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J.A.D. is a co-founder of Aurora, Azalea Therapeutics, Caribou Biosciences, Editas Medicine, Scribe Therapeutics and Mammoth Biosciences. J.A.D. is a scientific advisory board member at BEVC Management, Caribou Biosciences, Scribe Therapeutics, Isomorphic Labs, The Column Group and Inari; and also an adviser for Aditum Bio. J.A.D. is chief science adviser to Sixth Street and a director at Johnson & Johnson, Altos and Tempus. A.A. is a co-founder of Azkarra Therapeutics, Kytarro, Ovibio Corporation, Tango Therapeutics and Tiller Tx; is a member of the board of Cambridge Science Corporation, Cytomx and Ovibio, a member of the scientific advisory board of Ambagon, ClearNote Health (formerly Bluestar), Circle, GLAdiator Biosciences, HAP10, Interdict Bio, Earli, ORIC Pharmaceuticals, Phoenix Molecular Designs, Trial Library and 280Bio (Yingli); is a consultant for Next RNA, Novartis and ProLynx; and holds patents on the use of PARP inhibitors, jointly with AstraZeneca from which he has benefited financially (and may do so in the future). N.M. is a cofounder of Genedit, Microbial Medical and Opus Biosciences. The other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}