{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:07:39Z","timestamp":1768435659234,"version":"3.49.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The head and neck squamous cell carcinoma (HNSCC) population consists mainly of high-risk for recurrence and locally advanced stage patients. Increased knowledge of the HNSCC genomic profile can improve early diagnosis and treatment outcomes. The development of models to identify consistent genomic patterns that distinguish HNSCC patients that will recur and\/or develop metastasis after treatment is of utmost importance to decrease mortality and improve survival rates. In this study, we used array comparative genomic hybridization data from HNSCC patients to implement a robust model to predict HNSCC recurrence\/metastasis. This predictive model showed a good accuracy (&gt;80%) and was validated in an independent population from TCGA data portal. This predictive genomic model comprises chromosomal regions from 5p, 6p, 8p, 9p, 11q, 12q, 15q and 17p, where several upstream and downstream members of signaling pathways that lead to an increase in cell proliferation and invasion are mapped. The introduction of genomic predictive models in clinical practice might contribute to a more individualized clinical management of the HNSCC patients, reducing recurrences and improving patients\u2019 quality of life. The power of this genomic model to predict the recurrence and metastases development should be evaluated in other HNSCC populations.<\/jats:p>","DOI":"10.1038\/s41598-017-14377-x","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T10:42:45Z","timestamp":1508323365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Genomic predictive model for recurrence and metastasis development in head and neck squamous cell carcinoma patients"],"prefix":"10.1038","volume":"7","author":[{"given":"Ilda Patr\u00edcia","family":"Ribeiro","sequence":"first","affiliation":[]},{"given":"Francisco","family":"Caramelo","sequence":"additional","affiliation":[]},{"given":"Lu\u00edsa","family":"Esteves","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Menoita","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Leonor","family":"Barroso","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Migu\u00e9is","sequence":"additional","affiliation":[]},{"given":"Joana Barbosa","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Isabel Marques","family":"Carreira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"14377_CR1","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay, J. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer \n                           127, 2893\u20132917, https:\/\/doi.org\/10.1002\/ijc.25516 (2010).","journal-title":"International journal of cancer"},{"key":"14377_CR2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.critrevonc.2015.03.005","volume":"95","author":"J Thariat","year":"2015","unstructured":"Thariat, J. et al. Integrating genomics in head and neck cancer treatment: Promises and pitfalls. Critical reviews in oncology\/hematology \n                           95, 397\u2013406, https:\/\/doi.org\/10.1016\/j.critrevonc.2015.03.005 (2015).","journal-title":"Critical reviews in oncology\/hematology"},{"key":"14377_CR3","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1586\/era.11.135","volume":"11","author":"MJ Worsham","year":"2011","unstructured":"Worsham, M. J. Identifying the risk factors for late-stage head and neck cancer. Expert review of anticancer therapy \n                           11, 1321\u20131325, https:\/\/doi.org\/10.1586\/era.11.135 (2011).","journal-title":"Expert review of anticancer therapy"},{"key":"14377_CR4","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/S0140-6736(08)60728-X","volume":"371","author":"A Argiris","year":"2008","unstructured":"Argiris, A., Karamouzis, M. V., Raben, D. & Ferris, R. L. Head and neck cancer. Lancet \n                           371, 1695\u20131709, https:\/\/doi.org\/10.1016\/S0140-6736(08)60728-X (2008).","journal-title":"Lancet"},{"key":"14377_CR5","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","volume":"359","author":"JB Vermorken","year":"2008","unstructured":"Vermorken, J. B. et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. The New England journal of medicine \n                           359, 1116\u20131127, https:\/\/doi.org\/10.1056\/NEJMoa0802656 (2008).","journal-title":"The New England journal of medicine"},{"key":"14377_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1758-3284-2-9","volume":"2","author":"W Jerjes","year":"2010","unstructured":"Jerjes, W. et al. Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. Head & neck oncology \n                           2, 9, https:\/\/doi.org\/10.1186\/1758-3284-2-9 (2010).","journal-title":"Head & neck oncology"},{"key":"14377_CR7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/BF03262210","volume":"16","author":"MJ Worsham","year":"2012","unstructured":"Worsham, M. J., Ali, H., Dragovic, J. & Schweitzer, V. P. Molecular characterization of head and neck cancer: how close to personalized targeted therapy? Molecular diagnosis & therapy \n                           16, 209\u2013222, https:\/\/doi.org\/10.2165\/11635330-000000000-00000 (2012).","journal-title":"Molecular diagnosis & therapy"},{"key":"14377_CR8","doi-asserted-by":"publisher","first-page":"4599","DOI":"10.1007\/s13277-013-1604-3","volume":"35","author":"R Pinto-Leite","year":"2014","unstructured":"Pinto-Leite, R. et al. Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer. Tumour Biol \n                           35, 4599\u20134617, https:\/\/doi.org\/10.1007\/s13277-013-1604-3 (2014).","journal-title":"Tumour Biol"},{"key":"14377_CR9","doi-asserted-by":"publisher","unstructured":"Sever, R. & Brugge, J. S. Signal transduction in cancer. Cold Spring Harbor perspectives in medicine \n                           5, https:\/\/doi.org\/10.1101\/cshperspect.a006098 (2015).","DOI":"10.1101\/cshperspect.a006098"},{"key":"14377_CR10","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.tripleo.2010.11.020","volume":"111","author":"J-D Cha","year":"2011","unstructured":"Cha, J.-D., Kim, H. J. & Cha, I.-H. Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology \n                           111, 594\u2013607, https:\/\/doi.org\/10.1016\/j.tripleo.2010.11.020 (2011).","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"},{"key":"14377_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/path.1640","volume":"204","author":"YJ Chen","year":"2004","unstructured":"Chen, Y. J. et al. Genome-wide profiling of oral squamous cell carcinoma. The Journal of pathology \n                           204, 326\u2013332, https:\/\/doi.org\/10.1002\/path.1640 (2004).","journal-title":"The Journal of pathology"},{"key":"14377_CR12","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/01.mlg.0000205141.54471.7f","volume":"116","author":"A Sparano","year":"2006","unstructured":"Sparano, A. et al. Genome-wide profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization. The Laryngoscope \n                           116, 735\u2013741, https:\/\/doi.org\/10.1097\/01.mlg.0000205141.54471.7f (2006).","journal-title":"The Laryngoscope"},{"key":"14377_CR13","doi-asserted-by":"publisher","unstructured":"Ribeiro, I. P. et al. Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management. Cell Oncol (Dordr), https:\/\/doi.org\/10.1007\/s13402-013-0161-5 (2014).","DOI":"10.1007\/s13402-013-0161-5"},{"key":"14377_CR14","doi-asserted-by":"publisher","unstructured":"Ribeiro, I. P. et al. Genetic imbalances detected by multiplex ligation-dependent probe amplification in a cohort of patients with oral squamous cell carcinoma-the first step towards clinical personalized medicine. Tumour Biol, https:\/\/doi.org\/10.1007\/s13277-014-1614-9 (2014).","DOI":"10.1007\/s13277-014-1614-9"},{"key":"14377_CR15","doi-asserted-by":"publisher","unstructured":"Ribeiro, I. P. et al. WT1, MSH6, GATA5 and PAX5 as epigenetic oral squamous cell carcinoma biomarkers - a short report Cellular Oncology, https:\/\/doi.org\/10.1007\/s13402-016-0293-5 (2016).","DOI":"10.1007\/s13402-016-0293-5"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-14377-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-14377-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-14377-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T12:34:52Z","timestamp":1671798892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-14377-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["14377"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-14377-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]},"assertion":[{"value":"28 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"13897"}}