{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:38:58Z","timestamp":1776346738736,"version":"3.51.2"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature Plants"],"DOI":"10.1038\/s41477-018-0216-8","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T17:28:24Z","timestamp":1533058104000},"page":"699-710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Individual components of paired typical NLR immune receptors are regulated by distinct E3 ligases"],"prefix":"10.1038","volume":"4","author":[{"given":"Oliver Xiaoou","family":"Dong","sequence":"first","affiliation":[]},{"given":"Kevin","family":"Ao","sequence":"additional","affiliation":[]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Kaeli C. M.","family":"Johnson","sequence":"additional","affiliation":[]},{"given":"Yuxiang","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[]},{"given":"Shitou","family":"Xia","sequence":"additional","affiliation":[]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Eleazar","family":"Rodriguez","sequence":"additional","affiliation":[]},{"given":"Xuejin","family":"Chen","sequence":"additional","affiliation":[]},{"given":"She","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Yuelin","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Morten","family":"Petersen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6354-2021","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"216_CR1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.cell.2006.02.008","volume":"124","author":"ST Chisholm","year":"2006","unstructured":"Chisholm, S. T., Coaker, G., Day, B. & Staskawicz, B. J. Host\u2013microbe interactions: shaping the evolution of the plant immune response. Cell 124, 803\u2013814 (2006).","journal-title":"Cell"},{"key":"216_CR2","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1126\/science.1236011","volume":"341","author":"JL Dangl","year":"2013","unstructured":"Dangl, J. L., Horvath, D. M. & Staskawicz, B. J. Pivoting the plant immune system from dissection to deployment. Science 341, 746\u2013751 (2013).","journal-title":"Science"},{"key":"216_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.molcel.2014.03.028","volume":"54","author":"AP Macho","year":"2014","unstructured":"Macho, A. P. & Zipfel, C. Plant PRRs and the activation of innate immune signaling. Mol. Cell 54, 263\u2013272 (2014).","journal-title":"Mol. Cell"},{"key":"216_CR4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.mib.2008.12.003","volume":"12","author":"S Cunnac","year":"2009","unstructured":"Cunnac, S., Lindeberg, M. & Collmer, A. Pseudomonas syringae type III secretion system effectors: repertoires in search of functions. Curr. Opin. Microbiol. 12, 53\u201360 (2009).","journal-title":"Curr. Opin. Microbiol."},{"key":"216_CR5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/ni.2083","volume":"12","author":"T Maekawa","year":"2011","unstructured":"Maekawa, T., Kufer, T. A. & Schulze-Lefert, P. NLR functions in plant and animal immune systems: so far and yet so close. Nat. Immunol. 12, 817\u2013826 (2011).","journal-title":"Nat. Immunol."},{"key":"216_CR6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.coi.2015.01.014","volume":"32","author":"X Li","year":"2015","unstructured":"Li, X., Kapos, P. & Zhang, Y. NLRs in plants. Curr. Opin. Immunol. 32, 114\u2013121 (2015).","journal-title":"Curr. Opin. Immunol."},{"key":"216_CR7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ni.1703","volume":"10","author":"L Franchi","year":"2009","unstructured":"Franchi, L., Eigenbrod, T., Munoz-Planillo, R. & Nunez, G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 10, 241\u2013247 (2009).","journal-title":"Nat. Immunol."},{"key":"216_CR8","first-page":"827","volume":"119","author":"A Bentham","year":"2017","unstructured":"Bentham, A., Burdett, H., Anderson, P. A., Williams, S. J. & Kobe, B. Animal NLRs provide structural insights into plant NLR function. Ann. Bot. 119, 827\u2013702 (2017).","journal-title":"Ann. Bot."},{"key":"216_CR9","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.it.2014.09.005","volume":"35","author":"T Griebel","year":"2014","unstructured":"Griebel, T., Maekawa, T. & Parker, J. E. NOD-like receptor cooperativity in effector-triggered immunity. Trends Immunol. 35, 562\u2013570 (2014).","journal-title":"Trends Immunol."},{"key":"216_CR10","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/nph.13869","volume":"210","author":"T Kroj","year":"2016","unstructured":"Kroj, T., Chanclud, E., Michel-Romiti, C., Grand, X. & Morel, J. B. Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread. New Phytol. 210, 618\u2013626 (2016).","journal-title":"New Phytol."},{"key":"216_CR11","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.cell.2015.04.024","volume":"161","author":"PF Sarris","year":"2015","unstructured":"Sarris, P. F. et al. A plant immune receptor detects pathogen effectors that target WRKY transcription factors. Cell 161, 1089\u20131100 (2015).","journal-title":"Cell"},{"key":"216_CR12","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.cell.2015.04.025","volume":"161","author":"C Le Roux","year":"2015","unstructured":"Le Roux, C. et al. A receptor pair with an integrated decoy converts pathogen disabling of transcription factors to immunity. Cell 161, 1074\u20131088 (2015).","journal-title":"Cell"},{"key":"216_CR13","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1126\/science.1247357","volume":"344","author":"SJ Williams","year":"2014","unstructured":"Williams, S. J. et al. Structural basis for assembly and function of a heterodimeric plant immune receptor. Science 344, 299\u2013303 (2014).","journal-title":"Science"},{"key":"216_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7338","volume":"6","author":"SB Saucet","year":"2015","unstructured":"Saucet, S. B. et al. Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4. Nat. Commun. 6, 6338 (2015).","journal-title":"Nat. Commun."},{"key":"216_CR15","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1105\/tpc.112.107201","volume":"25","author":"S Cesari","year":"2013","unstructured":"Cesari, S. et al. The rice resistance protein pair RGA4\/RGA5 recognizes the Magnaporthe oryzae effectors AVR-Pia and AVR1-CO39 by direct binding. Plant Cell. 25, 1463\u20131481 (2013).","journal-title":"Plant Cell."},{"key":"216_CR16","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.15252\/embj.201487923","volume":"33","author":"S Cesari","year":"2014","unstructured":"Cesari, S. et al. The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance. EMBO J. 33, 1941\u20131959 (2014).","journal-title":"EMBO J."},{"key":"216_CR17","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1094\/MPMI.2001.14.10.1131","volume":"14","author":"X Li","year":"2001","unstructured":"Li, X., Clarke, J. D., Zhang, Y. & Dong, X. Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance. Mol. Plant Microbe Interact. 14, 1131\u20131139 (2001).","journal-title":"Mol. Plant Microbe Interact."},{"key":"216_CR18","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1105\/tpc.015842","volume":"15","author":"Y Zhang","year":"2003","unstructured":"Zhang, Y., Goritschnig, S., Dong, X. & Li, X. A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in suppressor of npr1-1, constitutive 1. Plant Cell. 15, 2636\u20132646 (2003).","journal-title":"Plant Cell."},{"key":"216_CR19","doi-asserted-by":"publisher","first-page":"14694","DOI":"10.1073\/pnas.1105685108","volume":"108","author":"YT Cheng","year":"2011","unstructured":"Cheng, Y. T. et al. Stability of plant immune-receptor resistance proteins is controlled by SKP1\u2013CULLIN1\u2013F-box (SCF)-mediated protein degradation. Proc. Natl Acad. Sci. USA 108, 14694\u201314699 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"216_CR20","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1365-313X.2011.04799.x","volume":"69","author":"M Gou","year":"2012","unstructured":"Gou, M. et al. The F-box protein CPR1\/CPR30 negatively regulates R protein SNC1 accumulation. Plant J. 69, 411\u2013420 (2012).","journal-title":"Plant J."},{"key":"216_CR21","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.tplants.2011.09.001","volume":"16","author":"R Alcazar","year":"2011","unstructured":"Alcazar, R. & Parker, J. E. The impact of temperature on balancing immune responsiveness and growth in Arabidopsis. Trends Plant Sci. 16, 666\u2013675 (2011).","journal-title":"Trends Plant Sci."},{"key":"216_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1101\/sqb.2013.77.014738","volume":"77","author":"KC Johnson","year":"2012","unstructured":"Johnson, K. C., Dong, O. X., Huang, Y. & Li, X. A rolling stone gathers no moss, but resistant plants must gather their moses. Cold Spring Harb. Symp. Quant. Biol. 77, 259\u2013268 (2012).","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"216_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3558","volume":"4","author":"Y Huang","year":"2013","unstructured":"Huang, Y. et al. Mitochondrial AtPAM16 is required for plant survival and the negative regulation of plant immunity. Nat. Commun. 4, 2558 (2013).","journal-title":"Nat. Commun."},{"key":"216_CR24","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.pbi.2012.03.014","volume":"15","author":"YT Cheng","year":"2012","unstructured":"Cheng, Y. T. & Li, X. Ubiquitination in NB-LRR-mediated immunity. Curr. Opin. Plant Biol. 15, 392\u2013399 (2012).","journal-title":"Curr. Opin. Plant Biol."},{"key":"216_CR25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1146\/annurev.biochem.70.1.503","volume":"70","author":"CM Pickart","year":"2001","unstructured":"Pickart, C. M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503\u2013533 (2001).","journal-title":"Annu. Rev. Biochem."},{"key":"216_CR26","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1146\/annurev.arplant.55.031903.141801","volume":"55","author":"J Smalle","year":"2004","unstructured":"Smalle, J. & Vierstra, R. D. The ubiquitin 26S proteasome proteolytic pathway. Annu. Rev. Plant Biol. 55, 555\u2013590 (2004).","journal-title":"Annu. Rev. Plant Biol."},{"key":"216_CR27","doi-asserted-by":"publisher","first-page":"e1003465","DOI":"10.1371\/journal.pgen.1003465","volume":"9","author":"M Roberts","year":"2013","unstructured":"Roberts, M., Tang, S., Stallmann, A., Dangl, J. L. & Bonardi, V. Genetic requirements for signaling from an autoactive plant NB-LRR intracellular innate immune receptor. PLoS Genet. 9, e1003465 (2013).","journal-title":"PLoS Genet."},{"key":"216_CR28","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.chom.2017.03.005","volume":"21","author":"S Lolle","year":"2017","unstructured":"Lolle, S. et al. Matching NLR immune receptors to autoimmunity in camta3 mutants using antimorphic NLR alleles. Cell Host Microbe 21, 518\u2013529.e4 (2017).","journal-title":"Cell Host Microbe"},{"key":"216_CR29","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1105\/tpc.11.11.2099","volume":"11","author":"L Noel","year":"1999","unstructured":"Noel, L. et al. Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis. Plant Cell. 11, 2099\u20132112 (1999).","journal-title":"Plant Cell."},{"key":"216_CR30","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1105\/tpc.020479","volume":"16","author":"S Yang","year":"2004","unstructured":"Yang, S. & Hua, J. A haplotype-specific Resistance gene regulated by BONZAI1 mediates temperature-dependent growth control in Arabidopsis. Plant Cell. 16, 1060\u20131071 (2004).","journal-title":"Plant Cell."},{"key":"216_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0715-0","volume":"16","author":"ZP Wang","year":"2015","unstructured":"Wang, Z. P. et al. Egg cell-specific promoter-controlled CRISPR\/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation. Genome Biol. 16, 144 (2015).","journal-title":"Genome Biol."},{"key":"216_CR32","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1105\/tpc.15.00173","volume":"27","author":"F Xu","year":"2015","unstructured":"Xu, F. et al. Two N-terminal acetyltransferases antagonistically regulate the stability of a NOD-like receptor in Arabidopsis. Plant Cell. 27, 1547\u20131562 (2015).","journal-title":"Plant Cell."},{"key":"216_CR33","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1093\/mp\/ssu097","volume":"7","author":"F Xu","year":"2014","unstructured":"Xu, F., Cheng, Y. T., Kapos, P., Huang, Y. & Li, X. P-loop-dependent NLR SNC1 can oligomerize and activate immunity in the nucleus. Mol. Plant 7, 1801\u20131804 (2014).","journal-title":"Mol. Plant"},{"key":"216_CR34","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1101\/gad.1559607","volume":"21","author":"K Palma","year":"2007","unstructured":"Palma, K. et al. Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms. Genes Dev. 21, 1484\u20131493 (2007).","journal-title":"Genes Dev."},{"key":"216_CR35","doi-asserted-by":"publisher","first-page":"10171","DOI":"10.1073\/pnas.0900604106","volume":"106","author":"S Kosugi","year":"2009","unstructured":"Kosugi, S., Hasebe, M., Tomita, M. & Yanagawa, H. Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc. Natl Acad. Sci. USA 106, 10171\u201310176 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"216_CR36","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/tpj.12127","volume":"74","author":"Q Zhao","year":"2013","unstructured":"Zhao, Q. et al. A plant-specific in vitro ubiquitination analysis system. Plant J. 74, 524\u2013533 (2013).","journal-title":"Plant J."},{"key":"216_CR37","doi-asserted-by":"publisher","first-page":"8281","DOI":"10.1073\/pnas.0602874103","volume":"103","author":"CH Dong","year":"2006","unstructured":"Dong, C. H., Agarwal, M., Zhang, Y., Xie, Q. & Zhu, J. K. The negative regulator of plant cold responses, HOS1, is a RING E3 ligase that mediates the ubiquitination and degradation of ICE1. Proc. Natl Acad. Sci. USA 103, 8281\u20138286 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"216_CR38","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1105\/tpc.106.048488","volume":"19","author":"Y Zhang","year":"2007","unstructured":"Zhang, Y. et al. SDIR1 is a RING finger E3 ligase that positively regulates stress-responsive abscisic acid signaling in Arabidopsis. Plant Cell. 19, 1912\u20131929 (2007).","journal-title":"Plant Cell."},{"key":"216_CR39","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/tpj.12122","volume":"74","author":"YJ Peng","year":"2013","unstructured":"Peng, Y. J. et al. A RING-type E3 ligase controls anther dehiscence by activating the jasmonate biosynthetic pathway gene DEFECTIVE IN ANTHER DEHISCENCE1 in Arabidopsis. Plant J. 74, 310\u2013327 (2013).","journal-title":"Plant J."},{"key":"216_CR40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nature00998","volume":"419","author":"Q Xie","year":"2002","unstructured":"Xie, Q. et al. SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature 419, 167\u2013170 (2002).","journal-title":"Nature"},{"key":"216_CR41","doi-asserted-by":"publisher","first-page":"10306","DOI":"10.1073\/pnas.95.17.10306","volume":"95","author":"N Aarts","year":"1998","unstructured":"Aarts, N. et al. Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. Proc. Natl Acad. Sci. USA 95, 10306\u201310311 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"216_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.chom.2012.01.015","volume":"11","author":"Z Zhang","year":"2012","unstructured":"Zhang, Z. et al. Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. Cell Host Microbe 11, 253\u2013263 (2012).","journal-title":"Cell Host Microbe"},{"key":"216_CR43","doi-asserted-by":"publisher","first-page":"e1004312","DOI":"10.1371\/journal.ppat.1004312","volume":"10","author":"F Xu","year":"2014","unstructured":"Xu, F. et al. NLR-associating transcription factor bHLH84 and its paralogs function redundantly in plant immunity. PLoS Pathog. 10, e1004312 (2014).","journal-title":"PLoS Pathog."},{"key":"216_CR44","doi-asserted-by":"publisher","first-page":"13960","DOI":"10.1073\/pnas.1002828107","volume":"107","author":"Z Zhu","year":"2010","unstructured":"Zhu, Z. et al. Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor. Proc. Natl Acad. Sci. USA 107, 13960\u201313965 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"216_CR45","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/j.1365-313X.2004.02099.x","volume":"38","author":"E Sinapidou","year":"2004","unstructured":"Sinapidou, E. et al. Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in Arabidopsis. Plant J. 38, 898\u2013909 (2004).","journal-title":"Plant J."},{"key":"216_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/srep08792","volume":"5","author":"F Xu","year":"2015","unstructured":"Xu, F. et al. Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour. Sci. Rep. 5, 8792 (2015).","journal-title":"Sci. Rep."},{"key":"216_CR47","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1534\/genetics.108.099226","volume":"181","author":"SK Lee","year":"2009","unstructured":"Lee, S. K. et al. Rice Pi5-mediated resistance to Magnaporthe oryzae requires the presence of two coiled-coil-nucleotide-binding-leucine-rich repeat genes. Genetics 181, 1627\u20131638 (2009).","journal-title":"Genetics"},{"key":"216_CR48","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1469-8137.2010.03462.x","volume":"189","author":"C Zhai","year":"2011","unstructured":"Zhai, C. et al. The isolation and characterization of Pik, a rice blast resistance gene which emerged after rice domestication. New Phytol. 189, 321\u2013334 (2011).","journal-title":"New Phytol."},{"key":"216_CR49","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1111\/j.1365-313X.2009.04024.x","volume":"60","author":"C Loutre","year":"2009","unstructured":"Loutre, C. et al. Two different CC-NBS-LRR genes are required for Lr10-mediated leaf rust resistance in tetraploid and hexaploid wheat. Plant J. 60, 1043\u20131054 (2009).","journal-title":"Plant J."},{"key":"216_CR50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/mp\/sss121","volume":"6","author":"Y Brotman","year":"2013","unstructured":"Brotman, Y. et al. Dual resistance of melon to Fusarium oxysporum races 0 and 2 and to Papaya ring-spot virus is controlled by a pair of head-to-head-oriented NB-LRR genes of unusual architecture. Mol. Plant 6, 235\u2013238 (2013).","journal-title":"Mol. Plant"},{"key":"216_CR51","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/j.1365-313X.2005.02500.x","volume":"43","author":"Y Noutoshi","year":"2005","unstructured":"Noutoshi, Y. et al. A single amino acid insertion in the WRKY domain of the Arabidopsis TIR-NBS-LRR-WRKY-type disease resistance protein SLH1 (sensitive to low humidity 1) causes activation of defense responses and hypersensitive cell death. Plant J. 43, 873\u2013888 (2005).","journal-title":"Plant J."},{"key":"216_CR52","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1365-313X.2010.04241.x","volume":"63","author":"H Yang","year":"2010","unstructured":"Yang, H. et al. A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell death and freezing tolerance in a temperature-dependent manner in Arabidopsis. Plant J. 63, 283\u2013296 (2010).","journal-title":"Plant J."},{"key":"216_CR53","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","volume":"16","author":"SJ Clough","year":"1998","unstructured":"Clough, S. J. & Bent, A. F. Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J. 16, 735\u2013743 (1998).","journal-title":"Plant J."},{"key":"216_CR54","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/mp\/ssu009","volume":"7","author":"K Xie","year":"2014","unstructured":"Xie, K., Zhang, J. & Yang, Y. Genome-wide prediction of highly specific guide RNA spacers for CRISPR\u2013Cas9-mediated genome editing in model plants and major crops. Mol. Plant 7, 923\u2013926 (2014).","journal-title":"Mol. Plant"},{"key":"216_CR55","first-page":"69","volume":"354","author":"Y Zhang","year":"2007","unstructured":"Zhang, Y., Glazebrook, J. & Li, X. Identification of components in disease-resistance signaling in Arabidopsis by map-based cloning. Methods Mol. Biol. 354, 69\u201378 (2007).","journal-title":"Methods Mol. Biol."},{"key":"216_CR56","doi-asserted-by":"publisher","first-page":"e718","DOI":"10.1371\/journal.pone.0000718","volume":"2","author":"D Winter","year":"2007","unstructured":"Winter, D. et al. An \u201cElectronic Fluorescent Pictograph\u201d browser for exploring and analyzing large-scale biological data sets. PLoS ONE 2, e718 (2007).","journal-title":"PLoS ONE"},{"key":"216_CR57","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/ng1543","volume":"37","author":"M Schmid","year":"2005","unstructured":"Schmid, M. et al. A gene expression map of Arabidopsis thaliana development. Nat. Genet. 37, 501\u2013506 (2005).","journal-title":"Nat. Genet."},{"key":"216_CR58","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1105\/tpc.113.119057","volume":"26","author":"Y Huang","year":"2014","unstructured":"Huang, Y. et al. An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis. Plant Cell. 26, 485\u2013496 (2014).","journal-title":"Plant Cell."},{"key":"216_CR59","doi-asserted-by":"publisher","first-page":"e1001111","DOI":"10.1371\/journal.ppat.1001111","volume":"6","author":"Y Li","year":"2010","unstructured":"Li, Y. et al. SRFR1 negatively regulates plant NB-LRR resistance protein accumulation to prevent autoimmunity. PLoS Pathog. 6, e1001111 (2010).","journal-title":"PLoS Pathog."},{"key":"216_CR60","doi-asserted-by":"publisher","first-page":"D974","DOI":"10.1093\/nar\/gku986","volume":"43","author":"S Proost","year":"2015","unstructured":"Proost, S. et al. PLAZA 3.0: an access point for plant comparative genomics. Nucleic Acids Res. 43, D974\u2013D981 (2015).","journal-title":"Nucleic Acids Res."},{"key":"216_CR61","doi-asserted-by":"publisher","first-page":"D1178","DOI":"10.1093\/nar\/gkr944","volume":"40","author":"DM Goodstein","year":"2012","unstructured":"Goodstein, D. M. et al. Phytozome: a comparative platform for green plant genomics. Nucleic Acids Res. 40, D1178\u2013D1186 (2012).","journal-title":"Nucleic Acids Res."},{"key":"216_CR62","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"RC Edgar","year":"2004","unstructured":"Edgar, R. C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32, 1792\u20131797 (2004).","journal-title":"Nucleic Acids Res."},{"key":"216_CR63","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","volume":"30","author":"A Stamatakis","year":"2014","unstructured":"Stamatakis, A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30, 1312\u20131313 (2014).","journal-title":"Bioinformatics"},{"key":"216_CR64","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","volume":"21","author":"F Abascal","year":"2005","unstructured":"Abascal, F., Zardoya, R. & Posada, D. ProtTest: selection of best-fit models of protein evolution. Bioinformatics 21, 2104\u20132105 (2005).","journal-title":"Bioinformatics"}],"container-title":["Nature Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41477-018-0216-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41477-018-0216-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41477-018-0216-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T22:05:42Z","timestamp":1671573942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41477-018-0216-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":64,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["216"],"URL":"https:\/\/doi.org\/10.1038\/s41477-018-0216-8","relation":{},"ISSN":["2055-0278"],"issn-type":[{"value":"2055-0278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]},"assertion":[{"value":"9 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}