{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:00:38Z","timestamp":1772629238570,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head\/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head\/neck cancer (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>g<\/jats:italic>\n                    <\/jats:sub>\n                    \u2009=\u20090.57,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20094.6\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    ), breast and ovarian cancer (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>g<\/jats:italic>\n                    <\/jats:sub>\n                    \u2009=\u20090.24,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20097\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ), breast and lung cancer (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>g<\/jats:italic>\n                    <\/jats:sub>\n                    \u2009=\u20090.18,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =1.5\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    ) and breast and colorectal cancer (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>g<\/jats:italic>\n                    <\/jats:sub>\n                    \u2009=\u20090.15,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.1\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    ). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.\n                  <\/jats:p>","DOI":"10.1038\/s41467-018-08054-4","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T06:02:48Z","timestamp":1548396168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Shared heritability and functional enrichment across six solid cancers"],"prefix":"10.1038","volume":"10","author":[{"given":"Xia","family":"Jiang","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-9828","authenticated-orcid":false,"given":"Hilary K.","family":"Finucane","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-7463","authenticated-orcid":false,"given":"Fredrick 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