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Different brain regions coordinate this complex decision, including the nucleus accumbens (NAc), anterior cingulate cortex (ACC), and ventral tegmental area (VTA). <jats:italic>In utero<\/jats:italic> exposure to synthetic glucocorticoids (iuGC), such as dexamethasone, triggers prominent motivation deficits but the impact of this exposure in the ACC-NAc and\/or ACC-VTA circuits is unknown. Here, we show that iuGC exposure causes decreased motivation for natural rewards (food) and impaired effort-based decision-making. Importantly, reduced neuronal activation (number of c-fos<jats:sup>+<\/jats:sup> neurons) was observed in the NAc core and ACC of iuGC rats in comparison to CTR rats after performing the effort-based decision-making task. In addition, iuGC treatment led to increased NAc and ACC basal neuronal activity. Electrophysiological recordings during optogenetic modulation of ACC terminals in the NAc revealed that the ACC-NAc circuit is dysfunctional in iuGC animals. These data suggest that iuGC animals present motivational and effort-based decision-making deficits that can be associated with the observed ACC-NAc dysfunction.<\/jats:p>","DOI":"10.1038\/s41398-022-02043-4","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T08:03:09Z","timestamp":1660896189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rats"],"prefix":"10.1038","volume":"12","author":[{"given":"Ana Ver\u00f3nica","family":"Domingues","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-2268","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Coimbra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-858X","authenticated-orcid":false,"given":"Raquel","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Deseyve","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-0046","authenticated-orcid":false,"given":"Natacha","family":"Vieitas-Gaspar","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5633-243X","authenticated-orcid":false,"given":"Stan B.","family":"Floresco","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-5126","authenticated-orcid":false,"given":"Nuno","family":"Sousa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-644X","authenticated-orcid":false,"given":"Carina","family":"Soares-Cunha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-7968","authenticated-orcid":false,"given":"Ana Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"2043_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0006-8993(92)90809-N","volume":"574","author":"LK Takahashi","year":"1992","unstructured":"Takahashi LK, Turner JG, Kalin NH. 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