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As a result of their merger, predicted in around 5 billion years, the two large spiral galaxies that define the present Local Group would form a new elliptical galaxy. Here we consider the latest and most accurate observations by the Gaia and Hubble space telescopes, along with recent consensus mass estimates, to derive possible future scenarios and identify the main sources of uncertainty in the evolution of the Local Group over the next 10 billion years. We found that the next most massive Local Group member galaxies\u2014namely, M33 and the Large Magellanic Cloud\u2014distinctly and radically affect the Milky Way\u2013Andromeda orbit. Although including M33 increases the merger probability, the orbit of the Large Magellanic Cloud runs perpendicular to the Milky Way\u2013Andromeda orbit and makes their merger less probable. In the full system, we found that uncertainties in the present positions, motions and masses of all galaxies leave room for drastically different outcomes and a probability of close to 50% that there will be no Milky Way\u2013Andromeda merger during the next 10 billion years. Based on the best available data, the fate of our Galaxy is still completely open.<\/jats:p>","DOI":"10.1038\/s41550-025-02563-1","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:02:07Z","timestamp":1748862127000},"page":"1206-1217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["No certainty of a Milky Way\u2013Andromeda collision"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2403-5358","authenticated-orcid":false,"given":"Till","family":"Sawala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehanne","family":"Delhomelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6146-2645","authenticated-orcid":false,"given":"Alis J.","family":"Deason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-716X","authenticated-orcid":false,"given":"Carlos S.","family":"Frenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3652-6878","authenticated-orcid":false,"given":"Jenni","family":"H\u00e4kkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-8263","authenticated-orcid":false,"given":"Peter H.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-2977","authenticated-orcid":false,"given":"Atte","family":"Keitaanranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rawlings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1367-0949","authenticated-orcid":false,"given":"Ruby","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"2563_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1088\/0004-6256\/144\/1\/4","volume":"144","author":"AW McConnachie","year":"2012","unstructured":"McConnachie, A. 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