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This study identifies a novel candidate rare locus for LDL-C, adding insights into the genetic architecture of a complex trait implicated in cardiovascular disease.<\/jats:p>","DOI":"10.1038\/s41525-024-00417-9","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T12:05:42Z","timestamp":1719576342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare variants at KCNJ2 are associated with LDL-cholesterol levels in a cross-population study"],"prefix":"10.1038","volume":"9","author":[{"given":"Niccol\u00f2","family":"Rossi","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-5237","authenticated-orcid":false,"given":"Najeeb","family":"Syed","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-2019","authenticated-orcid":false,"given":"Alessia","family":"Visconti","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-1854","authenticated-orcid":false,"given":"Elbay","family":"Aliyev","sequence":"additional","affiliation":[]},{"given":"Sarah","family":"Berry","sequence":"additional","affiliation":[]},{"given":"Mafalda","family":"Bourbon","sequence":"additional","affiliation":[]},{"given":"Tim D.","family":"Spector","sequence":"additional","affiliation":[]},{"given":"Pirro G.","family":"Hysi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-1276","authenticated-orcid":false,"given":"Khalid A.","family":"Fakhro","sequence":"additional","affiliation":[]},{"given":"Mario","family":"Falchi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"417_CR1","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ng.2797","volume":"45","author":"CJ Willer","year":"2013","unstructured":"Willer, C. 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