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Here we describe the functionality of tangermeme, a highly optimized toolkit for \u2018everything-but-the-model\u2019 when it comes to genomic deep learning, and demonstrate how tangermeme can be used to distill the learned\n                    <jats:italic>cis-<\/jats:italic>\n                    regulatory patterns from models into human-interpretable insights.\n                  <\/jats:p>","DOI":"10.1038\/s41592-026-03254-z","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:02:39Z","timestamp":1791450159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning models"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-6625","authenticated-orcid":false,"given":"Jacob","family":"Schreiber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"3254_CR1","doi-asserted-by":"crossref","unstructured":"Winters-Hilt, S. 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