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The genetic factors contributing to susceptibility across different populations and tumour subsites remain incompletely understood. Here we show, through a genome-wide association and fine mapping study of over 19,000 HNSCC cases and 38,000 controls from multiple ancestries, 18 genetic risk variants and 11 signals from fine mapping of the human leukocyte antigen (HLA) region, all previously unreported. rs78378222, a regulatory variant for <jats:italic>TP53<\/jats:italic> is associated with a 40% reduction in overall HNSCC risk. We also identify gene-environment interactions, with <jats:italic>BRCA2<\/jats:italic> and <jats:italic>ADH1B<\/jats:italic> variants showing effects modified by smoking and alcohol use. Subsite-specific analysis of the HLA region reveals distinct immune-related associations across HPV-positive and HPV-negative tumours. These findings refine the genetic architecture of HNSCC and highlight mechanisms linking inherited variation, immunity, and environmental exposures.<\/jats:p>","DOI":"10.1038\/s41467-025-63842-z","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T09:09:51Z","timestamp":1759396191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-3447","authenticated-orcid":false,"given":"Elmira","family":"Ebrahimi","sequence":"first","affiliation":[]},{"given":"Apiwat","family":"Sangphukieo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-3729","authenticated-orcid":false,"given":"Hanla 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