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Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in\n                    <jats:italic>Drosophila melanogaster, Acetobacter pomorum<\/jats:italic>\n                    (\n                    <jats:italic>Ap<\/jats:italic>\n                    ) and\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    (\n                    <jats:italic>Lp<\/jats:italic>\n                    ) a syntrophic relationship\u00a0is established to overcome detrimental host diets and identify\n                    <jats:italic>Ap<\/jats:italic>\n                    as the bacterium altering the host\u2019s feeding decisions. Specifically, we show that\n                    <jats:italic>Ap<\/jats:italic>\n                    uses the lactate produced by\n                    <jats:italic>Lp<\/jats:italic>\n                    to supply amino acids that are essential to\n                    <jats:italic>Lp<\/jats:italic>\n                    , allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for\n                    <jats:italic>Ap<\/jats:italic>\n                    to alter the fly\u2019s protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets. These interactions also ensure the constant flow of metabolites used by the microbiome to alter reproduction and host behaviour.\n                  <\/jats:p>","DOI":"10.1038\/s41467-020-18049-9","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T06:04:04Z","timestamp":1598335444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-1573","authenticated-orcid":false,"given":"S\u00edlvia F.","family":"Henriques","sequence":"first","affiliation":[]},{"given":"Darshan B.","family":"Dhakan","sequence":"additional","affiliation":[]},{"given":"L\u00facia","family":"Serra","sequence":"additional","affiliation":[]},{"given":"Ana Patr\u00edcia","family":"Francisco","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-308X","authenticated-orcid":false,"given":"Zita","family":"Carvalho-Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-9749","authenticated-orcid":false,"given":"C\u00e9lia","family":"Baltazar","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-4814","authenticated-orcid":false,"given":"Ana Paula","family":"Elias","sequence":"additional","affiliation":[]},{"given":"Margarida","family":"Anjos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6900-1886","authenticated-orcid":false,"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-9091","authenticated-orcid":false,"given":"Oliver D. 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