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However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. These differences may be attributed to protocol differences, although it is difficult to identify the relevant conditions because detailed comet assay procedures are not always published. Here, we present a Consensus Statement for the Minimum Information for Reporting Comet Assay (MIRCA) providing recommendations for describing comet assay conditions and results. These recommendations differentiate between \u2018desirable\u2019 and \u2018essential\u2019 information: \u2018essential\u2019 information refers to the precise details that are necessary to assess the quality of the experimental work, whereas \u2018desirable\u2019 information relates to technical issues that might be encountered when repeating the experiments. Adherence to MIRCA recommendations should ensure that comet assay results can be easily interpreted and independently verified by other researchers.<\/jats:p>","DOI":"10.1038\/s41596-020-0398-1","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T17:03:18Z","timestamp":1603731798000},"page":"3817-3826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":324,"title":["Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-1249","authenticated-orcid":false,"given":"Peter","family":"M\u00f8ller","sequence":"first","affiliation":[]},{"given":"Amaya","family":"Azqueta","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-4568","authenticated-orcid":false,"given":"Elisa","family":"Boutet-Robinet","sequence":"additional","affiliation":[]},{"given":"Gudrun","family":"Koppen","sequence":"additional","affiliation":[]},{"given":"Stefano","family":"Bonassi","sequence":"additional","affiliation":[]},{"given":"Mirta","family":"Mili\u0107","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-1453","authenticated-orcid":false,"given":"Goran","family":"Gajski","sequence":"additional","affiliation":[]},{"given":"Solange","family":"Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-5250","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Teixeira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-1223","authenticated-orcid":false,"given":"Cristiana","family":"Costa Pereira","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Dusinska","sequence":"additional","affiliation":[]},{"given":"Roger","family":"Godschalk","sequence":"additional","affiliation":[]},{"given":"Gunnar","family":"Brunborg","sequence":"additional","affiliation":[]},{"given":"Kristine B.","family":"Gutzkow","sequence":"additional","affiliation":[]},{"given":"Lisa","family":"Giovannelli","sequence":"additional","affiliation":[]},{"given":"Marcus S.","family":"Cooke","sequence":"additional","affiliation":[]},{"given":"Elke","family":"Richling","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7649-2599","authenticated-orcid":false,"given":"Blanca","family":"Laffon","sequence":"additional","affiliation":[]},{"given":"Vanessa","family":"Valdiglesias","sequence":"additional","affiliation":[]},{"given":"Nursen","family":"Basaran","sequence":"additional","affiliation":[]},{"given":"Cristian","family":"Del Bo\u2019","sequence":"additional","affiliation":[]},{"given":"Bojana","family":"Zegura","sequence":"additional","affiliation":[]},{"given":"Matjaz","family":"Novak","sequence":"additional","affiliation":[]},{"given":"Helga","family":"Stopper","sequence":"additional","affiliation":[]},{"given":"Pavel","family":"Vodicka","sequence":"additional","affiliation":[]},{"given":"Sona","family":"Vodenkova","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-4482","authenticated-orcid":false,"given":"Vanessa Moraes","family":"de Andrade","sequence":"additional","affiliation":[]},{"given":"Monika","family":"Sramkova","sequence":"additional","affiliation":[]},{"given":"Alena","family":"Gabelova","sequence":"additional","affiliation":[]},{"given":"Andrew","family":"Collins","sequence":"additional","affiliation":[]},{"given":"Sabine A. 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