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This enzyme is encoded by the <jats:italic>mecA<\/jats:italic> gene located within the Staphylococcal Chromosome Cassette <jats:italic>mec<\/jats:italic> (SCC<jats:italic>mec<\/jats:italic>) mobile genetic element, of which there are 12 types described to date. Previous investigations aimed at analysing the synergistic activity of two \u03b2-lactams, oxacillin and cefoxitin, found that SCC<jats:italic>mec<\/jats:italic> type IV community-acquired MRSA strains exhibited increased susceptibility to oxacillin in the presence of cefoxitin, while hospital-acquired MRSA strains were unaffected. However, it is not clear if these differences in \u03b2-lactam resistance are indeed a consequence of the presence of the different SCC<jats:italic>mec<\/jats:italic> types. To address this question, we have exchanged the SCC<jats:italic>mec<\/jats:italic> type I in COL (HA-MRSA) for the SCC<jats:italic>mec<\/jats:italic> type IV from MW2 (CA-MRSA). This exchange did not decrease the resistance of COL against oxacillin and cefoxitin, as observed in MW2, indicating that genetic features residing outside of the SCC<jats:italic>mec<\/jats:italic> element are likely to be responsible for the discrepancy in oxacillin and cefoxitin synergy against these MRSA strains.<\/jats:p>","DOI":"10.1038\/s41598-017-06329-2","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T11:49:51Z","timestamp":1500292191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Role of SCCmec type in resistance to the synergistic activity of oxacillin and cefoxitin in MRSA"],"prefix":"10.1038","volume":"7","author":[{"given":"Nathalie T.","family":"Reichmann","sequence":"first","affiliation":[]},{"given":"Mariana G.","family":"Pinho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"6329_CR1","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/NEJM199808203390806","volume":"339","author":"FD Lowy","year":"1998","unstructured":"Lowy, F. 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