{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:11:40Z","timestamp":1789031500669,"version":"build-2803163510"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our Future Health is a prospective study aiming to recruit 5\u2009million UK-resident adults to enable discovery and translation of disease prevention, detection and treatment approaches. So far, more than 2.5\u2009million have enrolled, and baseline phenotypic data are available for &gt;1.9\u2009million participants. Here we provide an assessment of phenotypes\u2014self-reported health-related behaviors, geolocation, diagnoses and medication, in- and outpatient visits, cancer registry and cause of death\u2014and comparison of disease patterns against national estimates and the UK Biobank cohort. Sociodemographic, lifestyle and health-related characteristics reflected UK population patterns; all but one minority ethnic group and the most socioeconomically deprived groups were underrepresented. The prevalence of several major self-reported conditions, particularly mental health conditions such as depression and anxiety, was higher than national estimates and directionally concordant with the UK Biobank (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.78). Associations with known clinical correlates replicated across both cohorts (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.80). Medication-use patterns and cancer prevalence followed expected age-related gradients, with lower lung cancer rates than national data. As recruitment progresses, electronic health records can help specify disease patterns and systematically assess biases.\n                  <\/jats:p>","DOI":"10.1038\/s41591-026-04602-4","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:04:03Z","timestamp":1789031043000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-6027","authenticated-orcid":false,"given":"Vincent J.","family":"Straub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-514X","authenticated-orcid":false,"given":"Stefania","family":"Benonisdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8381-6079","authenticated-orcid":false,"given":"Giovanni Scotti","family":"Bentivoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-276X","authenticated-orcid":false,"given":"Neil","family":"Wary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0212-224X","authenticated-orcid":false,"given":"Robert","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-5438","authenticated-orcid":false,"given":"Augustine","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1704-0001","authenticated-orcid":false,"given":"Melinda C.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"4602_CR1","doi-asserted-by":"crossref","unstructured":"Building healthy populations. 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M.C.M. was a research ambassador for OFH, is a trustee and on the ethics advisory board of the UKB, was previously on the scientific and is currently on the ethics advisory boards of OFH and is on the advisory boards of the Netherlands Lifelines Biobank, US Health and Retirement Survey and UK CLS Cohort Studies. S.B. is a part of a working group called Alzheimer Diagnostics that has received a grant from the Icelandic Technology Development fund. The other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}