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A variety of syndromic and non-syndromic neurodevelopmental disorders have been connected to alterations in metabotropic glutamate receptor (mGluR) signalling. These receptors contribute to synaptic plasticity, spine maturation and circuit development. Here, we investigate the physiological role of <jats:italic>Gprasp2<\/jats:italic>, a gene linked to neurodevelopmental disabilities and involved in the postendocytic sorting of G-protein-coupled receptors. We show that <jats:italic>Gprasp2<\/jats:italic> deletion leads to ASD-like behaviour in mice and alterations in synaptic communication. Manipulating the levels of <jats:italic>Gprasp2<\/jats:italic> bidirectionally modulates the surface availability of mGluR<jats:sub>5<\/jats:sub> and produces alterations in dendritic complexity, spine density and synaptic maturation. Loss of <jats:italic>Gprasp2<\/jats:italic> leads to enhanced hippocampal long-term depression, consistent with facilitated mGluR-dependent activation. These findings demonstrate a role for <jats:italic>Gprasp2<\/jats:italic> in glutamatergic synapses and suggest a possible mechanism by which this gene is linked to neurodevelopmental diseases.<\/jats:p>","DOI":"10.1038\/s41467-019-09382-9","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T11:03:19Z","timestamp":1553857399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-0607","authenticated-orcid":false,"given":"Mohamed","family":"Edfawy","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-1887","authenticated-orcid":false,"given":"Joana R.","family":"Guedes","sequence":"additional","affiliation":[]},{"given":"Marta I.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Mariana","family":"Laranjo","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio J.","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Xian","family":"Gao","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-0384","authenticated-orcid":false,"given":"Pedro A.","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Gladys","family":"Caldeira","sequence":"additional","affiliation":[]},{"given":"Lara O.","family":"Franco","sequence":"additional","affiliation":[]},{"given":"Dongqing","family":"Wang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-4561","authenticated-orcid":false,"given":"Ana Luisa","family":"Cardoso","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-277X","authenticated-orcid":false,"given":"Guoping","family":"Feng","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-6666","authenticated-orcid":false,"given":"Ana Luisa","family":"Carvalho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-2129","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Pe\u00e7a","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"9382_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nm.4071","volume":"22","author":"L de la Torre-Ubieta","year":"2016","unstructured":"de la Torre-Ubieta, L., Won, H., Stein, J. 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