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Altered brain lipid composition is associated with common and rare neuropathologies, yet the spatial organization of the mammalian brain lipidome remains insufficiently characterized compared with other modalities\n                    <jats:sup>1\u20136<\/jats:sup>\n                    . Here we mapped the membrane-lipid architecture of the adult mouse brain at micrometric scale, across sexes and during pregnancy. This lipid brain atlas reveals that lipids describe a fine-grained biochemical structure that aligns with functional anatomy. Membrane-lipid spatial heterogeneity clusters into territories, which we termed \u2018lipizones\u2019. Lipizones partially mirror cell-type territories, but also capture distal axon terminals. Through lipizones, we (1) reveal the organizing principles of the grey matter lipidome, related to connectivity and cytoarchitecture; (2) discover a new axis of oligodendrocyte heterogeneity in the white matter; and (3) find biochemical zonation in the choroid plexus and in the ventricular walls. We show that this lipidomic architecture can adapt to changing physiological needs. In the brain of pregnant female\u00a0mice, the white matter is metabolically activated and the cortex undergoes a lipizone-specific remodelling that is\u00a0particularly pronounced in layer\u20094. These results are a foundational resource (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/lbae-v2.epfl.ch\/\" ext-link-type=\"uri\">https:\/\/lbae-v2.epfl.ch\/<\/jats:ext-link>\n                    ) poised to reshape the understanding of lipids in brain development, physiology and pathology.\n                  <\/jats:p>","DOI":"10.1038\/s41586-026-11050-0","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:03:46Z","timestamp":1790175826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The lipidomic architecture of the mouse brain"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8256-8074","authenticated-orcid":false,"given":"Luca","family":"Fusar Bassini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7026-1676","authenticated-orcid":false,"given":"Halima Hannah","family":"Schede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Capolupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-2606","authenticated-orcid":false,"given":"Leila","family":"Haj Abdullah Alieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmak","family":"Kaysudu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2754-0444","authenticated-orcid":false,"given":"Francesca","family":"Venturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Hochgerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Valente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colas","family":"Droin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Trejo Banos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Khven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8709-640X","authenticated-orcid":false,"given":"Jean Andrea","family":"Maillat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-5483","authenticated-orcid":false,"given":"Anne-Laure","family":"Mahul-Mellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Asaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-8593","authenticated-orcid":false,"given":"Do\u011fukan H.","family":"\u00dclgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-5717","authenticated-orcid":false,"given":"Pavel","family":"Barahtjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece Z.","family":"Asirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Nasrallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-8321","authenticated-orcid":false,"given":"Carmen","family":"Sandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-3451","authenticated-orcid":false,"given":"Ekaterina","family":"Krymova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-4127","authenticated-orcid":false,"given":"Giovanni","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-8757","authenticated-orcid":false,"given":"Gioele","family":"La Manno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"11050_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41586-023-06818-7","volume":"624","author":"J Langlieb","year":"2023","unstructured":"Langlieb, J. et al. 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