{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:59:48Z","timestamp":1740124788802,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1038\/s41418-021-00856-2","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T17:48:26Z","timestamp":1630432106000},"page":"2983-2985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The quest for the \u201cHOIL-1\u201d grail of T-cell development"],"prefix":"10.1038","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1567-8389","authenticated-orcid":false,"given":"Nuno L.","family":"Alves","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Ferreirinha","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"856_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev-immunol-051116-052320","volume":"35","author":"J Abramson","year":"2017","unstructured":"Abramson J, Anderson G. Thymic epithelial cells. Annu Rev Immunol. 2017;35:85\u2013118.","journal-title":"Annu Rev Immunol"},{"key":"856_CR2","doi-asserted-by":"publisher","unstructured":"Jain R, Zhao K, Sheridan JM, Heinlein M, Kupresanin F, Abeysekera W, et al. Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death Differ. 2021. https:\/\/doi.org\/10.1038\/s41418-021-00850-8. [Epub ahead of print].","DOI":"10.1038\/s41418-021-00850-8"},{"key":"856_CR3","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41418-020-00702-x","volume":"28","author":"BK Fiil","year":"2021","unstructured":"Fiil BK, Gyrd-Hansen M. The Met1-linked ubiquitin machinery in inflammation and infection. Cell Death Differ. 2021;28:557\u201369.","journal-title":"Cell Death Differ"},{"key":"856_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.it.2009.11.002","volume":"31","author":"M Irla","year":"2010","unstructured":"Irla M, Hollander G, Reith W. Control of central self-tolerance induction by autoreactive CD4+ thymocytes. Trends Immunol. 2010;31:71\u20139.","journal-title":"Trends Immunol"},{"key":"856_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.smim.2005.02.002","volume":"17","author":"AR Almeida","year":"2005","unstructured":"Almeida AR, Rocha B, Freitas AA, Tanchot C. Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Semin Immunol. 2005;17:239\u201349.","journal-title":"Semin Immunol"},{"key":"856_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.it.2012.03.005","volume":"33","author":"G Anderson","year":"2012","unstructured":"Anderson G, Takahama Y. Thymic epithelial cells: working class heroes for T cell development and repertoire selection. Trends Immunol. 2012;33:256\u201363.","journal-title":"Trends Immunol"},{"key":"856_CR7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/eji.201646329","volume":"46","author":"NL Alves","year":"2016","unstructured":"Alves NL, Ribeiro AR. Thymus medulla under construction: time and space oddities. Eur J Immunol. 2016;46:829\u201333.","journal-title":"Eur J Immunol"},{"key":"856_CR8","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.it.2021.05.003","volume":"42","author":"L Verboom","year":"2021","unstructured":"Verboom L, Hoste E, van Loo G. OTULIN in NF-kappaB signaling, cell death, and disease. Trends Immunol. 2021;42:590\u2013603.","journal-title":"Trends Immunol"},{"key":"856_CR9","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1182\/blood-2016-12-758961","volume":"130","author":"PM Rodrigues","year":"2017","unstructured":"Rodrigues PM, Ribeiro AR, Perrod C, Landry JJM, Araujo L, Pereira-Castro I, et al. Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice. Blood. 2017;130:478\u201388.","journal-title":"Blood."},{"key":"856_CR10","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","volume":"137","author":"KH Vousden","year":"2009","unstructured":"Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell. 2009;137:413\u201331.","journal-title":"Cell."}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41418-021-00856-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41418-021-00856-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41418-021-00856-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:15:51Z","timestamp":1632960951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41418-021-00856-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["856"],"URL":"https:\/\/doi.org\/10.1038\/s41418-021-00856-2","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"type":"print","value":"1350-9047"},{"type":"electronic","value":"1476-5403"}],"subject":[],"published":{"date-parts":[[2021,8,31]]},"assertion":[{"value":"12 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}