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Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1) mediates protection against IRI. However, the role of myeloid HO-1 during IRI remains poorly characterized. Mice with myeloid-restricted deletion of HO-1 (HO-1<jats:sup>M-KO<\/jats:sup>), littermate (LT), and wild-type (WT) mice were subjected to renal IRI or sham procedures and sacrificed after 24\u2009hours or 7 days. In comparison to LT, HO-1<jats:sup>M-KO<\/jats:sup> exhibited significant renal histological damage, pro-inflammatory responses and oxidative stress 24\u2009hours after reperfusion. HO-1<jats:sup>M-KO<\/jats:sup> mice also displayed impaired tubular repair and increased renal fibrosis 7 days after IRI. In WT mice, HO-1 induction with hemin specifically upregulated HO-1 within the CD11b<jats:sup>+<\/jats:sup> F4\/80<jats:sup>lo<\/jats:sup> subset of the renal myeloid cells. Prior administration of hemin to renal IRI was associated with significant increase of the renal HO-1<jats:sup>+<\/jats:sup> CD11b<jats:sup>+<\/jats:sup> F4\/80<jats:sup>lo<\/jats:sup> myeloid cells in comparison to control mice. In contrast, this hemin-mediated protection was abolished in HO-1<jats:sup>M-KO<\/jats:sup> mice. In conclusion, myeloid HO-1 appears as a critical protective pathway against renal IRI and could be an interesting therapeutic target in renal transplantation.<\/jats:p>","DOI":"10.1038\/s41598-017-00220-w","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T16:25:46Z","timestamp":1489076746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury"],"prefix":"10.1038","volume":"7","author":[{"given":"Maxime","family":"Rossi","sequence":"first","affiliation":[]},{"given":"Antoine","family":"Thierry","sequence":"additional","affiliation":[]},{"given":"Sandrine","family":"Delbauve","sequence":"additional","affiliation":[]},{"given":"Nicolas","family":"Preyat","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-4833","authenticated-orcid":false,"given":"Miguel P.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Thierry","family":"Roumegu\u00e8re","sequence":"additional","affiliation":[]},{"given":"Oberdan","family":"Leo","sequence":"additional","affiliation":[]},{"given":"V\u00e9ronique","family":"Flamand","sequence":"additional","affiliation":[]},{"given":"Alain","family":"Le Moine","sequence":"additional","affiliation":[]},{"given":"Jean-Michel","family":"Hougardy","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"220_CR1","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1172\/JCI45161","volume":"121","author":"JV Bonventre","year":"2011","unstructured":"Bonventre, J. 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