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Here, we have generated a unique set of fully human anti-\n                    <jats:italic>Candida<\/jats:italic>\n                    monoclonal antibodies (mAbs) with diagnostic and therapeutic potential by expressing recombinant antibodies from genes cloned from the B cells of patients suffering from candidiasis. Single class switched memory B cells isolated from donors serum-positive for anti-\n                    <jats:italic>Candida<\/jats:italic>\n                    IgG were differentiated in vitro and screened against recombinant\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    Hyr1 cell wall protein and whole fungal cell wall preparations. Antibody genes from\n                    <jats:italic>Candida<\/jats:italic>\n                    -reactive B cell cultures were cloned and expressed in Expi293F human embryonic kidney cells to generate a panel of human recombinant anti-\n                    <jats:italic>Candida<\/jats:italic>\n                    mAbs that demonstrate morphology-specific, high avidity binding to the cell wall. The species-specific and pan-\n                    <jats:italic>Candida<\/jats:italic>\n                    mAbs generated through this technology display favourable properties for diagnostics, strong opsono-phagocytic activity of macrophages in vitro, and protection in a murine model of disseminated candidiasis.\n                  <\/jats:p>","DOI":"10.1038\/s41467-018-07738-1","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T10:02:16Z","timestamp":1544004136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis"],"prefix":"10.1038","volume":"9","author":[{"given":"Fiona M.","family":"Rudkin","sequence":"first","affiliation":[]},{"given":"Ingrida","family":"Raziunaite","sequence":"additional","affiliation":[]},{"given":"Hillary","family":"Workman","sequence":"additional","affiliation":[]},{"given":"Sosthene","family":"Essono","sequence":"additional","affiliation":[]},{"given":"Rodrigo","family":"Belmonte","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-0378","authenticated-orcid":false,"given":"Donna M.","family":"MacCallum","sequence":"additional","affiliation":[]},{"given":"Elizabeth M.","family":"Johnson","sequence":"additional","affiliation":[]},{"given":"Lisete M.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Angelina S.","family":"Palma","sequence":"additional","affiliation":[]},{"given":"Ten","family":"Feizi","sequence":"additional","affiliation":[]},{"given":"Allan","family":"Jensen","sequence":"additional","affiliation":[]},{"given":"Lars P.","family":"Erwig","sequence":"additional","affiliation":[]},{"given":"Neil A. 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