{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:18:52Z","timestamp":1768011532762,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br Dent J"],"published-print":{"date-parts":[[2021,10,8]]},"DOI":"10.1038\/s41415-021-3476-z","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T01:29:42Z","timestamp":1633742982000},"page":"387-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Resin infiltration in white spot lesions caused by orthodontic hypomineralisation: a minimally invasive therapy"],"prefix":"10.1038","volume":"231","author":[{"given":"Maria In\u00eas","family":"Tavares","sequence":"first","affiliation":[]},{"given":"Jos\u00e9","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"do Vale","sequence":"additional","affiliation":[]},{"given":"Ana Sofia","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"In\u00eas Flores","family":"Amaro","sequence":"additional","affiliation":[]},{"given":"Carlos Miguel","family":"Marto","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Francisco","sequence":"additional","affiliation":[]},{"given":"Manuel Marques","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Anabela Baptista","family":"Paula","sequence":"additional","affiliation":[]},{"given":"Eunice Virg\u00ednia","family":"Carrilho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"3476_CR6503","doi-asserted-by":"crossref","unstructured":"Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A. Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: A meta-analysis. J Int Soc Prev Community Dent 2015; 5: 433.","DOI":"10.4103\/2231-0762.167719"},{"key":"3476_CR6506","doi-asserted-by":"crossref","unstructured":"Guo L, Shi W. Salivary biomarkers for caries risk assessment. J Calif Dent Assoc 2013; 41: 107-109, 112-118.","DOI":"10.1080\/19424396.2013.12222284"},{"key":"3476_CR6508","doi-asserted-by":"crossref","unstructured":"Paula A B P, Fernandes A R, Coelho A S et al. Therapies for White Spot Lesions - A Systematic Review. J Evid Based Dent Pract 2017; 17: 23-38.","DOI":"10.1016\/j.jebdp.2016.10.003"},{"key":"3476_CR6510","unstructured":"Abdullah Z, John J. Minimally Invasive Treatment of White Spot Lesions-A Systematic Review. Oral Health Prev Dent 2016; 14: 197-205."},{"key":"3476_CR6512","doi-asserted-by":"crossref","unstructured":"Kn\u00f6sel M, Eckstein A, Helms H J. Durability of esthetic improvement following Icon resin infiltration of multibracket-induced white spot lesions compared with no therapy over 6 months: A single-centre, split-mouth, randomized clinical trial. Am J Orthod Dentofac Orthop 2013; 144: 86-96.","DOI":"10.1016\/j.ajodo.2013.02.029"},{"key":"3476_CR6515","doi-asserted-by":"crossref","unstructured":"Chapman J A, Roberts W E, Eckert G J, Kula K S, Gonz\u00e1lez-Cabezas C. Risk factors for incidence and severity of white spot lesions during treatment with fixed orthodontic appliances. Am J Orthod Dentofac Orthop 2010; 138: 188-194.","DOI":"10.1016\/j.ajodo.2008.10.019"},{"key":"3476_CR6517","unstructured":"Behrouzi P, Heshmat H, Hoorizad Ganjkar M, Tabatabaei S F, Kharazifard M J. Effect of Two Methods of Remineralization and Resin Infiltration on Surface Hardness of Artificially Induced Enamel Lesions. J Dent (Shiraz) 2020; 21: 12-17."},{"key":"3476_CR6519","doi-asserted-by":"crossref","unstructured":"Tufekci E, Dixon J S, Gunsolley J C, Lindauer S J. Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod 2011; 81: 206-210.","DOI":"10.2319\/051710-262.1"},{"key":"3476_CR6521","doi-asserted-by":"crossref","unstructured":"Benson P E, Parkin N, Dyer F, Millett D T, Furness S, Germain P. Fluorides for the prevention of early tooth decay (demineralised white lesions) during fixed brace treatment. Cochrane Database Syst Rev 2013; DOI: 10.1002\/14651858.CD003809.pub3.","DOI":"10.1002\/14651858.CD003809.pub3"},{"key":"3476_CR6523","doi-asserted-by":"crossref","unstructured":"Yap J, Walsh L J, Naser-Ud Din S, Ngo H, Manton D J. Evaluation of a novel approach in the prevention of white spot lesions around orthodontic brackets. Aust Dent J 2014; 59: 70-80.","DOI":"10.1111\/adj.12142"},{"key":"3476_CR6526","doi-asserted-by":"crossref","unstructured":"Morrier J-J. White spot lesions and orthodontic treatment. Prevention and treatment. Orthod Fr 2014; 85: 235-244.","DOI":"10.1051\/orthodfr\/2014016"},{"key":"3476_CR6528","doi-asserted-by":"crossref","unstructured":"Cazzolla A P, De Franco A R, Lacaita M, Lacarbonara V. Efficacy of 4-year treatment of icon infiltration resin on postorthodontic white spot lesions. BMJ Case Rep 2018; DOI: 10.1136\/bcr-2018-225639.","DOI":"10.1136\/bcr-2018-225639"},{"key":"3476_CR6530","doi-asserted-by":"crossref","unstructured":"Khoroushi M, Kachuie M. Prevention and treatment of white spot lesions in orthodontic patients. Contemp Clin Dent 2017; 8: 11-19.","DOI":"10.4103\/ccd.ccd_216_17"},{"key":"3476_CR6532","doi-asserted-by":"crossref","unstructured":"Amaechi B T. Remineralisation - The buzzword for early MI caries management. Br Dent J 2017; 223: 173-182.","DOI":"10.1038\/sj.bdj.2017.663"},{"key":"3476_CR6534","unstructured":"G\u00f6zetici B, \u00d6zt\u00fcrk-Bozkurt F, Toz-Akal\u0131n T. Comparative Evaluation of Resin Infiltration and Remineralisation of Noncavitated Smooth Surface Caries Lesions: 6-month Results. Oral Health Prev Dent 2019; 17: 99-106."},{"key":"3476_CR6537","doi-asserted-by":"crossref","unstructured":"Subramaniam P, Girish Babu K L, Lakhotia D. Evaluation of penetration depth of a commercially available resin infiltrate into artificially created enamel lesions: An in vitro study. J Conserv Dent 2014; 17: 146-149.","DOI":"10.4103\/0972-0707.128054"},{"key":"3476_CR6539","doi-asserted-by":"crossref","unstructured":"Laleman I, Detailleur V, Slot D E, Slomka V, Quirynen M, Teughels W. Probiotics reduce mutans streptococci counts in humans: A systematic review and meta-analysis. Clin Oral Investig 2014; 18: 1539-1552.","DOI":"10.1007\/s00784-014-1228-z"},{"key":"3476_CR6542","doi-asserted-by":"crossref","unstructured":"Tirali R E, Bodur H, Ece G. In vitro antimicrobial activity of Sodium hypochlorite, Chlorhexidine gluconate and Octenidine Dihydrochloride in elimination of microor-ganisms within dentinal tubules of primary and permanent teeth. Med Oral Patol Oral Cir Bucal 2012; DOI: 10.4317\/medoral.17566.","DOI":"10.4317\/medoral.17566"},{"key":"3476_CR6544","doi-asserted-by":"crossref","unstructured":"Makinen K K, Pape H R, Makinen P L, Bennett C A, Isotupa K P, Isokangas P J. Xylitol Chewing Gums and Caries Rates: A 40-month Cohort Study. J Dent Res 1995; 74: 1904-1913.","DOI":"10.1177\/00220345950740121501"},{"key":"3476_CR6546","doi-asserted-by":"crossref","unstructured":"Milgrom P, S\u00f6derling E M, Nelson S, Chi D L, Nakai Y. Clinical evidence for polyol efficacy. Adv Dent Res 2012; 24: 112-116.","DOI":"10.1177\/0022034512449467"},{"key":"3476_CR6550","doi-asserted-by":"crossref","unstructured":"Hu W, Featherstone J D B. Prevention of enamel demineralization: An in-vitro study using light-cured filled sealant. Am J Orthod Dentofac Orthop 2005; 128: 592-600.","DOI":"10.1016\/j.ajodo.2004.07.046"},{"key":"3476_CR6552","doi-asserted-by":"crossref","unstructured":"O'Reilly M T, De Jesus Vinas J, Hatch J P. Effectiveness of a sealant compared with no sealant in preventing enamel demineralization in patients with fixed orthodontic appliances: a prospective clinical trial. Am J Orthod Dentofacial Orthop 2013; 143: 837-844.","DOI":"10.1016\/j.ajodo.2013.01.021"},{"key":"3476_CR6554","doi-asserted-by":"crossref","unstructured":"de Freitas P M, Rapozo-Hilo M, Eduardo C de P, Featherstone J D B. In vitro evaluation of erbium, chromium: yttrium-scandium-gallium-garnet laser-treated enamel demineralization. Lasers Med Sci 2010; 25: 165-170.","DOI":"10.1007\/s10103-008-0597-4"},{"key":"3476_CR6556","doi-asserted-by":"crossref","unstructured":"Kn\u00f6sel M, Attin R, Becker K, Attin T. External bleaching effect on the colour and luminosity of inactive white-spot lesions after fixed orthodontic appliances. Angle Orthod 2007; 77: 646-652.","DOI":"10.2319\/060106-224"},{"key":"3476_CR6559","doi-asserted-by":"crossref","unstructured":"Bussadori S K, Do Rego M A, Da Silva P E, Pinto M M, Pinto A C G. Esthetic alternative for fluorosis blemishes with the usage of a dual bleaching system based on hydrogen peroxide at 35%. J Clin Pediatr Dent 2004; 28: 143-146.","DOI":"10.17796\/jcpd.28.2.g45173lp7661g078"},{"key":"3476_CR6561","unstructured":"Ardu S, Castioni N V, Benbachir N, Krejci I. Minimally invasive treatment of white spot enamel lesions. Quintessence Int 2007; 38: 633-636."},{"key":"3476_CR6563","doi-asserted-by":"crossref","unstructured":"Donly K J, Sasa S I. Potential Remineralization of Postorthodontic Demineralized Enamel and the Use of Enamel Microabrasion and Bleaching for Esthetics. Semin Orthod 2008; 14: 220-225.","DOI":"10.1053\/j.sodo.2008.03.007"},{"key":"3476_CR6565","unstructured":"Jahanbin A, Ameri H, Shahabi M, Ghazi A. Management of Post-orthodontic White Spot Lesions and Subsequent Enamel Discoloration with Two Microabrasion Techniques. J Dent (Shiraz) 2015; 16: 56-60."},{"key":"3476_CR6567","doi-asserted-by":"crossref","unstructured":"Ntovas P, Rahiotis C. A clinical guideline for caries infiltration of proximal enamel lesions with resins. Br Dent J 2018; 225: 299-304.","DOI":"10.1038\/sj.bdj.2018.647"},{"key":"3476_CR6570","doi-asserted-by":"crossref","unstructured":"Enan E T, Aref N S, Hammad S M. Resistance of resin-infiltrated enamel to surface changes in response to acidic challenge. J Esthet Restor Dent 2019; 31: 353-358.","DOI":"10.1111\/jerd.12471"},{"key":"3476_CR6573","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz M A, Arana-Gordillo L A, Gomes G M et al. Alternative esthetic management of fluorosis and hypoplasia stains: Blending effect obtained with resin infiltration techniques. J Esthet Restor Dent 2013; 25: 32-39.","DOI":"10.1111\/j.1708-8240.2012.00527.x"},{"key":"3476_CR6575","doi-asserted-by":"crossref","unstructured":"Aziznezhad M, Alaghemand H, Shahande Z et al. Comparison of the effect of resin infiltrant, fluoride varnish, and nano-hydroxy apatite paste on surface hardness and streptococcus mutans adhesion to artificial enamel lesions. Electron Physician 2017; 9: 3934-3942.","DOI":"10.19082\/3934"},{"key":"3476_CR6578","doi-asserted-by":"crossref","unstructured":"Anand V, Arumugam S B, Manoharan V, Kumar S A, Methippara J J. Is Resin Infiltration a Microinvasive Approach to White Lesions of Calcified Tooth Structures?: A Systemic Review. Int J Clin Pediatr Dent 2019; 12: 53-58.","DOI":"10.5005\/jp-journals-10005-1579"},{"key":"3476_CR6580","doi-asserted-by":"crossref","unstructured":"Cazzolla A P, De Franco A R, Lacaita M L V. Efficacy of 4-year treatment of icon infiltration resin on postorthodontic white spot lesions. BMJ Case Rep 2018; DOI: 10.1136\/bcr-2018-225639.","DOI":"10.1136\/bcr-2018-225639"},{"key":"3476_CR6582","doi-asserted-by":"crossref","unstructured":"Ekizer A, Zorba Y O, Uysal T, Ayrikcil S. Effects of demineralizaton-inhibition procedures on the bond strength of brackets bonded to demineralized enamel surface. Korean J Orthod 2012; 42: 17-22.","DOI":"10.4041\/kjod.2012.42.1.17"},{"key":"3476_CR6584","doi-asserted-by":"crossref","unstructured":"Mandava J, Reddy Y S, Kantheti S et al. Microhardness and Penetration of Artificial White Spot Lesions Treated with Resin or Colloidal Silica Infiltration. J Clin Diagn Res 2017; DOI: 10.7860\/JCDR\/2017\/25512.9706.","DOI":"10.7860\/JCDR\/2017\/25512.9706"},{"key":"3476_CR6586","doi-asserted-by":"crossref","unstructured":"Dorri M, Dunne S M, Walsh T, Schwendicke F. Micro-invasive interventions for managing proximal dental decay in primary and permanent teeth. Cochrane Database Syst Rev 2015; DOI: 10.1002\/14651858.CD010431.pub2.","DOI":"10.1002\/14651858.CD010431.pub2"},{"key":"3476_CR6589","doi-asserted-by":"crossref","unstructured":"Elrashid A H, Alshaiji B S, Saleh S A, Zada K A, Baseer M A. Efficacy of Resin Infiltrate in Noncavitated Proximal Carious Lesions: A Systematic Review and Meta-Analysis. J Int Soc Prev Community Dent 2019; 9: 211-218.","DOI":"10.4103\/jispcd.JISPCD_26_19"},{"key":"3476_CR6591","unstructured":"Kielbassa A M, Muller J, Gernhardt C R. Closing the gap between oral hygiene and minimally invasive dentistry: a review on the resin infiltration technique of incipient (proximal) enamel lesions. Quintessence Int 2009; 40: 663-681."},{"key":"3476_CR6593","doi-asserted-by":"crossref","unstructured":"Domejean S, Ducamp R, L\u00e9ger S, Holmgren C. Resin infiltration of non-cavitated caries lesions: A systematic review. Med Princ Pract 2015; 24: 216-221.","DOI":"10.1159\/000371709"},{"key":"3476_CR6596","doi-asserted-by":"crossref","unstructured":"Knosel M, Eckstein A, Helms H-J. Long-term follow-up of camouflage effects following resin infiltration of post orthodontic white-spot lesions in vivo. Angle Orthod 2019; 89: 33-39.","DOI":"10.2319\/052118-383.1"},{"key":"3476_CR6598","doi-asserted-by":"crossref","unstructured":"Borges A B, Caneppele T M F, Masterson D, Maia L C. Is resin infiltration an effective esthetic treatment for enamel development defects and white spot lesions? A systematic review. J Dent 2017; 56: 11-18.","DOI":"10.1016\/j.jdent.2016.10.010"},{"key":"3476_CR6601","doi-asserted-by":"crossref","unstructured":"Kielbassa A M, Leimer M R, Hartmann J, Harm S, Pasztorek M, Ulrich I B. Ex vivo investigation on internal tunnel approach\/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin. PLoS One 2020; DOI: 10.1371\/journal.pone.0228249.","DOI":"10.1371\/journal.pone.0228249"},{"key":"3476_CR6603","doi-asserted-by":"crossref","unstructured":"Prasada K, Penta P, Ramya K. Spectrophotometric evaluation of white spot lesion treatment using novel resin infiltration material (Icon). J Conserv Dent 2018; 21: 531.","DOI":"10.4103\/JCD.JCD_52_18"},{"key":"3476_CR6605","doi-asserted-by":"crossref","unstructured":"Gu X, Yang L, Yang D et al. Esthetic improvements of postorthodontic white-spot lesions treated with resin infiltration and microabrasion: A split-mouth, randomized clinical trial. Angle Orthod 2019; 89: 372-377.","DOI":"10.2319\/041218-274.1"},{"key":"3476_CR6607","doi-asserted-by":"crossref","unstructured":"Schnabl D, Dudasne-Orosz V, Glueckert R, Handschuh S, Kapferer-Seebacher I, Dumfahrt H. Testing the Clinical Applicability of Resin Infiltration of Developmental Enamel Hypomineralization Lesions Using an In Vitro Model. Int J Clin Pediatr Dent 2019; 12: 126-132.","DOI":"10.5005\/jp-journals-10005-1609"}],"container-title":["British Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41415-021-3476-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41415-021-3476-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41415-021-3476-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T16:13:55Z","timestamp":1699632835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41415-021-3476-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,10,8]]}},"alternative-id":["3476"],"URL":"https:\/\/doi.org\/10.1038\/s41415-021-3476-z","relation":{},"ISSN":["0007-0610","1476-5373"],"issn-type":[{"value":"0007-0610","type":"print"},{"value":"1476-5373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,8]]},"assertion":[{"value":"23 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}}]}}