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Here we show that\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    exposed to looming stimuli in a confined arena either freeze or flee. The probability of freezing versus fleeing is modulated by the fly\u2019s walking speed at the time of threat, demonstrating that freeze\/flee decisions depend on behavioral state. We describe a pair of descending neurons crucially implicated in freezing. Genetic silencing of DNp09 descending neurons disrupts freezing yet does not prevent fleeing. Optogenetic activation of both DNp09 neurons induces running and freezing in a state-dependent manner. Our findings establish walking speed as a key factor in defensive response choices and reveal a pair of descending neurons as a critical component in the circuitry mediating selection and execution of freezing or fleeing behaviors.\n                  <\/jats:p>","DOI":"10.1038\/s41467-018-05875-1","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T06:02:16Z","timestamp":1536213736000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Speed dependent descending control of freezing behavior in Drosophila melanogaster"],"prefix":"10.1038","volume":"9","author":[{"given":"Ricardo","family":"Zacarias","sequence":"first","affiliation":[]},{"given":"Shigehiro","family":"Namiki","sequence":"additional","affiliation":[]},{"given":"Gwyneth M.","family":"Card","sequence":"additional","affiliation":[]},{"given":"Maria Luisa","family":"Vasconcelos","sequence":"additional","affiliation":[]},{"given":"Marta A.","family":"Moita","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"5875_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.conb.2011.12.009","volume":"22","author":"GM Card","year":"2012","unstructured":"Card, G. 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