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J.C.G. and D.D.S. are employees of F. Hoffmann\u2013La Roche. S.B. is an employee of Novartis. A.Z. received honoraria from Bristol-Myers Squibb, Merck Sharp & Dohme, Hoffmann\u2013La Roche, NBE Therapeutics, Secarna, ACM Pharma and Hookipa. A.Z. maintains non-commercial research agreements with Hoffmann\u2013La Roche. A.Z. maintains further non-commercial research agreements with NBE Therapeutics, Secarna, ACM Pharma, Hookipa and BeyondSpring. M.B.-A. owns equities in and receives laboratory support and compensation from Novartis, and serves as consultant for Basilea. Outside of the submitted work, W.P.W. received research support from Takeda Pharmaceuticals International paid to the Swiss Group for Clinical Cancer Research (SAKK) and personal honoraria from Genomic Health. Support for meetings was paid to his institution from Sandoz, Genomic Health, Medtronic, Novartis Oncology, Pfizer and Eli Lilly.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}