{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:33:49Z","timestamp":1775241229068,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1038\/s41366-025-01816-3","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T09:32:20Z","timestamp":1748943140000},"page":"1763-1769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between adiposity distribution and high-sensitivity C-reactive protein, adipokines, interleukins and plasminogen activator inhibitor-1"],"prefix":"10.1038","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-0283","authenticated-orcid":false,"given":"Vanda","family":"Craveiro","sequence":"first","affiliation":[]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[]},{"given":"Elisabete","family":"Ramos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"1816_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41574-021-00471-8","volume":"17","author":"P Morigny","year":"2021","unstructured":"Morigny P, Boucher J, Arner P, Langin D. Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nat Rev Endocrinol. 2021;17:276\u201395. https:\/\/doi.org\/10.1038\/s41574-021-00471-8.","journal-title":"Nat Rev Endocrinol"},{"key":"1816_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/oby.2003.3","volume":"11","author":"W Shen","year":"2003","unstructured":"Shen W, Wang Z, Punyanita M, Lei J, Sinav A, Kral JG, et al. Adipose tissue quantification by imaging methods: a proposed classification. Obes Res. 2003;11:5\u201316. https:\/\/doi.org\/10.1038\/oby.2003.3.","journal-title":"Obes Res"},{"key":"1816_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67177-1","volume":"10","author":"M Lenz","year":"2020","unstructured":"Lenz M, Arts ICW, Peeters RLM, de Kok TM, Ertaylan G. Adipose tissue in health and disease through the lens of its building blocks. Sci Rep. 2020;10:10433. https:\/\/doi.org\/10.1038\/s41598-020-67177-1.","journal-title":"Sci Rep"},{"key":"1816_CR4","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nri1937","volume":"6","author":"H Tilg","year":"2006","unstructured":"Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6:772\u201383. https:\/\/doi.org\/10.1038\/nri1937.","journal-title":"Nat Rev Immunol"},{"key":"1816_CR5","doi-asserted-by":"publisher","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","volume":"320","author":"T Kawai","year":"2021","unstructured":"Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320:C375\u2013C91. https:\/\/doi.org\/10.1152\/ajpcell.00379.2020.","journal-title":"Am J Physiol Cell Physiol"},{"key":"1816_CR6","doi-asserted-by":"publisher","unstructured":"Hildebrandt X, Ibrahim M, Peltzer N Cell death and inflammation during obesity: \u201cknow my methods, WAT(son). Cell Death Differ. 2022. https:\/\/doi.org\/10.1038\/s41418-022-01062-4.","DOI":"10.1038\/s41418-022-01062-4"},{"key":"1816_CR7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1161\/01.cir.0000053731.05365.5a","volume":"107","author":"ET Yeh","year":"2003","unstructured":"Yeh ET, Willerson JT. Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation. 2003;107:370\u20131. https:\/\/doi.org\/10.1161\/01.cir.0000053731.05365.5a.","journal-title":"Circulation"},{"key":"1816_CR8","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.ejrad.2016.04.004","volume":"85","author":"A Bazzocchi","year":"2016","unstructured":"Bazzocchi A, Ponti F, Albisinni U, Battista G, Guglielmi G. DXA: technical aspects and application. Eur J Radio. 2016;85:1481\u201392. https:\/\/doi.org\/10.1016\/j.ejrad.2016.04.004.","journal-title":"Eur J Radio"},{"key":"1816_CR9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","volume":"58","author":"R Tibshirani","year":"1996","unstructured":"Tibshirani R. Regression shrinkage and selection via the lasso. J R Stat Soc Ser B. 1996;58:267\u201388.","journal-title":"J R Stat Soc Ser B"},{"key":"1816_CR10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ecl.2020.02.008","volume":"49","author":"KM Gavin","year":"2020","unstructured":"Gavin KM, Bessesen DH. Sex differences in adipose tissue function. Endocrinol Metab Clin North Am. 2020;49:215\u201328. https:\/\/doi.org\/10.1016\/j.ecl.2020.02.008.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"1816_CR11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.ahj.2006.02.015","volume":"152","author":"SG Lakoski","year":"2006","unstructured":"Lakoski SG, Cushman M, Criqui M, Rundek T, Blumenthal RS, D\u2019Agostino RB Jr., et al. Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort. Am Heart J. 2006;152:593\u20138. https:\/\/doi.org\/10.1016\/j.ahj.2006.02.015.","journal-title":"Am Heart J"},{"key":"1816_CR12","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1590\/s0100-879x2008000500003","volume":"41","author":"A Nazmi","year":"2008","unstructured":"Nazmi A, Oliveira IO, Victora CG. Correlates of C-reactive protein levels in young adults: a population-based cohort study of 3827 subjects in Brazil. Braz J Med Biol Res. 2008;41:357\u201367. https:\/\/doi.org\/10.1590\/s0100-879x2008000500003.","journal-title":"Braz J Med Biol Res"},{"key":"1816_CR13","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1538-7836.2007.02851.x","volume":"6","author":"A Arcari","year":"2008","unstructured":"Arcari A, Zito F, Di Castelnuovo A, De Curtis A, Dirckx C, Arnout J, et al. C reactive protein and its determinants in healthy men and women from European regions at different risk of coronary disease: the IMMIDIET Project. J Thromb Haemost. 2008;6:436\u201343. https:\/\/doi.org\/10.1111\/j.1538-7836.2007.02851.x.","journal-title":"J Thromb Haemost"},{"key":"1816_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-7075-3-18","volume":"3","author":"J Smith","year":"2006","unstructured":"Smith J, Al-Amri M, Sniderman A, Cianflone K. Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB\/apoA1 ratio in Asian Indian and Caucasian men and women. Nutr Metab. 2006;3:18. https:\/\/doi.org\/10.1186\/1743-7075-3-18.","journal-title":"Nutr Metab"},{"key":"1816_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1538-7836.2007.02311.x","volume":"5","author":"FW Asselbergs","year":"2007","unstructured":"Asselbergs FW, Williams SM, Hebert PR, Coffey CS, Hillege HL, Navis G, et al. Gender-specific correlations of plasminogen activator inhibitor-1 and tissue plasminogen activator levels with cardiovascular disease-related traits. J Thromb Haemost. 2007;5:313\u201320. https:\/\/doi.org\/10.1111\/j.1538-7836.2007.02311.x.","journal-title":"J Thromb Haemost"},{"key":"1816_CR16","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/ijo.2009.286","volume":"34","author":"KN Manolopoulos","year":"2010","unstructured":"Manolopoulos KN, Karpe F, Frayn KN. Gluteofemoral body fat as a determinant of metabolic health. Int J Obes. 2010;34:949\u201359. https:\/\/doi.org\/10.1038\/ijo.2009.286.","journal-title":"Int J Obes"},{"key":"1816_CR17","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/sj.ijo.0800585","volume":"22","author":"B Janand-Delenne","year":"1998","unstructured":"Janand-Delenne B, Chagnaud C, Raccah D, Alessi MC, Juhan-Vague I, Vague P. Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in women. Int J Obes Relat Metab Disord. 1998;22:312\u20137. https:\/\/doi.org\/10.1038\/sj.ijo.0800585.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"1816_CR18","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3389\/fphys.2019.01486","volume":"10","author":"AM Nauli","year":"2019","unstructured":"Nauli AM, Matin S. Why do men accumulate abdominal visceral fat?. Front Physiol. 2019;10:1486. https:\/\/doi.org\/10.3389\/fphys.2019.01486.","journal-title":"Front Physiol"},{"key":"1816_CR19","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/s44222-023-00030-y","volume":"1","author":"J Deckers","year":"2023","unstructured":"Deckers J, Anbergen T, Hokke AM, de Dreu A, Schrijver DP, de Bruin K, et al. Engineering cytokine therapeutics. Nat Rev Bioeng. 2023;1:286\u2013303. https:\/\/doi.org\/10.1038\/s44222-023-00030-y.","journal-title":"Nat Rev Bioeng"},{"key":"1816_CR20","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","volume":"9","author":"NR Sproston","year":"2018","unstructured":"Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9:754. https:\/\/doi.org\/10.3389\/fimmu.2018.00754.","journal-title":"Front Immunol"},{"key":"1816_CR21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/jcp.22783","volume":"227","author":"AK Ghosh","year":"2012","unstructured":"Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol. 2012;227:493\u2013507. https:\/\/doi.org\/10.1002\/jcp.22783.","journal-title":"J Cell Physiol"},{"key":"1816_CR22","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s40618-019-01052-3","volume":"42","author":"I Barchetta","year":"2019","unstructured":"Barchetta I, Cimini FA, Ciccarelli G, Baroni MG, Cavallo MG. Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation. J Endocrinol Invest. 2019;42:1257\u201372. https:\/\/doi.org\/10.1007\/s40618-019-01052-3.","journal-title":"J Endocrinol Invest"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41366-025-01816-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41366-025-01816-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41366-025-01816-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:24:42Z","timestamp":1758788682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41366-025-01816-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1816"],"URL":"https:\/\/doi.org\/10.1038\/s41366-025-01816-3","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"29 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}