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Therefore, co-optimizing interdependent systems is necessary to understand the impact of one sector on another. We propose a framework to identify the optimal investment mix for a co-optimized water-power system and apply it to Neom, Saudi Arabia. Our results show that investment strategies that consider the co-optimization of both systems result in total cost savings for the power sector compared to independent approaches. Analysis results suggest that systems with higher shares of non-dispatchable renewables experience the most significant cost reductions.<\/jats:p>","DOI":"10.1038\/s41467-022-31233-3","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T11:02:45Z","timestamp":1655550165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Simulated co-optimization of renewable energy and desalination systems in Neom, Saudi Arabia"],"prefix":"10.1038","volume":"13","author":[{"given":"Jefferson A.","family":"Riera","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-6089","authenticated-orcid":false,"given":"Ricardo M.","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Ibrahim","family":"Hoteit","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-1112","authenticated-orcid":false,"given":"Omar","family":"Knio","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"31233_CR1","unstructured":"IRENA. 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