{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:37:48Z","timestamp":1767152268838,"version":"build-2238731810"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/s41397-018-0057-x","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T11:18:02Z","timestamp":1538565482000},"page":"83-96","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients"],"prefix":"10.1038","volume":"19","author":[{"given":"Luz M.","family":"Canet","sequence":"first","affiliation":[]},{"given":"Jose M.","family":"S\u00e1nchez-Maldonado","sequence":"additional","affiliation":[]},{"given":"Rafael","family":"C\u00e1liz","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Rodr\u00edguez-Ramos","sequence":"additional","affiliation":[]},{"given":"Carmen B.","family":"Lupia\u00f1ez","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Canh\u00e3o","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Mart\u00ednez-Bueno","sequence":"additional","affiliation":[]},{"given":"Alejandro","family":"Escudero","sequence":"additional","affiliation":[]},{"given":"Juana","family":"Segura-Catena","sequence":"additional","affiliation":[]},{"given":"Signe B","family":"Sorensen","sequence":"additional","affiliation":[]},{"given":"Merete L","family":"Hetland","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda Jos\u00e9","family":"Soto-Pino","sequence":"additional","affiliation":[]},{"given":"Miguel A.","family":"Ferrer","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Garc\u00eda","sequence":"additional","affiliation":[]},{"given":"Bente","family":"Glintborg","sequence":"additional","affiliation":[]},{"given":"Ileana","family":"Filipescu","sequence":"additional","affiliation":[]},{"given":"Eva","family":"P\u00e9rez-Pampin","sequence":"additional","affiliation":[]},{"given":"Alfonso","family":"Gonz\u00e1lez-Utrilla","sequence":"additional","affiliation":[]},{"given":"Miguel \u00c1ngel L\u00f3pez","family":"Nevot","sequence":"additional","affiliation":[]},{"given":"Pablo","family":"Conesa-Zamora","sequence":"additional","affiliation":[]},{"given":"Alfons den","family":"Broeder","sequence":"additional","affiliation":[]},{"given":"Salvatore","family":"De Vita","sequence":"additional","affiliation":[]},{"given":"Sven Erik Hobe","family":"Jacobsen","sequence":"additional","affiliation":[]},{"given":"Eduardo","family":"Collantes-Estevez","sequence":"additional","affiliation":[]},{"given":"Luca","family":"Quartuccio","sequence":"additional","affiliation":[]},{"given":"Federico","family":"Canzian","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o E.","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Marieke J. H.","family":"Coenen","sequence":"additional","affiliation":[]},{"given":"Vibeke","family":"Andersen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-2423","authenticated-orcid":false,"given":"Juan","family":"Sainz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,10,5]]},"reference":[{"key":"57_CR1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jaut.2012.05.021","volume":"39","author":"MC Boissier","year":"2012","unstructured":"Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac\u2019h N, Falgarone G. Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. J Autoimmun. 2012;39:222\u20138.","journal-title":"J Autoimmun"},{"key":"57_CR2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nrrheum.2014.144","volume":"10","author":"GC Hughes","year":"2014","unstructured":"Hughes GC, Choubey D. Modulation of autoimmune rheumatic diseases by oestrogen and progesterone. Nat Rev Rheumatol. 2014;10:740\u201351.","journal-title":"Nat Rev Rheumatol"},{"key":"57_CR3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1196\/annals.1351.019","volume":"1069","author":"TK Kvien","year":"2006","unstructured":"Kvien TK, Uhlig T, Odegard S, Heiberg MS. Epidemiological aspects of rheumatoid arthritis: the sex ratio. Ann N Y Acad Sci. 2006;1069:212\u201322.","journal-title":"Ann N Y Acad Sci"},{"key":"57_CR4","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1002\/1529-0131(199906)42:6<1219::AID-ANR19>3.0.CO;2-G","volume":"42","author":"JH Barrett","year":"1999","unstructured":"Barrett JH, Brennan P, Fiddler M, Silman AJ. Does rheumatoid arthritis remit during pregnancy and relapse postpartum? Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy. Arthritis Rheum. 1999;42:1219\u201327.","journal-title":"Arthritis Rheum"},{"key":"57_CR5","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1136\/ard.2009.111179","volume":"69","author":"C Salliot","year":"2010","unstructured":"Salliot C, Bombardier C, Saraux A, Combe B, Dougados M. Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and\/or *04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort. Ann Rheum Dis. 2010;69:1683\u20136.","journal-title":"Ann Rheum Dis"},{"key":"57_CR6","first-page":"207","volume":"31","author":"MF Doran","year":"2004","unstructured":"Doran MF, Crowson CS, O\u2019Fallon WM, Gabriel SE. The effect of oral contraceptives and estrogen replacement therapy on the risk of rheumatoid arthritis: a population based study. J Rheumatol. 2004;31:207\u201313.","journal-title":"J Rheumatol"},{"key":"57_CR7","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/S8756-3282(01)00426-4","volume":"28","author":"D Yamasaki","year":"2001","unstructured":"Yamasaki D, Enokida M, Okano T, Hagino H, Teshima R. Effects of ovariectomy and estrogen replacement therapy on arthritis and bone mineral density in rats with collagen-induced arthritis. Bone. 2001;28:634\u201340.","journal-title":"Bone"},{"key":"57_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2174\/1568010043483944","volume":"3","author":"ML Salem","year":"2004","unstructured":"Salem ML. Estrogen, a double-edged sword: modulation of TH1- and TH2-mediated inflammations by differential regulation of TH1\/TH2 cytokine production. Curr Drug Targets Inflamm Allergy. 2004;3:97\u2013104.","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"57_CR9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/cmi.2010.54","volume":"8","author":"CY Luo","year":"2011","unstructured":"Luo CY, Wang L, Sun C, Li DJ. Estrogen enhances the functions of CD4(\u2009+\u2009)CD25(\u2009+\u2009)Foxp3(\u2009+\u2009) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro. Cell Mol Immunol. 2011;8:50\u201358.","journal-title":"Cell Mol Immunol"},{"key":"57_CR10","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.4049\/jimmunol.1101578","volume":"187","author":"K Lelu","year":"2011","unstructured":"Lelu K, Laffont S, Delpy L, Paulet PE, Perinat T, Tschanz SA, et al. Estrogen receptor alpha signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis. J Immunol. 2011;187:2386\u201393.","journal-title":"J Immunol"},{"key":"57_CR11","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/jcp.21221","volume":"214","author":"P Tai","year":"2008","unstructured":"Tai P, Wang J, Jin H, Song X, Yan J, Kang Y, et al. Induction of regulatory T cells by physiological level estrogen. J Cell Physiol. 2008;214:456\u201364.","journal-title":"J Cell Physiol"},{"key":"57_CR12","doi-asserted-by":"publisher","first-page":"R101","DOI":"10.1186\/ar3032","volume":"12","author":"J Dulos","year":"2010","unstructured":"Dulos J, Vijn P, van Doorn C, Hofstra CL, Veening-Griffioen D, de Graaf J, et al. Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta. Arthritis Res Ther. 2010;12:R101.","journal-title":"Arthritis Res Ther"},{"key":"57_CR13","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1007\/s00296-011-1947-2","volume":"32","author":"H Sato","year":"2012","unstructured":"Sato H, Ito A, Gonzalez-Canga A, Okuzawa H, Ugai K, Suzuki M, et al. Association of Rsa polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis. Rheumatol Int. 2012;32:2143\u20138.","journal-title":"Rheumatol Int"},{"key":"57_CR14","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/03009742.2011.563752","volume":"40","author":"V Dziedziejko","year":"2011","unstructured":"Dziedziejko V, Kurzawski M, Safranow K, Drozdzik M, Chlubek D, Pawlik A. Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis. Scand J Rheumatol. 2011;40:329\u201333.","journal-title":"Scand J Rheumatol"},{"key":"57_CR15","doi-asserted-by":"publisher","first-page":"R97","DOI":"10.1186\/ar2742","volume":"11","author":"EW Karlson","year":"2009","unstructured":"Karlson EW, Chibnik LB, McGrath M, Chang SC, Keenan BT, Costenbader KH, et al. A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis. Arthritis Res Ther. 2009;11:R97.","journal-title":"Arthritis Res Ther"},{"key":"57_CR16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S1734-1140(12)70745-4","volume":"64","author":"A Pawlik","year":"2012","unstructured":"Pawlik A, Dziedziejko V, Kurzawski M, Safranow K, Kotrych D, Bohatyrewicz A. Effect of ESR1 and ESR2 gene polymorphisms on rheumatoid arthritis treatment with methotrexate. Pharmacol Rep. 2012;64:185\u201390.","journal-title":"Pharmacol Rep"},{"key":"57_CR17","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315\u201324.","journal-title":"Arthritis Rheum"},{"key":"57_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/art.1780390105","volume":"39","author":"AM Gestel van","year":"1996","unstructured":"van Gestel AM, Prevoo ML, van \u2018t Hof MA, van Rijswijk MH, van de Putte LB, van Riel PL. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization\/International League Against Rheumatism Criteria. Arthritis Rheum. 1996;39:34\u201340.","journal-title":"Arthritis Rheum"},{"key":"57_CR19","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/FPC.0000000000000155","volume":"25","author":"LM Canet","year":"2015","unstructured":"Canet LM, Filipescu I, C\u00e1liz R, Lupia\u00f1ez CB, Canh\u00e3o H, Escudero A, et al. Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study. Pharm Genom. 2015;25:432\u201343.","journal-title":"Pharm Genom"},{"key":"57_CR20","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/FPC.0000000000000155","volume":"25","author":"LM Canet","year":"2015","unstructured":"Canet LM, C\u00e1liz R, Lupia\u00f1ez CB, Canh\u00e3o H, Martinez M, Escudero A, et al. Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study. Pharm Genom. 2015;25:432\u201343.","journal-title":"Pharm Genom"},{"key":"57_CR21","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1086\/383251","volume":"74","author":"DR Nyholt","year":"2004","unstructured":"Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet. 2004;74:765\u20139.","journal-title":"Am J Hum Genet"},{"key":"57_CR22","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1093\/bioinformatics\/btl268","volume":"22","author":"X Sole","year":"2006","unstructured":"Sole X, Guino E, Valls J, Iniesta R, Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics. 2006;22:1928\u20139.","journal-title":"Bioinformatics"},{"key":"57_CR23","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1126\/science.1069424","volume":"296","author":"SB Gabriel","year":"2002","unstructured":"Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. The structure of haplotype blocks in the human genome. Science. 2002;296:2225\u20139.","journal-title":"Science"},{"key":"57_CR24","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/004982598239290","volume":"28","author":"T Niwa","year":"1998","unstructured":"Niwa T, Yabusaki Y, Honma K, Matsuo N, Tatsuta K, Ishibashi F, et al. Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998;28:539\u201347.","journal-title":"Xenobiotica"},{"key":"57_CR25","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/978-1-59259-781-9","volume-title":"Handbook of drug-nutrient interactions","author":"JI Boullata","year":"2004","unstructured":"Boullata JI, Armenti VT. Handbook of drug-nutrient interactions. xvii. Totowa, NJ: Humana Press; 2004. p. 563."},{"key":"57_CR26","doi-asserted-by":"publisher","first-page":"e1002025","DOI":"10.1371\/journal.pgen.1002025","volume":"7","author":"G Zhai","year":"2011","unstructured":"Zhai G, Teumer A, Stolk L, Perry JR, Vandenput L, Coviello AD, et al. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet. 2011;7:e1002025.","journal-title":"PLoS Genet"},{"key":"57_CR27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/jmcb\/mju005","volume":"6","author":"J Yan","year":"2014","unstructured":"Yan J, Li Q, Mao AP, Hu MM, Shu HB. TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination. J Mol Cell Biol. 2014;6:154\u201363.","journal-title":"J Mol Cell Biol"},{"key":"57_CR28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1476-5381.2008.00050.x","volume":"156","author":"NJ Liptrott","year":"2009","unstructured":"Liptrott NJ, Penny M, Bray PG, Sathish J, Khoo SH, Back DJ, et al. The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC. Br J Pharmacol. 2009;156:497\u2013508.","journal-title":"Br J Pharmacol"},{"key":"57_CR29","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.dmpk.2014.09.004","volume":"30","author":"H Mimura","year":"2015","unstructured":"Mimura H, Kobayashi K, Xu L, Hashimoto M, Ejiri Y, Hosoda M, et al. Effects of cytokines on CYP3A4 expression and reversal of the effects by anti-cytokine agents in the three-dimensionally cultured human hepatoma cell line FLC-4. Drug Metab Pharmacokinet. 2015;30:105\u201310.","journal-title":"Drug Metab Pharmacokinet"},{"key":"57_CR30","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12531","volume":"501","author":"T Lappalainen","year":"2013","unstructured":"Lappalainen T, Sammeth M, Friedlander MR, t Hoen PA, Monlong J, Rivas MA, et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature. 2013;501:506\u201311.","journal-title":"Nature"},{"key":"57_CR31","first-page":"820","volume":"81","author":"M Cutolo","year":"1996","unstructured":"Cutolo M, Accardo S, Villaggio B, Barone A, Sulli A, Coviello DA, et al. Androgen and estrogen receptors are present in primary cultures of human synovial macrophages. J Clin Endocrinol Metab. 1996;81:820\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"57_CR32","first-page":"2309","volume":"86","author":"S Bord","year":"2001","unstructured":"Bord S, Horner A, Beavan S, Compston J. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J Clin Endocrinol Metab. 2001;86:2309\u201314.","journal-title":"J Clin Endocrinol Metab"},{"key":"57_CR33","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/art.1780360809","volume":"36","author":"M Cutolo","year":"1993","unstructured":"Cutolo M, Accardo S, Villaggio B, Clerico P, Bagnasco M, Coviello DA, et al. Presence of estrogen-binding sites on macrophage-like synoviocytes and CD8+, CD29+, CD45RO+T lymphocytes in normal and rheumatoid synovium. Arthritis Rheum. 1993;36:1087\u201397.","journal-title":"Arthritis Rheum"},{"key":"57_CR34","doi-asserted-by":"publisher","first-page":"897","DOI":"10.7326\/0003-4819-130-11-199906010-00005","volume":"130","author":"RR Recker","year":"1999","unstructured":"Recker RR, Davies KM, Dowd RM, Heaney RP. The effect of low-dose continuous estrogen and progesterone therapy with calcium and vitamin D on bone in elderly women. A randomized, controlled trial. Ann Intern Med. 1999;130:897\u2013904.","journal-title":"Ann Intern Med"},{"key":"57_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1749-6632.1999.tb07630.x","volume":"876","author":"M Ostensen","year":"1999","unstructured":"Ostensen M. Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Ann N Y Acad Sci. 1999;876:131\u201343. discussion 144","journal-title":"Ann N Y Acad Sci"},{"key":"57_CR36","first-page":"1620","volume":"17","author":"S Goemaere","year":"1990","unstructured":"Goemaere S, Ackerman C, Goethals K, De Keyser F, Van der Straeten C, Verbruggen G, et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol. 1990;17:1620\u20132.","journal-title":"J Rheumatol"},{"key":"57_CR37","first-page":"1809","volume":"28","author":"S Kuiper","year":"2001","unstructured":"Kuiper S, van Gestel AM, Swinkels HL, de Boo TM, da Silva JA, van Riel PL. Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. J Rheumatol. 2001;28:1809\u201316.","journal-title":"J Rheumatol"},{"key":"57_CR38","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","volume":"294","author":"S Kovats","year":"2015","unstructured":"Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. 2015;294:63\u201369.","journal-title":"Cell Immunol"},{"key":"57_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1046\/j.1365-2567.2001.01212.x","volume":"103","author":"MC Erlandsson","year":"2001","unstructured":"Erlandsson MC, Ohlsson C, Gustafsson JA, Carlsten H. Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus. Immunology. 2001;103:17\u201325.","journal-title":"Immunology"},{"key":"57_CR40","doi-asserted-by":"publisher","first-page":"6023","DOI":"10.4049\/jimmunol.174.10.6023","volume":"174","author":"R Mo","year":"2005","unstructured":"Mo R, Chen J, Grolleau-Julius A, Murphy HS, Richardson BC, Yung RL. Estrogen regulates CCR gene expression and function in T lymphocytes. J Immunol. 2005;174:6023\u20139.","journal-title":"J Immunol"},{"key":"57_CR41","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1749-6632.1999.tb07628.x","volume":"876","author":"JA Silva Da","year":"1999","unstructured":"Da Silva JA. Sex hormones and glucocorticoids: interactions with the immune system. Ann N Y Acad Sci. 1999;876:102\u201317. discussion 117-108","journal-title":"Ann N Y Acad Sci"},{"key":"57_CR42","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1182\/blood.V95.6.2059","volume":"95","author":"KL Medina","year":"2000","unstructured":"Medina KL, Strasser A, Kincade PW. Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors. Blood. 2000;95:2059\u201367.","journal-title":"Blood"},{"key":"57_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0928-8244(03)00202-5","volume":"38","author":"KW Beagley","year":"2003","unstructured":"Beagley KW, Gockel CM. Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol Med Microbiol. 2003;38:13\u201322.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"57_CR44","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13075-015-0548-y","volume":"17","author":"A Andersson","year":"2015","unstructured":"Andersson A, Stubelius A, Karlsson MN, Engdahl C, Erlandsson M, Grahnemo L, et al. Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis. Arthritis Res Ther. 2015;17:32.","journal-title":"Arthritis Res Ther"},{"key":"57_CR45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/FPC.0b013e3283349e84","volume":"20","author":"D Booven Van","year":"2010","unstructured":"Van Booven D, Marsh S, McLeod H, Carrillo MW, Sangkuhl K, Klein TE, et al. Cytochrome P450 2C9-CYP2C9. Pharm Genom. 2010;20:277\u201381.","journal-title":"Pharm Genom"},{"key":"57_CR46","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/00008571-199608000-00007","volume":"6","author":"TH Sullivan-Klose","year":"1996","unstructured":"Sullivan-Klose TH, Ghanayem BI, Bell DA, Zhang ZY, Kaminsky LS, Shenfield GM, et al. The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics. 1996;6:341\u20139.","journal-title":"Pharmacogenetics"},{"key":"57_CR47","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/rheumatology\/kev421","volume":"55","author":"BV Cuppen","year":"2016","unstructured":"Cuppen BV, Welsing PM, Sprengers JJ, Bijlsma JW, Marijnissen AC, van Laar JM, et al. Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability. Rheumatol (Oxf). 2016;55:826\u201339.","journal-title":"Rheumatol (Oxf)"},{"key":"57_CR48","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2119\/2008-00056.Liu","volume":"14","author":"C Liu","year":"2008","unstructured":"Liu C, Batliwalla F, Li W, Lee A, Roubenoff R, Beckman E, et al. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Mol Med. 2008;14:575\u201381.","journal-title":"Mol Med"},{"key":"57_CR49","doi-asserted-by":"publisher","first-page":"727","DOI":"10.2217\/pgs.13.60","volume":"14","author":"I Acosta-Colman","year":"2013","unstructured":"Acosta-Colman I, Palau N, Tornero J, Fernandez-Nebro A, Blanco F, Gonzalez-Alvaro I, et al. GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics. 2013;14:727\u201334.","journal-title":"Pharmacogenomics"},{"key":"57_CR50","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/art.33381","volume":"64","author":"D Plant","year":"2012","unstructured":"Plant D, Prajapati R, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, et al. Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort. Arthritis Rheum. 2012;64:665\u201370.","journal-title":"Arthritis Rheum"},{"key":"57_CR51","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/art.27457","volume":"62","author":"J Cui","year":"2010","unstructured":"Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, et al. Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum. 2010;62:1849\u201361.","journal-title":"Arthritis Rheum"},{"key":"57_CR52","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/art.30130","volume":"63","author":"D Plant","year":"2011","unstructured":"Plant D, Bowes J, Potter C, Hyrich KL, Morgan AW, Wilson AG, et al. Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci. Arthritis Rheum. 2011;63:645\u201353.","journal-title":"Arthritis Rheum"},{"key":"57_CR53","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1136\/annrheumdis-2012-202405","volume":"72","author":"M Umicevic Mirkov","year":"2013","unstructured":"Umicevic Mirkov M, Cui J, Vermeulen SH, Stahl EA, Toonen EJ, Makkinje RR, et al. Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis. Ann Rheum Dis. 2013;72:1375\u201381.","journal-title":"Ann Rheum Dis"}],"updated-by":[{"DOI":"10.1038\/s41397-019-0084-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000}}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41397-018-0057-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41397-018-0057-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41397-018-0057-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T20:14:19Z","timestamp":1720642459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41397-018-0057-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,5]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["57"],"URL":"https:\/\/doi.org\/10.1038\/s41397-018-0057-x","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"value":"1470-269X","type":"print"},{"value":"1473-1150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,5]]},"assertion":[{"value":"29 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2019","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version of this Article contained an error in the spelling of the author Ana Rodr\u00edguez-Ramos, which was incorrectly given as Ana Rodr\u00edguez Ramos. This has now been corrected in both the PDF and HTML versions of the Article.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"VA has received compensation for consultancy and for being a member of an advisory board from MSD (Merck) and Janssen. All other authors declare that they have no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}