of biological tissues. Chem. Rev. 103, 577\u2013644 (2003).","journal-title":"Chem. Rev."},{"key":"BFnn2048_CR30","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1523\/JNEUROSCI.3036-04.2005","volume":"25","author":"A Leonardo","year":"2005","unstructured":"Leonardo, A. & Fee, M.S. Ensemble coding of vocal control in birdsong. J. Neurosci. 25, 652\u2013661 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn2048_CR31","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nn1010","volume":"6","author":"A d'Avella","year":"2003","unstructured":"d'Avella, A., Saltiel, P. & Bizzi, E. Combinations of muscle synergies in the construction of a natural motor behavior. Nat. Neurosci. 6, 300\u2013308 (2003).","journal-title":"Nat. Neurosci."},{"key":"BFnn2048_CR32","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1177\/107385802236969","volume":"8","author":"E Bizzi","year":"2002","unstructured":"Bizzi, E., d'Avella, A., Saltiel, P. & Tresch, M. Modular organization of spinal motor systems. Neuroscientist 8, 437\u2013442 (2002).","journal-title":"Neuroscientist"},{"key":"BFnn2048_CR33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0165-0270(01)00382-X","volume":"108","author":"E Gahtan","year":"2001","unstructured":"Gahtan, E. & O'Malley, D.M. Rapid lesioning of large numbers of identified vertebrate neurons: applications in zebrafish. J. Neurosci. Methods 108, 97\u2013110 (2001).","journal-title":"J. Neurosci. Methods"},{"key":"BFnn2048_CR34","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s003590050319","volume":"184","author":"SJ Zottoli","year":"1999","unstructured":"Zottoli, S.J., Newman, B.C., Rieff, H.I. & Winters, D.C. Decrease in occurrence of fast startle responses after selective Mauthner cell ablation in goldfish (Carassius auratus). J. Comp. Physiol. [A] 184, 207\u2013218 (1999).","journal-title":"J. Comp. Physiol. [A]"},{"key":"BFnn2048_CR35","doi-asserted-by":"publisher","first-page":"9294","DOI":"10.1523\/JNEUROSCI.2678-05.2005","volume":"25","author":"E Gahtan","year":"2005","unstructured":"Gahtan, E., Tanger, P. & Baier, H. Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum. J. Neurosci. 25, 9294\u20139303 (2005).","journal-title":"J. Neurosci."},{"key":"BFnn2048_CR36","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/cne.902510204","volume":"251","author":"B Mendelson","year":"1986","unstructured":"Mendelson, B. Development of reticulospinal neurons of the zebrafish. II. Early axonal outgrowth and cell body position. J. Comp. Neurol. 251, 172\u2013184 (1986).","journal-title":"J. Comp. Neurol."},{"key":"BFnn2048_CR37","doi-asserted-by":"publisher","first-page":"5684","DOI":"10.1523\/JNEUROSCI.4993-05.2006","volume":"26","author":"Y Kimura","year":"2006","unstructured":"Kimura, Y., Okamura, Y. & Higashijima, S. alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. J. Neurosci. 26, 5684\u20135697 (2006).","journal-title":"J. Neurosci."},{"key":"BFnn2048_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neuron.2006.11.011","volume":"53","author":"DH Bhatt","year":"2007","unstructured":"Bhatt, D.H., McLean, D.L., Hale, M.E. & Fetcho, J.R. Grading movement strength by changes in firing intensity versus recruitment of spinal interneurons. Neuron 53, 91\u2013102 (2007).","journal-title":"Neuron"},{"key":"BFnn2048_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nature05588","volume":"446","author":"DL McLean","year":"2007","unstructured":"McLean, D.L., Fan, J., Higashijima, S., Hale, M.E. & Fetcho, J.R. A topographic map of recruitment in spinal cord. Nature 446, 71\u201375 (2007).","journal-title":"Nature"},{"key":"BFnn2048_CR40","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1002\/dneu.20398","volume":"67","author":"M Chong","year":"2007","unstructured":"Chong, M. & Drapeau, P. Interaction between hindbrain and spinal networks during the development of locomotion in zebrafish. Dev. Neurobiol. 67, 933\u2013947 (2007).","journal-title":"Dev. Neurobiol."},{"key":"BFnn2048_CR41","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.neuron.2005.01.047","volume":"45","author":"CM Niell","year":"2005","unstructured":"Niell, C.M. & Smith, S.J. Functional imaging reveals rapid development of visual response properties in the zebrafish tectum. Neuron 45, 941\u2013951 (2005).","journal-title":"Neuron"},{"key":"BFnn2048_CR42","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.1523\/JNEUROSCI.0883-07.2007","volume":"27","author":"T Sato","year":"2007","unstructured":"Sato, T., Hamaoka, T., Aizawa, H., Hosoya, T. & Okamoto, H. Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish. J. Neurosci. 27, 5271\u20135279 (2007).","journal-title":"J. Neurosci."},{"key":"BFnn2048_CR43","doi-asserted-by":"publisher","first-page":"3986","DOI":"10.1152\/jn.00576.2003","volume":"90","author":"S Higashijima","year":"2003","unstructured":"Higashijima, S., Masino, M.A., Mandel, G. & Fetcho, J.R. Imaging neuronal activity during zebrafish behavior with a genetically encoded calcium indicator. J. Neurophysiol. 90, 3986\u20133997 (2003).","journal-title":"J. Neurophysiol."},{"key":"BFnn2048_CR44","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1242\/dev.126.17.3757","volume":"126","author":"JA Lister","year":"1999","unstructured":"Lister, J.A., Robertson, C.P., Lepage, T., Johnson, S.L. & Raible, D.W. nacre encodes a zebrafish microphthalmia-related protein that regulates neural crest\u2013derived pigment cell fate. Development 126, 3757\u20133767 (1999).","journal-title":"Development"},{"key":"BFnn2048_CR45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1126\/science.2321027","volume":"248","author":"W Denk","year":"1990","unstructured":"Denk, W., Strickler, J.H. & Webb, W.W. Two-photon laser scanning fluorescence microscopy. Science 248, 73\u201376 (1990).","journal-title":"Science"}],"container-title":["Nature Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nn2048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn2048","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nn2048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:01:41Z","timestamp":1684440101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nn2048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,10]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["BFnn2048"],"URL":"https:\/\/doi.org\/10.1038\/nn2048","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7896956.8252054","asserted-by":"object"}]},"ISSN":["1097-6256","1546-1726"],"issn-type":[{"value":"1097-6256","type":"print"},{"value":"1546-1726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,10]]}}}