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A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in research data repositories in a FAIR manner. Nevertheless, in order to make chemistry a sustainable discipline, obtaining FAIR data is insufficient and a comprehensive concept that includes preservation of materials is needed. In order to offer a comprehensive infrastructure to find and access data and materials that were generated in chemistry projects, we combined the infrastructure Chemotion repository with an archive for chemical compounds. Samples play a key role in this concept: we describe how FAIR metadata of a virtual sample representation can be used to refer to a physically available sample in a materials\u2019 archive and to link it with the FAIR research data gained using the said sample. We further describe the measures to make the physically available samples not only FAIR through their metadata but also findable, accessible and reusable.<\/jats:p>","DOI":"10.1038\/s41597-025-04404-2","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T09:01:12Z","timestamp":1737536472000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Linking Research Data with Physically Preserved Research Materials in Chemistry"],"prefix":"10.1038","volume":"12","author":[{"given":"Chia-Lin","family":"Lin","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-4507","authenticated-orcid":false,"given":"Pei-Chi","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Simone","family":"Gr\u00e4\u00dfle","sequence":"additional","affiliation":[]},{"given":"Christoph","family":"Grathwol","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-3947","authenticated-orcid":false,"given":"Pierre","family":"Tremouilhac","sequence":"additional","affiliation":[]},{"given":"Sylvia","family":"Vanderheiden","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-5059","authenticated-orcid":false,"given":"Patrick","family":"Hodapp","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-4353","authenticated-orcid":false,"given":"Sonja","family":"Herres-Pawlis","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Hoffmann","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-2087","authenticated-orcid":false,"given":"Fabian","family":"Fink","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-5757","authenticated-orcid":false,"given":"Georg","family":"Manolikakes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-4050","authenticated-orcid":false,"given":"Till","family":"Opatz","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-6636","authenticated-orcid":false,"given":"Andreas","family":"Link","sequence":"additional","affiliation":[]},{"given":"M. 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