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D.G.M. is a paid advisor to Insitro and GSK, and receives research funding from Google and Microsoft, unrelated to the work described in this paper. G.A.F. reports grants from the NHMRC (Australia), grants from Abbott Diagnostic, Sanofi, Janssen Pharmaceuticals and NSW Health. G.A.F. reports honoraria from CSL, CPC Clinical Research, Sanofi, Boehringer Ingelheim, Heart Foundation and Abbott. G.A.F. serves as Board Director for the Australian Cardiovascular Alliance (past President), Executive Committee Member for CPC Clinical Research, Founding Director and CMO for Prokardia and Kardiomics, and Executive Committee member for the CAD Frontiers A2D2 Consortium. In addition, G.A.F. serves as CMO for the non-profit, CAD Frontiers, with industry partners including Novartis, Amgen, Siemens Healthineers, ELUCID, Foresite Laboratories LLC, HeartFlow, Canon, Cleerly, Caristo, Genentech, Artyra, Bitterroot Bio, Novo Nordisk and Allelica. In addition, G.A.F. has the following patents: \u2018Patent Biomarkers and Oxidative Stress\u2019 awarded USA May 2017 (grant no. US9638699B2) issued to Northern Sydney Local Health District, \u2018Use of P2X7R antagonists in cardiovascular disease\u2019 PCT\/AU2018\/050905 licensed to Prokardia, \u2018\n                      \n                      for treatment and prevention of vascular disease\u2019 PCT\/AU2015\/000548 issued to The University of Sydney\/Northern Sydney Local Health District, \u2018\n                      \n                      for predicting coronary artery disease\u2019 AU202290266 issued to The University of Sydney and the patent \u2018Novel P2X7 Receptor Antagonists\u2019 PCT\/AU2022\/051400 (23 November 2022), International App No. WO\/2023\/092175 (1 June 2023), issued to The University of Sydney. C.W. is a part-time employee of GSK. GSK had no role in this study or the decision to publish. E.D. is an employee and shareholder of Pacific Biosciences. 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