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However, the role of LBDs in fruit ripening and in grapevine (<jats:italic>Vitis vinifera<\/jats:italic> L.) development and stress responses is poorly documented. By performing a model curation of <jats:italic>LBDs<\/jats:italic> in the latest genome annotation 50 genes were identified. Phylogenetic analysis showed that <jats:italic>LBD<\/jats:italic> genes can be grouped into two classes mapping on 16 out of the 19\u00a0<jats:italic>V. vinifera<\/jats:italic> chromosomes. New gene subclasses were identified that have not been characterized in other species. Segmental and tandem duplications contributed significantly to the expansion and evolution of the <jats:italic>LBD<\/jats:italic> gene family in grapevine as noticed for other species. The analysis of <jats:italic>cis<\/jats:italic>-regulatory elements and transcription factor binding sites in the <jats:italic>VviLBD<\/jats:italic> promoter regions suggests the involvement of several hormones in the regulation of <jats:italic>LBDs<\/jats:italic> expression. Expression profiling suggest the involvement of LBD transcription factors in grapevine development, berry ripening and stress responses. Altogether this study provides valuable information and robust candidate genes for future functional analysis aiming to clarify mechanisms responsible for the onset of fruit ripening and fruit defense strategies.<\/jats:p>","DOI":"10.1038\/s41598-017-16240-5","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T16:10:19Z","timestamp":1510762219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The LATERAL ORGAN BOUNDARIES Domain gene family in grapevine: genome-wide characterization and expression analyses during developmental processes and stress responses"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-4012","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Grimplet","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-0916","authenticated-orcid":false,"given":"Diana","family":"Pimentel","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Agudelo-Romero","sequence":"additional","affiliation":[]},{"given":"Jose Miguel","family":"Martinez-Zapater","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-0164","authenticated-orcid":false,"given":"Ana Margarida","family":"Fortes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"16240_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.tplants.2010.09.009","volume":"16","author":"C Majer","year":"2011","unstructured":"Majer, C. & Hochholdinger, F. 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