{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:25:20Z","timestamp":1770747920936,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI) due to AD. Much less is known whether increased tau plasma levels can already be detected in the pre-MCI stage of subjective cognitive decline (SCD). In the present study we measured tau plasma levels in 111 SCD patients and 134 age- and gender-matched cognitively healthy controls participating in the DZNE (German Center for Neurodegenerative Diseases) longitudinal study on cognition and dementia (DELCODE). Tau plasma levels were measured using ultra-sensitive, single-molecule array (Simoa) technology. We found no significant different tau plasma levels in SCD (3.4\u2009pg\/ml) compared with healthy controls (3.6\u2009pg\/ml) after controlling for age, gender, and education (p\u2009=\u20090.137). In addition, tau plasma levels did not correlate with A\u03b242 (r\u2009=\u20090.073; p\u2009=\u20090.634), tau (r\u2009=\u2009\u22120.179; p\u2009=\u20090.240), and p-tau181 (r\u2009=\u2009\u22120.208; p\u2009=\u20090.171) cerebrospinal fluid (CSF) levels in a subgroup of 45 SCD patients with available CSF. In conclusion, plasma tau is not increased in SCD patients. In addition, the lack of correlation between tau in plasma and CSF in the examined cohort suggests that tau levels are affected by different factors in both biofluids.<\/jats:p>","DOI":"10.1038\/s41598-017-08779-0","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T14:57:11Z","timestamp":1503327431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Tau plasma levels in subjective cognitive decline: Results from the DELCODE study"],"prefix":"10.1038","volume":"7","author":[{"given":"Stephan","family":"M\u00fcller","sequence":"first","affiliation":[]},{"given":"Oliver","family":"Preische","sequence":"additional","affiliation":[]},{"given":"Jens C.","family":"G\u00f6pfert","sequence":"additional","affiliation":[]},{"given":"Viviana A. Carcamo","family":"Ya\u00f1ez","sequence":"additional","affiliation":[]},{"given":"Thomas O.","family":"Joos","sequence":"additional","affiliation":[]},{"given":"Henning","family":"Boecker","sequence":"additional","affiliation":[]},{"given":"Emrah","family":"D\u00fczel","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Falkai","sequence":"additional","affiliation":[]},{"given":"Josef","family":"Priller","sequence":"additional","affiliation":[]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[]},{"given":"Cihan","family":"Catak","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Janowitz","sequence":"additional","affiliation":[]},{"given":"Michael T.","family":"Heneka","sequence":"additional","affiliation":[]},{"given":"Frederic","family":"Brosseron","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Nestor","sequence":"additional","affiliation":[]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[]},{"given":"Felix","family":"Menne","sequence":"additional","affiliation":[]},{"given":"Carola G.","family":"Schipke","sequence":"additional","affiliation":[]},{"given":"Anja","family":"Schneider","sequence":"additional","affiliation":[]},{"given":"Annika","family":"Spottke","sequence":"additional","affiliation":[]},{"given":"Klaus","family":"Flie\u00dfbach","sequence":"additional","affiliation":[]},{"given":"Ingo","family":"Kilimann","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-5330","authenticated-orcid":false,"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[]},{"given":"Christoph","family":"Laske","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"8779_CR1","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","volume":"83","author":"I Grundke-Iqbal","year":"1986","unstructured":"Grundke-Iqbal, I. et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proceedings of the National Academy of Sciences of the United States of America \n                           83, 4913\u20134917 (1986).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8779_CR2","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/brain\/awr038","volume":"134","author":"MT Fodero-Tavoletti","year":"2011","unstructured":"Fodero-Tavoletti, M. T. et al. 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer\u2019s disease. Brain: a journal of neurology \n                           134, 1089\u20131100, doi:10.1093\/brain\/awr038 (2011).","journal-title":"Brain: a journal of neurology"},{"key":"8779_CR3","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1111\/j.1471-4159.1993.tb09823.x","volume":"61","author":"M Vandermeeren","year":"1993","unstructured":"Vandermeeren, M. et al. Detection of tau proteins in normal and Alzheimer\u2019s disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. Journal of neurochemistry \n                           61, 1828\u20131834 (1993).","journal-title":"Journal of neurochemistry"},{"key":"8779_CR4","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1002\/hbm.22390","volume":"35","author":"MJ Chiu","year":"2014","unstructured":"Chiu, M. J. et al. Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early Alzheimer\u2019s disease. Human brain mapping \n                           35, 3132\u20133142, doi:10.1002\/hbm.22390 (2014).","journal-title":"Human brain mapping"},{"key":"8779_CR5","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1212\/WNL.0000000000003246","volume":"87","author":"N Mattsson","year":"2016","unstructured":"Mattsson, N. et al. Plasma tau in Alzheimer disease. 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