{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:51:12Z","timestamp":1787824272569,"version":"build-2784847793"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"8112","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2026,4,30]]},"DOI":"10.1038\/s41586-026-10169-4","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:02:51Z","timestamp":1772035371000},"page":"1264-1273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Human hippocampal neurogenesis in adulthood, ageing and Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"652","author":[{"given":"Ahmed","family":"Disouky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-4680","authenticated-orcid":false,"given":"Mark A.","family":"Sanborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-6694","authenticated-orcid":false,"given":"K. R.","family":"Sabitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa M.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Alejandro","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisha","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-8554","authenticated-orcid":false,"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-1469","authenticated-orcid":false,"given":"C. Dirk","family":"Keene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Gefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-Marsel","family":"Mesulam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changiz","family":"Geula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-6788","authenticated-orcid":false,"given":"Mark","family":"Maienschein-Cline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-9292","authenticated-orcid":false,"given":"Jalees","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-948X","authenticated-orcid":false,"given":"Orly","family":"Lazarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"10169_CR1","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1523\/JNEUROSCI.0676-20.2020","volume":"41","author":"SF Sorrells","year":"2021","unstructured":"Sorrells, S. F. et al. Positive controls in adults and children support that very few, if any, new neurons are born in the adult human hippocampus. J. Neurosci. 41, 2554\u20132565 (2021).","journal-title":"J. Neurosci."},{"key":"10169_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nature25975","volume":"555","author":"SF Sorrells","year":"2018","unstructured":"Sorrells, S. F. et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature 555, 377\u2013381 (2018).","journal-title":"Nature"},{"key":"10169_CR3","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.stem.2018.11.006","volume":"23","author":"MF Paredes","year":"2018","unstructured":"Paredes, M. F. et al. Does adult neurogenesis persist in the human hippocampus?\u00a0Cell Stem Cell 23, 780\u2013781 (2018).","journal-title":"Cell Stem Cell"},{"key":"10169_CR4","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.stem.2019.05.003","volume":"24","author":"MK Tobin","year":"2019","unstructured":"Tobin, M. K. et al. Human hippocampal neurogenesis persists in aged adults and Alzheimer\u2019s disease patients. Cell Stem Cell 24, 974\u2013982 (2019).","journal-title":"Cell Stem Cell"},{"key":"10169_CR5","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","volume":"25","author":"EP Moreno-Jimenez","year":"2019","unstructured":"Moreno-Jimenez, E. P. et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease. Nat. Med. 25, 554\u2013560 (2019).","journal-title":"Nat. Med."},{"key":"10169_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/hipo.23474","volume":"33","author":"J Terreros-Roncal","year":"2023","unstructured":"Terreros-Roncal, J. et al. Methods to study adult hippocampal neurogenesis in humans and across the phylogeny. Hippocampus 33, 271\u2013306 (2023).","journal-title":"Hippocampus"},{"key":"10169_CR7","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/s42003-023-05367-z","volume":"6","author":"M Gallardo-Caballero","year":"2023","unstructured":"Gallardo-Caballero, M. et al. Prolonged fixation and post-mortem delay impede the study of adult neurogenesis in mice. Commun. Biol. 6, 978 (2023).","journal-title":"Commun. Biol."},{"key":"10169_CR8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41596-019-0267-y","volume":"15","author":"M Flor-Garcia","year":"2020","unstructured":"Flor-Garcia, M. et al. Unraveling human adult hippocampal neurogenesis. Nat. Protoc. 15, 668\u2013693 (2020).","journal-title":"Nat. Protoc."},{"key":"10169_CR9","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.stem.2018.03.015","volume":"22","author":"M Boldrini","year":"2018","unstructured":"Boldrini, M. et al. Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 22, 589\u2013599 (2018).","journal-title":"Cell Stem Cell"},{"key":"10169_CR10","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.stem.2018.10.025","volume":"23","author":"AN Tartt","year":"2018","unstructured":"Tartt, A. N. et al. Considerations for assessing the extent of hippocampal neurogenesis in the adult and aging human brain. Cell Stem Cell 23, 782\u2013783 (2018).","journal-title":"Cell Stem Cell"},{"key":"10169_CR11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41586-022-04912-w","volume":"607","author":"Y Zhou","year":"2022","unstructured":"Zhou, Y. et al. Molecular landscapes of human hippocampal immature neurons across lifespan. Nature 607, 527\u2013533 (2022).","journal-title":"Nature"},{"key":"10169_CR12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.neuron.2021.10.036","volume":"110","author":"D Franjic","year":"2022","unstructured":"Franjic, D. et al. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron 110, 452\u2013469 (2022).","journal-title":"Neuron"},{"key":"10169_CR13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.adu9575","volume":"389","author":"I Dumitru","year":"2025","unstructured":"Dumitru, I. et al. Identification of proliferating neural progenitors in the adult human hippocampus. Science 389, 58\u201363 (2025).","journal-title":"Science"},{"key":"10169_CR14","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1017\/S1355617712000847","volume":"18","author":"TM Harrison","year":"2012","unstructured":"Harrison, T. M., Weintraub, S., Mesulam, M. M. & Rogalski, E. Superior memory and higher cortical volumes in unusually successful cognitive aging. J. Int. Neuropsychol. Soc. 18, 1081\u20131085 (2012).","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10169_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1162\/jocn_a_00300","volume":"25","author":"EJ Rogalski","year":"2013","unstructured":"Rogalski, E. J. et al. Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project. J. Cogn. Neurosci. 25, 29\u201336 (2013).","journal-title":"J. Cogn. Neurosci."},{"key":"10169_CR16","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.cell.2016.10.021","volume":"167","author":"JT Goncalves","year":"2016","unstructured":"Goncalves, J. T., Schafer, S. T. & Gage, F. H. Adult neurogenesis in the hippocampus: from stem cells to behavior. Cell 167, 897\u2013914 (2016).","journal-title":"Cell"},{"key":"10169_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41380-018-0036-2","volume":"24","author":"T Toda","year":"2019","unstructured":"Toda, T., Parylak, S. L., Linker, S. B. & Gage, F. H. The role of adult hippocampal neurogenesis in brain health and disease. Mol. Psychiatry 24, 67\u201387 (2019).","journal-title":"Mol. Psychiatry"},{"key":"10169_CR18","doi-asserted-by":"publisher","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","volume":"7","author":"G Kempermann","year":"2015","unstructured":"Kempermann, G., Song, H. & Gage, F. H. Neurogenesis in the adult hippocampus. Cold Spring Harb. Perspect. Biol. 7, a018812 (2015).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10169_CR19","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1126\/science.1214956","volume":"335","author":"A Marin-Burgin","year":"2012","unstructured":"Marin-Burgin, A., Mongiat, L. A., Pardi, M. B. & Schinder, A. F. Unique processing during a period of high excitation\/inhibition balance in adult-born neurons. Science 335, 1238\u20131242 (2012).","journal-title":"Science"},{"key":"10169_CR20","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nn1847","volume":"10","author":"N Kee","year":"2007","unstructured":"Kee, N., Teixeira, C. M., Wang, A. H. & Frankland, P. W. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat. Neurosci. 10, 355\u2013362 (2007).","journal-title":"Nat. Neurosci."},{"key":"10169_CR21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220391","volume":"219","author":"R Mishra","year":"2022","unstructured":"Mishra, R. et al. Augmenting neurogenesis rescues memory impairments in Alzheimer\u2019s disease by restoring the memory-storing neurons. J. Exp. Med. 219, e20220391 (2022).","journal-title":"J. Exp. Med."},{"key":"10169_CR22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70586","volume":"11","author":"H Twarkowski","year":"2022","unstructured":"Twarkowski, H., Steininger, V., Kim, M. J. & Sahay, A. A dentate gyrus\u2013CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation. eLife 11, e70586 (2022).","journal-title":"eLife"},{"key":"10169_CR23","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1002\/jnr.22387","volume":"88","author":"M Demars","year":"2010","unstructured":"Demars, M., Hu, Y. S., Gadadhar, A. & Lazarov, O. Impaired neurogenesis is an early event in the etiology of familial Alzheimer\u2019s disease in transgenic mice. J. Neurosci. Res. 88, 2103\u20132117 (2010).","journal-title":"J. Neurosci. Res."},{"key":"10169_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/bs.pmbts.2020.09.002","volume":"177","author":"A Disouky","year":"2021","unstructured":"Disouky, A. & Lazarov, O. Adult hippocampal neurogenesis in Alzheimer\u2019s disease. Prog. Mol. Biol. Transl. Sci. 177, 137\u2013156 (2021).","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10169_CR25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13024-017-0207-7","volume":"12","author":"C Hollands","year":"2017","unstructured":"Hollands, C. et al. Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer\u2019s disease by compromising hippocampal inhibition. Mol. Neurodegener. 12, 64 (2017).","journal-title":"Mol. Neurodegener."},{"key":"10169_CR26","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1523\/JNEUROSCI.4767-10.2011","volume":"31","author":"A Gadadhar","year":"2011","unstructured":"Gadadhar, A., Marr, R. A. & Lazarov, O. Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. J. Neurosci. 31, 2615\u20132623 (2011).","journal-title":"J. Neurosci."},{"key":"10169_CR27","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.neuron.2023.03.010","volume":"111","author":"G Tosoni","year":"2023","unstructured":"Tosoni, G. et al. Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?\u00a0Neuron 111, 1714\u20131731 (2023).","journal-title":"Neuron"},{"key":"10169_CR28","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209620","volume":"17","author":"C Xu","year":"2021","unstructured":"Xu, C. et al. Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models. Mol. Syst. Biol. 17, e9620 (2021).","journal-title":"Mol. Syst. Biol."},{"key":"10169_CR29","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/s41592-018-0229-2","volume":"15","author":"R Lopez","year":"2018","unstructured":"Lopez, R., Regier, J., Cole, M. B., Jordan, M. I. & Yosef, N. Deep generative modeling for single-cell transcriptomics. Nat. Methods 15, 1053\u20131058 (2018).","journal-title":"Nat. Methods"},{"key":"10169_CR30","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","volume":"560","author":"G La Manno","year":"2018","unstructured":"La Manno, G. et al. RNA velocity of single cells. Nature 560, 494\u2013498 (2018).","journal-title":"Nature"},{"key":"10169_CR31","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1038\/s41591-024-03150-z","volume":"30","author":"X Chen","year":"2024","unstructured":"Chen, X. et al. A brain cell atlas integrating single-cell transcriptomes across human brain regions. Nat. Med. 30, 2679\u20132691 (2024).","journal-title":"Nat. Med."},{"key":"10169_CR32","doi-asserted-by":"crossref","unstructured":"Habib, N. et al. Div-Seq: single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons. Science 353, 925\u2013928 (2016).","DOI":"10.1126\/science.aad7038"},{"key":"10169_CR33","doi-asserted-by":"publisher","DOI":"10.1126\/science.add7046","volume":"382","author":"K Siletti","year":"2023","unstructured":"Siletti, K. et al. Transcriptomic diversity of cell types across the adult human brain. Science 382, eadd7046 (2023).","journal-title":"Science"},{"key":"10169_CR34","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1016\/j.cell.2025.06.031","volume":"188","author":"Z Liu","year":"2025","unstructured":"Liu, Z. et al. Single-cell multiregion epigenomic rewiring in Alzheimer\u2019s disease progression and cognitive resilience. Cell 188, 4980\u20135002 (2025).","journal-title":"Cell"},{"key":"10169_CR35","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1016\/j.cell.2023.08.039","volume":"186","author":"H Mathys","year":"2023","unstructured":"Mathys, H. et al. Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer\u2019s disease pathology. Cell 186, 4365\u20134385 (2023).","journal-title":"Cell"},{"key":"10169_CR36","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1093\/brain\/awab446","volume":"145","author":"S Smajic","year":"2022","unstructured":"Smajic, S. et al. Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain 145, 964\u2013978 (2022).","journal-title":"Brain"},{"key":"10169_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4564-6","volume":"19","author":"D Sugiaman-Trapman","year":"2018","unstructured":"Sugiaman-Trapman, D. et al. Characterization of the human RFX transcription factor family by regulatory and target gene analysis. BMC Genomics 19, 181 (2018).","journal-title":"BMC Genomics"},{"key":"10169_CR38","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/BF02088833","volume":"14","author":"KH Schlingensiepen","year":"1994","unstructured":"Schlingensiepen, K. H. et al. The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo. Cell. Mol. Neurobiol. 14, 487\u2013505 (1994).","journal-title":"Cell. Mol. Neurobiol."},{"key":"10169_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2023.100263","volume":"3","author":"AG Anderson","year":"2023","unstructured":"Anderson, A. G. et al. Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer\u2019s disease-specific cis-regulatory elements. Cell Genom. 3, 100263 (2023).","journal-title":"Cell Genom."},{"key":"10169_CR40","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/s41592-023-01938-4","volume":"20","author":"C Bravo Gonzalez-Blas","year":"2023","unstructured":"Bravo Gonzalez-Blas, C. et al. SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks. Nat. Methods 20, 1355\u20131367 (2023).","journal-title":"Nat. Methods"},{"key":"10169_CR41","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nmeth.3971","volume":"13","author":"L Haghverdi","year":"2016","unstructured":"Haghverdi, L., Buttner, M., Wolf, F. A., Buettner, F. & Theis, F. J. Diffusion pseudotime robustly reconstructs lineage branching. Nat. Methods 13, 845\u2013848 (2016).","journal-title":"Nat. Methods"},{"key":"10169_CR42","doi-asserted-by":"publisher","first-page":"7426","DOI":"10.1073\/pnas.0500334102","volume":"102","author":"RR Coifman","year":"2005","unstructured":"Coifman, R. R. et al. Geometric diffusions as a tool for harmonic analysis and structure definition of data: diffusion maps. Proc. Natl Acad. Sci. USA 102, 7426\u20137431 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10169_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0","volume":"19","author":"FA Wolf","year":"2018","unstructured":"Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).","journal-title":"Genome Biol."},{"key":"10169_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"TJ Montine","year":"2012","unstructured":"Montine, T. J. et al. National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach. Acta Neuropathol. 123, 1\u201311 (2012).","journal-title":"Acta Neuropathol."},{"key":"10169_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","volume":"8","author":"BT Hyman","year":"2012","unstructured":"Hyman, B. T. et al. National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease. Alzheimers Dement. 8, 1\u201313 (2012).","journal-title":"Alzheimers Dement."},{"key":"10169_CR46","unstructured":"Rey, S. M. Auditory Verbal Learning Test: A Handbook (Western Psychological Services, 2004)."},{"key":"10169_CR47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/alzrt94","volume":"3","author":"SD Shirk","year":"2011","unstructured":"Shirk, S. D. et al. A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery. Alzheimers Res. Ther. 3, 32 (2011).","journal-title":"Alzheimers Res. Ther."},{"key":"10169_CR48","unstructured":"Heaton, R., Miller, S., Taylor, M. & Grant, I. Revised Comprehensive Norms for an Expanded Halstead-Reitan Battery: Demographically Adjusted Neuropsychological Norms for African American and Caucasian Adults (Psychological Assessment Resources, 2004)."},{"key":"10169_CR49","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"10169_CR50","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","volume":"8","author":"SL Wolock","year":"2019","unstructured":"Wolock, S. L., Lopez, R. & Klein, A. M. Scrublet: computational identification of cell doublets in single-cell transcriptomic data. Cell Syst. 8, 281\u2013291 (2019).","journal-title":"Cell Syst"},{"key":"10169_CR51","doi-asserted-by":"publisher","unstructured":"Shor, J. JonathanShor\/DoubletDetection: doubletdetection v4.3.0.post1. Zenodo https:\/\/doi.org\/10.5281\/zenodo.14827937 (2025).","DOI":"10.5281\/zenodo.14827937"},{"key":"10169_CR52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41587-021-01206-w","volume":"40","author":"A Gayoso","year":"2022","unstructured":"Gayoso, A. et al. A Python library for probabilistic analysis of single-cell omics data. Nat. Biotechnol. 40, 163\u2013166 (2022).","journal-title":"Nat. Biotechnol."},{"key":"10169_CR53","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.tins.2004.05.013","volume":"27","author":"G Kempermann","year":"2004","unstructured":"Kempermann, G., Jessberger, S., Steiner, B. & Kronenberg, G. Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 27, 447\u2013452 (2004).","journal-title":"Trends Neurosci."},{"key":"10169_CR54","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1126\/science.aax0249","volume":"367","author":"GS Gulati","year":"2020","unstructured":"Gulati, G. S. et al. Single-cell transcriptional diversity is a hallmark of developmental potential. Science 367, 405\u2013411 (2020).","journal-title":"Science"},{"key":"10169_CR55","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","volume":"38","author":"V Bergen","year":"2020","unstructured":"Bergen, V., Lange, M., Peidli, S., Wolf, F. A. & Theis, F. J. Generalizing RNA velocity to transient cell states through dynamical modeling. Nat. Biotechnol. 38, 1408\u20131414 (2020).","journal-title":"Nat. Biotechnol."},{"key":"10169_CR56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010).","journal-title":"Bioinformatics"},{"key":"10169_CR57","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1093\/bioinformatics\/btx804","volume":"34","author":"A Khan","year":"2018","unstructured":"Khan, A. & Mathelier, A. JASPAR RESTful API: accessing JASPAR data from any programming language. Bioinformatics 34, 1612\u20131614 (2018).","journal-title":"Bioinformatics"},{"key":"10169_CR58","doi-asserted-by":"publisher","first-page":"W202","DOI":"10.1093\/nar\/gkp335","volume":"37","author":"TL Bailey","year":"2009","unstructured":"Bailey, T. L. et al. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res. 37, W202\u2013W208 (2009).","journal-title":"Nucleic Acids Res."},{"key":"10169_CR59","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"2018","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the False discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. 57, 289\u2013300 (2018).","journal-title":"J. R. Stat. Soc."},{"key":"10169_CR60","doi-asserted-by":"publisher","first-page":"D174","DOI":"10.1093\/nar\/gkad1059","volume":"52","author":"I Rauluseviciute","year":"2024","unstructured":"Rauluseviciute, I. et al. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 52, D174\u2013D182 (2024).","journal-title":"Nucleic Acids Res."},{"key":"10169_CR61","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","volume":"27","author":"CE Grant","year":"2011","unstructured":"Grant, C. E., Bailey, T. L. & Noble, W. S. FIMO: scanning for occurrences of a given motif. Bioinformatics 27, 1017\u20131018 (2011).","journal-title":"Bioinformatics"},{"key":"10169_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell\u2013cell communication using CellChat. Nat. Commun. 12, 1088 (2021).","journal-title":"Nat. Commun."},{"key":"10169_CR63","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-10169-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-10169-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-10169-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:02:01Z","timestamp":1777734121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-026-10169-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":63,"journal-issue":{"issue":"8112","published-print":{"date-parts":[[2026,4,30]]}},"alternative-id":["10169"],"URL":"https:\/\/doi.org\/10.1038\/s41586-026-10169-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4469965\/v1","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"24 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the version of the article initially published, the text \u201cThis project was supported by NIA AG067781 and U19AG073153 (Geula, Mesulam and Rogalski), and the McKnight Brain Research Foundation (MBRF)\u201d was missing from the Acknowledgements section and has now been added to the HTML and PDF versions of the article.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}