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Inspired by concepts of selective kinetic regulation found in Maxwell\u2019s demon-like systems, we explore hydrogen bonding as a molecular-level selector for modulating the thermal back-conversion of quadricyclane (QC) to norbornadiene (NBD). By strategically incorporating hydrogen-bond donors and acceptors, we show that these interactions build a water \u201cbridge\u201d that restricts rotational degrees of freedom. This bridge significantly elevates the kinetic barrier and redirects the isomerization along an alternative reaction coordinate. In this manner, the hydrogen-bonding system selectively regulates the thermal back-conversion dynamics and enables directional control over the isomerization kinetics, achieving up to a 5000-fold extension of the thermal half-life. 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