{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:09:05Z","timestamp":1773353345723,"version":"3.50.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849<jats:italic>, P<\/jats:italic>\u2009=\u20091.52\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895,<jats:italic>P<\/jats:italic>\u2009=\u20099.43\u2009\u00d7\u200910<jats:sup>\u221217<\/jats:sup>), 6q23.3 (rs6928977,<jats:italic>P<\/jats:italic>\u2009=\u20094.62\u2009\u00d7\u200910<jats:sup>\u221211<\/jats:sup>), 10p14 (rs3781093,<jats:italic>P<\/jats:italic>\u2009=\u20099.49\u2009\u00d7\u200910<jats:sup>\u221213<\/jats:sup>), 13q34 (rs112998813,<jats:italic>P<\/jats:italic>\u2009=\u20094.58\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) and 16p13.13 (rs34972832<jats:italic>, P<\/jats:italic>\u2009=\u20092.12\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.<\/jats:p>","DOI":"10.1038\/s41467-017-00320-1","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T17:32:38Z","timestamp":1511803958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-0164","authenticated-orcid":false,"given":"Amit","family":"Sud","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-3116","authenticated-orcid":false,"given":"Hauke","family":"Thomsen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-4611","authenticated-orcid":false,"given":"Philip J.","family":"Law","sequence":"additional","affiliation":[]},{"given":"Asta","family":"F\u00f6rsti","sequence":"additional","affiliation":[]},{"given":"Miguel Inacio da 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