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Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337,<jats:italic>P<\/jats:italic>\u2009=\u20093.86\u2009\u00d7\u200910<jats:sup>\u22129<\/jats:sup>, odds ratio (OR)\u2009=\u20091.34) and for<jats:italic>ETV6-RUNX1<\/jats:italic>fusion-positive BCP-ALL at 2q22.3 (rs17481869,<jats:italic>P<\/jats:italic>\u2009=\u20093.20\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>, OR\u2009=\u20092.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.<\/jats:p>","DOI":"10.1038\/s41467-018-03178-z","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T02:42:04Z","timestamp":1522809724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia"],"prefix":"10.1038","volume":"9","author":[{"given":"Jayaram","family":"Vijayakrishnan","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7157-754X","authenticated-orcid":false,"given":"James","family":"Studd","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-5829","authenticated-orcid":false,"given":"Peter","family":"Broderick","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1783-6296","authenticated-orcid":false,"given":"Ben","family":"Kinnersley","sequence":"additional","affiliation":[]},{"given":"Amy","family":"Holroyd","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-4611","authenticated-orcid":false,"given":"Philip J.","family":"Law","sequence":"additional","affiliation":[]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[]},{"given":"James M.","family":"Allan","sequence":"additional","affiliation":[]},{"given":"Christine J.","family":"Harrison","sequence":"additional","affiliation":[]},{"given":"Anthony V.","family":"Moorman","sequence":"additional","affiliation":[]},{"given":"Ajay","family":"Vora","sequence":"additional","affiliation":[]},{"given":"Eve","family":"Roman","sequence":"additional","affiliation":[]},{"given":"Sivaramakrishna","family":"Rachakonda","sequence":"additional","affiliation":[]},{"given":"Sally E.","family":"Kinsey","sequence":"additional","affiliation":[]},{"given":"Eamonn","family":"Sheridan","sequence":"additional","affiliation":[]},{"given":"Pamela D.","family":"Thompson","sequence":"additional","affiliation":[]},{"given":"Julie A.","family":"Irving","sequence":"additional","affiliation":[]},{"given":"Rolf","family":"Koehler","sequence":"additional","affiliation":[]},{"given":"Per","family":"Hoffmann","sequence":"additional","affiliation":[]},{"given":"Markus M.","family":"N\u00f6then","sequence":"additional","affiliation":[]},{"given":"Stefanie","family":"Heilmann-Heimbach","sequence":"additional","affiliation":[]},{"given":"Karl-Heinz","family":"J\u00f6ckel","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2444-3247","authenticated-orcid":false,"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-732X","authenticated-orcid":false,"given":"Paul D. 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