{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:13:10Z","timestamp":1767211990113,"version":"3.37.3"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire ; French Research Ministry"},{"name":"Canc\u00e9ropole Grand Ouest ; R\u00e9gion Bretagne ; Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019H\u00e9matologie"},{"DOI":"10.13039\/501100004099","name":"Ligue R\u00e9gionale contre le cancer ;","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1038\/s41375-021-01409-9","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T19:02:35Z","timestamp":1631905355000},"page":"549-554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell\u00a0acute lymphoblastic leukemia leukemogenesis"],"prefix":"10.1038","volume":"36","author":[{"given":"H\u00e9l\u00e8ne","family":"Jakobczyk","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-0642","authenticated-orcid":false,"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3718-3210","authenticated-orcid":false,"given":"Lydie","family":"Debaize","sequence":"additional","affiliation":[]},{"given":"Benoit","family":"Soubise","sequence":"additional","affiliation":[]},{"given":"St\u00e9phane","family":"Avner","sequence":"additional","affiliation":[]},{"given":"Aur\u00e9lien A.","family":"S\u00e9randour","sequence":"additional","affiliation":[]},{"given":"J\u00e9r\u00e9mie","family":"Rouger-Gaudichon","sequence":"additional","affiliation":[]},{"given":"Anne-Ga\u00eblle","family":"Rio","sequence":"additional","affiliation":[]},{"given":"Jason S.","family":"Carroll","sequence":"additional","affiliation":[]},{"given":"Hana","family":"Raslova","sequence":"additional","affiliation":[]},{"given":"David","family":"Gilot","sequence":"additional","affiliation":[]},{"given":"Ziling","family":"Liu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-614X","authenticated-orcid":false,"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-4140","authenticated-orcid":false,"given":"Gilles","family":"Salbert","sequence":"additional","affiliation":[]},{"given":"Nathalie","family":"Douet-Guilbert","sequence":"additional","affiliation":[]},{"given":"Laurent","family":"Corcos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-742X","authenticated-orcid":false,"given":"Marie-Dominique","family":"Galibert","sequence":"additional","affiliation":[]},{"given":"Virginie","family":"Gandemer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-9670","authenticated-orcid":false,"given":"Marie-B\u00e9reng\u00e8re","family":"Troadec","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"1409_CR1","doi-asserted-by":"crossref","unstructured":"Greaves M. A causal mechanism for childhood acute lymphoblastic leukaemia. Nat Rev Cancer. 2018;18:471.","DOI":"10.1038\/s41568-018-0015-6"},{"key":"1409_CR2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/ng.2874","volume":"46","author":"E Papaemmanuil","year":"2014","unstructured":"Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J. et al. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet. 2014;46:116\u201325.","journal-title":"Nat Genet"},{"key":"1409_CR3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/sj.leu.2403182","volume":"18","author":"S H\u00fcbner","year":"2003","unstructured":"H\u00fcbner S, Cazzaniga G, Flohr T, van der Velden VHJ, Konrad M, P\u00f6tschger U, et al. High incidence and unique features of antigen receptor gene rearrangements in TEL\u2013AML1-positive leukemias. Leukemia 2003;18:84\u201391.","journal-title":"Leukemia"},{"key":"1409_CR4","doi-asserted-by":"publisher","first-page":"e1002533","DOI":"10.1371\/journal.pgen.1002533","volume":"8","author":"E Waanders","year":"2012","unstructured":"Waanders E, Scheijen B, van der Meer LT, van Reijmersdal SV, van Emst L, Kroeze Y, et al. The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution. PLoS Genet. 2012;8:e1002533.","journal-title":"PLoS Genet"},{"key":"1409_CR5","doi-asserted-by":"publisher","first-page":"6717","DOI":"10.1074\/jbc.M710301200","volume":"283","author":"M Zhang","year":"2008","unstructured":"Zhang M, Swanson PC. V(D)J Recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies. J Biol Chem. 2008;283:6717\u201327.","journal-title":"J Biol Chem"},{"key":"1409_CR6","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1182\/blood-2003-01-0338","volume":"102","author":"ME Ross","year":"2003","unstructured":"Ross ME, Zhou X, Song G, Shurtleff SA, Girtman K, Williams WK, et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003;102:2951\u20139.","journal-title":"Blood"},{"key":"1409_CR7","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/ni.3160","volume":"16","author":"S Swaminathan","year":"2015","unstructured":"Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon S-M. et al. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015;16:766\u201374.","journal-title":"Nat Immunol"},{"key":"1409_CR8","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1158\/0008-5472.CAN-17-0701","volume":"77","author":"G Rodr\u00edguez-Hern\u00e1ndez","year":"2017","unstructured":"Rodr\u00edguez-Hern\u00e1ndez G, Hauer J, Mart\u00edn-Lorenzo A, Sch\u00e4fer D, Bartenhagen C, Garc\u00eda-Ram\u00edrez I, et al. Infection exposure promotes ETV6-RUNX1 precursor B-cell leukemia via impaired H3K4 demethylases. Cancer Res. 2017;77:4365\u201377.","journal-title":"Cancer Res"},{"key":"1409_CR9","doi-asserted-by":"publisher","first-page":"11214","DOI":"10.1093\/nar\/gky756","volume":"46","author":"L Debaize","year":"2018","unstructured":"Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio A-G, S\u00e9randour AA, et al. Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Nucleic Acids Res. 2018;46:11214\u201328.","journal-title":"Nucleic Acids Res"},{"key":"1409_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13045-021-01051-z","volume":"14","author":"H Jakobczyk","year":"2021","unstructured":"Jakobczyk H, Debaize L, Soubise B, Avner S, Rouger-Gaudichon J, Commet S. et al. Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia. J Hematol OncolJ Hematol Oncol. 2021;14:47","journal-title":"J Hematol OncolJ Hematol Oncol"},{"key":"1409_CR11","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nature14136","volume":"517","author":"S Konermann","year":"2015","unstructured":"Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C. et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature. 2015;517:583\u20138.","journal-title":"Nature"},{"key":"1409_CR12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41467-020-14362-5","volume":"11","author":"K Li","year":"2020","unstructured":"Li K, Liu Y, Cao H, Zhang Y, Gu Z, Liu X. et al. Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing. Nat Commun. 2020;11:485","journal-title":"Nat Commun"},{"key":"1409_CR13","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1128\/MCB.16.4.1349","volume":"16","author":"SW Hiebert","year":"1996","unstructured":"Hiebert SW, Sun W, Davis JN, Golub T, Shurtleff S, Buijs A. et al. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol. 1996;16:1349\u201355.","journal-title":"Mol Cell Biol"},{"key":"1409_CR14","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1073\/pnas.94.5.1949","volume":"94","author":"S Fears","year":"1997","unstructured":"Fears S, Gavin M, Zhang DE, Hetherington C, Ben-David Y, Rowley JD. et al. Functional characterization of ETV6 and ETV6\/CBFA2 in the regulation of the MCSFR proximal promoter. Proc Natl Acad Sci USA. 1997;94:1949\u201354.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1409_CR15","doi-asserted-by":"crossref","unstructured":"Trancoso I, Bonnet M, Gardner R, Carneiro J, Barreto VM, Demengeot J, et al. A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity. Front Immunol [Internet]. 16 mai 2013 [cit\u00e9 4 avr 2019];4. Disponible sur: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3655321\/.","DOI":"10.3389\/fimmu.2013.00110"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41375-021-01409-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-021-01409-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41375-021-01409-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T09:09:19Z","timestamp":1643706559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41375-021-01409-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1409"],"URL":"https:\/\/doi.org\/10.1038\/s41375-021-01409-9","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"type":"print","value":"0887-6924"},{"type":"electronic","value":"1476-5551"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"assertion":[{"value":"4 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}