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The amygdala is integral to emotion and stress responses\n                    <jats:sup>1<\/jats:sup>\n                    and comprises astrocytes,\u00a0neurons\u00a0and other cells. Here we show that\u00a0amygdala astrocytes contribute to stress-related behaviours through signalling mechanisms related to their primary cilia\n                    <jats:sup>2<\/jats:sup>\n                    . Amygdala astrocytes are altered during stress at the protein and gene expression level, display reduced expression of molecules related to primary cilia\n                    <jats:sup>3,4<\/jats:sup>\n                    and have morphologically short primary cilia\n                    <jats:sup>5,6<\/jats:sup>\n                    . G\u2009protein-coupled receptors (GPCRs) are central to astrocyte\n                    <jats:sup>7<\/jats:sup>\n                    and primary cilia\n                    <jats:sup>2,8,9<\/jats:sup>\n                    function. Therefore, we speculated that GPCR signalling activation might be beneficial in stress-related behavioural disorders. We identified amygdala astrocyte GPCRs as regulators of responses following stress. Chemogenetics and targeting of native sphingosine-1-phosphate receptor 1 (S1PR1) GPCRs led to the restoration of astrocyte primary cilia length, corrected molecular alterations and improved stress-related behaviours. Cilium-related genes were abundantly expressed in human amygdala astrocytes, with many displaying disrupted expression in stress-related brain disorders. S1PR1 was also highly expressed in amygdala astrocytes from human tissue. Selective genetic disruption of amygdala astrocyte primary cilia in mice altered some stress-related behaviours and gene expression of astrocytes and parenchymal cells. These data confirm that astrocytic cilia have important\u00a0roles in this brain nucleus. In summary, amygdala astrocytes and their primary cilia are disrupted during stress, and their restoration is accompanied by stress-related molecular and behavioural improvements. Astrocyte primary cilia-related mechanisms may therefore provide new treatment strategies for stress-related and other brain disorders.\n                  <\/jats:p>","DOI":"10.1038\/s41586-026-10874-0","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:02:32Z","timestamp":1785942152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-3172","authenticated-orcid":false,"given":"Sara G.","family":"Pelaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-2302","authenticated-orcid":false,"given":"Katsukuni","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kolosowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-256X","authenticated-orcid":false,"given":"Haley","family":"Fritch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-9331","authenticated-orcid":false,"given":"Chiranjivi","family":"Neupane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-740X","authenticated-orcid":false,"given":"Vanessa H.","family":"Casha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Alonso-Gard\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-5504","authenticated-orcid":false,"given":"Vijaya","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-901X","authenticated-orcid":false,"given":"James A.","family":"Wohlschlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1031-8798","authenticated-orcid":false,"given":"Jiami","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-8184","authenticated-orcid":false,"given":"Steven A.","family":"McCarroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-7766","authenticated-orcid":false,"given":"Sabina","family":"Berretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-1218","authenticated-orcid":false,"given":"Baljit S.","family":"Khakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"10874_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","volume":"34","author":"EJ Nestler","year":"2002","unstructured":"Nestler, E. 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