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Since the inception of the first such algorithm, the Adaptive Derivative-Assembled Problem-Tailored Variational Quantum Eigensolver (ADAPT-VQE), many improvements have appeared in the literature. We combine the key improvements along with a novel operator pool\u2014which we term Coupled Exchange Operator (CEO) pool\u2014to assess the cost of running state-of-the-art ADAPT-VQE on hardware in terms of measurement counts and circuit depth. We show a dramatic reduction of these quantum computational resources compared to the early versions of the algorithm: CNOT count, CNOT depth and measurement costs are reduced by up to 88%, 96% and 99.6%, respectively, for molecules represented by 12 to 14 qubits (LiH, H<jats:sub>6<\/jats:sub> and BeH<jats:sub>2<\/jats:sub>). We also find that our state-of-the-art CEO-ADAPT-VQE outperforms the Unitary Coupled Cluster Singles and Doubles ansatz, the most widely used static VQE ansatz, in all relevant metrics, and offers a five order of magnitude decrease in measurement costs as compared to other static ans\u00e4tze with competitive CNOT counts.<\/jats:p>","DOI":"10.1038\/s41534-025-01039-4","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T12:27:47Z","timestamp":1748262467000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Reducing the resources required by ADAPT-VQE using coupled exchange operators and improved subroutines"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-7801","authenticated-orcid":false,"given":"Mafalda","family":"Ram\u00f4a","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-1791","authenticated-orcid":false,"given":"Panagiotis G.","family":"Anastasiou","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-1129","authenticated-orcid":false,"given":"Luis Paulo","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-9781","authenticated-orcid":false,"given":"Nicholas J.","family":"Mayhall","sequence":"additional","affiliation":[]},{"given":"Edwin","family":"Barnes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-5589","authenticated-orcid":false,"given":"Sophia E.","family":"Economou","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"1039_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/BF02650179","volume":"21","author":"RP Feynman","year":"1982","unstructured":"Feynman, R. 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