{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:27:53Z","timestamp":1773689273969,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1038\/s41380-017-0011-3","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T17:59:42Z","timestamp":1518199182000},"page":"1489-1501","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model"],"prefix":"10.1038","volume":"24","author":[{"given":"Hong","family":"Pan","sequence":"first","affiliation":[]},{"given":"B\u00e1rbara","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Gesine","family":"Saher","sequence":"additional","affiliation":[]},{"given":"Ekrem","family":"Dere","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Tapken","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Mitjans","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Seidel","sequence":"additional","affiliation":[]},{"given":"Janina","family":"Wesolowski","sequence":"additional","affiliation":[]},{"given":"Debia","family":"Wakhloo","sequence":"additional","affiliation":[]},{"given":"Christina","family":"Klein-Schmidt","sequence":"additional","affiliation":[]},{"given":"Anja","family":"Ronnenberg","sequence":"additional","affiliation":[]},{"given":"Kerstin","family":"Schwabe","sequence":"additional","affiliation":[]},{"given":"Ralf","family":"Trippe","sequence":"additional","affiliation":[]},{"given":"Kerstin","family":"M\u00e4tz-Rensing","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Berghoff","sequence":"additional","affiliation":[]},{"given":"Yazeed","family":"Al-Krinawe","sequence":"additional","affiliation":[]},{"given":"Henrik","family":"Martens","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Begemann","sequence":"additional","affiliation":[]},{"given":"Winfried","family":"St\u00f6cker","sequence":"additional","affiliation":[]},{"given":"Franz-Josef","family":"Kaup","sequence":"additional","affiliation":[]},{"given":"Reinhard","family":"Mischke","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-7423","authenticated-orcid":false,"given":"Susann","family":"Boretius","sequence":"additional","affiliation":[]},{"given":"Klaus-Armin","family":"Nave","sequence":"additional","affiliation":[]},{"given":"Joachim K.","family":"Krauss","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-7787","authenticated-orcid":false,"given":"Michael","family":"Hollmann","sequence":"additional","affiliation":[]},{"given":"Fred","family":"L\u00fchder","sequence":"additional","affiliation":[]},{"given":"Hannelore","family":"Ehrenreich","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"11_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ana.21050","volume":"61","author":"J Dalmau","year":"2007","unstructured":"Dalmau J, Tuzun E, Wu HY, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61:25\u201336.","journal-title":"Ann Neurol"},{"key":"11_CR2","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S1474-4422(08)70224-2","volume":"7","author":"J Dalmau","year":"2008","unstructured":"Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008;7:1091\u20138.","journal-title":"Lancet Neurol"},{"key":"11_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S1474-4422(10)70253-2","volume":"10","author":"J Dalmau","year":"2011","unstructured":"Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10:63\u201374.","journal-title":"Lancet Neurol"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1474-4422(12)70310-1","volume":"12","author":"MJ Titulaer","year":"2013","unstructured":"Titulaer MJ, McCracken L, Gabilondo I, Armangue T, Glaser C, Iizuka T, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013;12:157\u201365.","journal-title":"Lancet Neurol"},{"key":"11_CR5","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1038\/mp.2013.110","volume":"19","author":"C Hammer","year":"2014","unstructured":"Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, et al. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry. 2014;19:1143\u20139.","journal-title":"Mol Psychiatry"},{"key":"11_CR6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ana.24189","volume":"76","author":"L Dahm","year":"2014","unstructured":"Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, et al. Seroprevalence of autoantibodies against brain antigens in health and disease. Ann Neurol. 2014;76:82\u201394.","journal-title":"Ann Neurol"},{"key":"11_CR7","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1001\/jamapsychiatry.2014.469","volume":"71","author":"J Steiner","year":"2014","unstructured":"Steiner J, Teegen B, Schiltz K, Bernstein HG, Stoecker W, Bogerts B. Prevalence of N-methyl-D-aspartate receptor autoantibodies in the peripheral blood: healthy control samples revisited. JAMA Psychiatry. 2014;71:838\u20139.","journal-title":"JAMA Psychiatry"},{"key":"11_CR8","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/STROKEAHA.114.008323","volume":"46","author":"M Zerche","year":"2015","unstructured":"Zerche M, Weissenborn K, Ott C, Dere E, Asif AR, Worthmann H, et al. Preexisting serum autoantibodies against the NMDAR subunit NR1 modulate evolution of lesion size in acute ischemic stroke. Stroke. 2015;46:1180\u20136.","journal-title":"Stroke"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/ana.24545","volume":"79","author":"E Castillo-Gomez","year":"2016","unstructured":"Castillo-Gomez E, Kastner A, Steiner J, Schneider A, Hettling B, Poggi G, et al. The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1. Ann Neurol. 2016;79:144\u201351.","journal-title":"Ann Neurol"},{"issue":"12","key":"11_CR10","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1038\/mp.2016.125","volume":"22","author":"E Castillo-G\u00f3mez","year":"2016","unstructured":"Castillo-Gomez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H et al. All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry. 2016;22:1776\u2013178.","journal-title":"Molecular Psychiatry"},{"key":"11_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/imr.12419","volume":"271","author":"J Abramson","year":"2016","unstructured":"Abramson J, Husebye ES. Autoimmune regulator and self-tolerance\u2014molecular and clinical aspects. Immunol Rev. 2016;271:127\u201340.","journal-title":"Immunol Rev"},{"key":"11_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0167-5699(91)90093-9","volume":"12","author":"I Cohen","year":"1991","unstructured":"Cohen I, Young D. Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today. 1991;12:105\u201310.","journal-title":"Immunol Today"},{"key":"11_CR13","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/0952-7915(95)80053-0","volume":"7","author":"A Coutinho","year":"1995","unstructured":"Coutinho A, Kazatchkine MD, Avrameas S. Natural autoantibodies. Curr Opin Immunol. 1995;7:812\u20138.","journal-title":"Curr Opin Immunol"},{"key":"11_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3389\/fimmu.2017.00181","volume":"8","author":"H Ehrenreich","year":"2017","unstructured":"Ehrenreich H. Autoantibodies against the N-methyl-d-aspartate receptor subunit NR1: untangling apparent inconsistencies for clinical practice. Front Immunol. 2017;8:181.","journal-title":"Front Immunol"},{"key":"11_CR15","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fimmu.2016.00198","volume":"7","author":"PI Lobo","year":"2016","unstructured":"Lobo PI. Role of natural autoantibodies and natural IgM anti-leucocyte autoantibodies in health and disease. Front Immunol. 2016;7:198.","journal-title":"Front Immunol"},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3389\/fimmu.2017.01101","volume":"8","author":"S Mader","year":"2017","unstructured":"Mader S, Brimberg L, Diamond B. The role of brain-reactive autoantibodies in brain pathology and cognitive impairment. Front Immunol. 2017;8:1101.","journal-title":"Front Immunol"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1615\/CritRevImmunol.2016018175","volume":"36","author":"TT Nguyen","year":"2016","unstructured":"Nguyen TT, Baumgarth N. Natural IgM and the development of b cell-mediated autoimmune diseases. Crit Rev Immunol. 2016;36:163\u201377.","journal-title":"Crit Rev Immunol"},{"key":"11_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.biopsych.2013.07.040","volume":"75","author":"E Coutinho","year":"2014","unstructured":"Coutinho E, Harrison P, Vincent A. Do neuronal autoantibodies cause psychosis? A neuroimmunological perspective. Biol Psychiatry. 2014;75:269\u201375.","journal-title":"Biol Psychiatry"},{"key":"11_CR19","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/nri2529","volume":"9","author":"B Diamond","year":"2009","unstructured":"Diamond B, Huerta P, Mina-Osorio P, Kowal C, Volpe B. Losing your nerves? Maybe it\u2019s the antibodies. Nat Rev Immunol. 2009;9:449\u201356.","journal-title":"Nat Rev Immunol"},{"key":"11_CR20","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/mp.2014.52","volume":"19","author":"C Hammer","year":"2014","unstructured":"Hammer C, Zerche M, Schneider A, Begemann M, Nave KA, Ehrenreich H. Apolipoprotein E4 carrier status plus circulating anti-NMDAR1 autoantibodies: association with schizoaffective disorder. Mol Psychiatry. 2014;19:1054\u20136.","journal-title":"Mol Psychiatry"},{"key":"11_CR21","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1093\/brain\/aww208","volume":"139","author":"J Kreye","year":"2016","unstructured":"Kreye J, Wenke NK, Chayka M, Leubner J, Murugan R, Maier N, et al. Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain. 2016;139:2641\u201352.","journal-title":"Brain"},{"key":"11_CR22","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/archgenpsychiatry.2010.107","volume":"67","author":"MGS Begemann","year":"2010","unstructured":"Begemann MGS, Papiol S, Malzahn D, Krampe H, Ribbe K, et al. Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms. Arch Gen Psychiatry. 2010;67:879\u201388.","journal-title":"Arch Gen Psychiatry"},{"key":"11_CR23","doi-asserted-by":"publisher","first-page":"0","DOI":"10.1186\/1471-244X-10-91","volume":"10","author":"K Ribbe.","year":"2010","unstructured":"Ribbe. K, Friedrichs H, Begemann M, Grube S, Papiol S, K\u00e4stner. A, et al. The cross-sectional GRAS sample: a comprehensive phenotypical data collection of schizophrenic patients. BMC Psychiatry. 2010;10:0\u201320.","journal-title":"BMC Psychiatry"},{"key":"11_CR24","unstructured":"American Psychiatric Association. (2000) Diagnostic and statistical manual of mental disorders. 4th edn American Psychiatric Press, Washington, DC. ."},{"key":"11_CR25","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jneuroim.2010.09.012","volume":"231","author":"KP Wandinger","year":"2011","unstructured":"Wandinger KP, Saschenbrecker S, Stoecker W, Dalmau J. Anti-NMDA-receptor encephalitis: a severe, multistage, treafa disorder presenting with psychosis. J Neuroimmunol. 2011;231:86\u201391.","journal-title":"J Neuroimmunol"},{"key":"11_CR26","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nbt0787-697","volume":"5","author":"MDP Boyle","year":"1987","unstructured":"Boyle MDP, Reis KJ. Bacterial Fc receptors. Nat Biotechnol. 1987;5:697\u2013703.","journal-title":"Nat Biotechnol"},{"key":"11_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep12805","volume":"5","author":"H Pruss","year":"2015","unstructured":"Pruss H, Leubner J, Wenke NK, Czirjak GA, Szentiks CA, Greenwood AD. Anti-NMDA receptor encephalitis in the polar bear (Ursus maritimus) Knut. Sci Rep. 2015;5:1\u20137.","journal-title":"Sci Rep"},{"key":"11_CR28","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1126\/science.1179220","volume":"190","author":"KBD Toyka","year":"1975","unstructured":"Toyka KBD, Pestronk A, Kao I. Myasthenia gravis: passive transfer from man to mouse. Science. 1975;190:397\u20139.","journal-title":"Science"},{"key":"11_CR29","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676\u201382.","journal-title":"Nat Methods"},{"key":"11_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms14241","volume":"8","author":"SA Berghoff","year":"2017","unstructured":"Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, et al. Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nat Commun. 2017;8:1\u201315.","journal-title":"Nat Commun"},{"key":"11_CR31","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s40478-017-0497-6","volume":"5","author":"SA Berghoff","year":"2017","unstructured":"Berghoff SA, D\u00fcking T, Spieth L, Winchenbach J, Stumpf SK, Gerndt N, et al. Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model. Acta Neuropathol Commun. 2017;5:94.","journal-title":"Acta Neuropathol Commun."},{"key":"11_CR32","doi-asserted-by":"publisher","first-page":"8434","DOI":"10.4049\/jimmunol.180.12.8434","volume":"180","author":"S Wust","year":"2008","unstructured":"Wust S, van den Brandt J, Tischner D, Kleiman A, Tuckermann JP, Gold R, et al. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol. 2008;180:8434\u201343.","journal-title":"J Immunol"},{"key":"11_CR33","first-page":"181","volume":"8","author":"E Dere","year":"2014","unstructured":"Dere E, Dahm L, Lu D, Hammerschmidt K, Ju A, Tantra M, et al. Heterozygous ambra1 deficiency in mice: a genetic trait with autism-like behavior restricted to the female gender. Front Behav Neurosci. 2014;8:181.","journal-title":"Front Behav Neurosci"},{"key":"11_CR34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.bbr.2014.04.021","volume":"277","author":"E Dere","year":"2015","unstructured":"Dere E, Winkler D, Ritter C, Ronnenberg A, Poggi G, Patzig J, et al. Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A\/C receptor agonist. Behav Brain Res. 2015;277:254\u201363.","journal-title":"Behav Brain Res"},{"key":"11_CR35","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s12311-015-0645-0","volume":"14","author":"PR Netrakanti","year":"2015","unstructured":"Netrakanti PR, Cooper BH, Dere E, Poggi G, Winkler D, Brose N, et al. Fast cerebellar reflex circuitry requires synaptic vesicle priming by munc13-3. Cerebellum. 2015;14:264\u201383.","journal-title":"Cerebellum"},{"key":"11_CR36","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbr.2017.02.011","volume":"352","author":"Daniela Winkler","year":"2018","unstructured":"Winkler D, Daher F, Wustefeld L, Hammerschmidt K, Poggi G, Seelbach A et al. Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93. Behav Brain Res. 2017. https:\/\/doi.org\/10.1016\/j.bbr.2017.02.011 (e-pub ahead of print).","journal-title":"Behavioural Brain Research"},{"key":"11_CR37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1601-183X.2010.00590.x","volume":"9","author":"K Radyushkin","year":"2010","unstructured":"Radyushkin K, El-Kordi A, Boretius S, Castaneda S, Ronnenberg A, Reim K, et al. Complexin2 null mutation requires a \u2018second hit\u2019 for induction of phenotypic changes relevant to schizophrenia. Genes Brain Behav. 2010;9:592\u2013602.","journal-title":"Genes Brain Behav"},{"key":"11_CR38","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1001\/jamapsychiatry.2014.35","volume":"71","author":"C Akdeniz","year":"2014","unstructured":"Akdeniz C, Tost H, Streit F, Haddad L, Wust S, Schafer A, et al. Neuroimaging evidence for a role of neural social stress processing in ethnic minority-associated environmental risk. JAMA Psychiatry. 2014;71:672\u201380.","journal-title":"JAMA Psychiatry"},{"key":"11_CR39","doi-asserted-by":"publisher","first-page":"e2225","DOI":"10.7717\/peerj.2225","volume":"4","author":"SL Jacobson","year":"2016","unstructured":"Jacobson SL, Ross SR, Bloomsmith MA. Characterizing abnormal behavior in a large population of zoo-housed chimpanzees: prevalence and potential influencing factors. PeerJ. 2016;4:e2225.","journal-title":"PeerJ"},{"key":"11_CR40","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/S2215-0366(14)70379-7","volume":"1","author":"B Stepniak","year":"2014","unstructured":"Stepniak B, Papiol S, Hammer C, Ramin A, Everts S, Hennig L, et al. Accumulated environmental risk determining age at schizophrenia onset: a deep phenotyping-based study. Lancet Psychiatry. 2014;1:444\u201353.","journal-title":"Lancet Psychiatry"},{"key":"11_CR41","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0306-4530(97)00042-5","volume":"2","author":"M Maes","year":"1997","unstructured":"Maes M, Hendriks D, Gastel AV, Demedts P, Wauters A, Neels H, et al. Effects of psychological stress on serum immunoglobulin, complement and acute phase protein concentrationsin normal volunteers. Psychoneuroendocrinology. 1997;2:397\u2013409.","journal-title":"Psychoneuroendocrinology"},{"key":"11_CR42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1371\/journal.pone.0060726","volume":"8","author":"EP Nagele","year":"2013","unstructured":"Nagele EP, Han M, Acharya NK, DeMarshall C, Kosciuk MC, Nagele RG. Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease. PLoS ONE. 2013;8:4.","journal-title":"PLoS ONE"},{"key":"11_CR43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/brain\/awu310","volume":"138","author":"J Planaguma","year":"2015","unstructured":"Planaguma J, Leypoldt F, Mannara F, Gutierrez-Cuesta J, Martin-Garcia E, Aguilar E, et al. Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice. Brain. 2015;138:94\u2013109.","journal-title":"Brain"},{"key":"11_CR44","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neures.2014.06.002","volume":"85","author":"S Busse","year":"2014","unstructured":"Busse S, Brix B, Kunschmann R, Bogerts B, Stoecker W, Busse M. N-methyl-d-aspartate glutamate receptor (NMDA-R) antibodies in mild cognitive impairment and dementias. Neurosci Res. 2014;85:58\u201364.","journal-title":"Neurosci Res"},{"key":"11_CR45","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/acn3.120","volume":"1","author":"S Doss","year":"2014","unstructured":"Doss S, Wandinger KP, Hyman BT, Panzer JA, Synofzik M, Dickerson B, et al. High prevalence of NMDA receptor IgA\/IgM antibodies in different dementia types. Ann Clin Transl Neurol. 2014;1:822\u201332.","journal-title":"Ann Clin Transl Neurol"},{"key":"11_CR46","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00401-009-0582-4","volume":"118","author":"E Tuzun","year":"2009","unstructured":"Tuzun E, Zhou L, Baehring JM, Bannykh S, Rosenfeld MR, Dalmau J. Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol. 2009;118:737\u201343.","journal-title":"Acta Neuropathol"},{"key":"11_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ejphar.2016.05.009","volume":"784","author":"J Du","year":"2016","unstructured":"Du J, Li XH, Li YJ. Glutamate in peripheral organs: biology and pharmacology. Eur J Pharmacol. 2016;784:42\u20138.","journal-title":"Eur J Pharmacol"},{"key":"11_CR48","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.drudis.2016.01.016","volume":"21","author":"DM Gerhard","year":"2016","unstructured":"Gerhard DM, Wohleb ES, Duman RS. Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity. Drug Discov Today. 2016;21:454\u201364.","journal-title":"Drug Discov Today"},{"key":"11_CR49","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1002\/da.22501","volume":"33","author":"CG Abdallah","year":"2016","unstructured":"Abdallah CG, Adams TG, Kelmendi B, Esterlis I, Sanacora G, Krystal JH. Ketamine\u2019s mechanism of action: a path to rapid-acting antidepressants. Depress Anxiety. 2016;33:689\u201397.","journal-title":"Depress Anxiety"},{"key":"11_CR50","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.bbi.2009.04.001","volume":"23","author":"JK Alexander","year":"2009","unstructured":"Alexander JK, DeVries AC, Kigerl KA, Dahlman JM, Popovich PG. Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation. Brain Behav Immun. 2009;23:851\u201360.","journal-title":"Brain Behav Immun"},{"key":"11_CR51","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1515\/revneuro-2015-0066","volume":"27","author":"A Rubio-Casillas","year":"2016","unstructured":"Rubio-Casillas A, Fernandez-Guasti A. The dose makes the poison: from glutamate-mediated neurogenesis to neuronal atrophy and depression. Rev Neurosci. 2016;27:599\u2013622.","journal-title":"Rev Neurosci"},{"key":"11_CR52","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.bbi.2007.01.005","volume":"21","author":"A Nair","year":"2007","unstructured":"Nair A, Hunzeker J, Bonneau RH. Modulation of microglia and CD8(+) T cell activation during the development of stress-induced herpes simplex virus type-1 encephalitis. Brain Behav Immun. 2007;21:791\u2013806.","journal-title":"Brain Behav Immun"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41380-017-0011-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-017-0011-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41380-017-0011-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T03:08:23Z","timestamp":1719803303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41380-017-0011-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["11"],"URL":"https:\/\/doi.org\/10.1038\/s41380-017-0011-3","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]},"assertion":[{"value":"29 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"WS is a member of the board and holds stocks in Euroimmun AG. HM is a full-time employee of Synaptic Systems GmbH. The remaining authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}