{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:30:11Z","timestamp":1768001411191,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24\u2009hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1\u03b1), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1\u03b1) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization. Thirty-eight women performed a resistance exercise session at an intensity of 60% (n\u2009=\u200913), 70% (n\u2009=\u200912) or 80% (n\u2009=\u200913) of one repetition maximum. Each session was comprised of three sets of 12 repetitions of four exercises: bench press, dumbbell curl, dumbbell squat, and standing dumbbell upright row. Blood was sampled at baseline and immediately, 6\u2009hours, and 24\u2009hours post-exercise. Circulating EPC and levels of VEGF, HIF-1\u03b1 and EPO were significantly higher after exercise (P\u2009&lt;\u20090.05). The change in EPCs from baseline was greatest in the 80% group (P\u2009&lt;\u20090.05), reaching the highest at 6\u2009hours post-exercise. The change in EPCs from baseline to 6\u2009hours post-exercise was correlated with the change in VEGF (r\u2009=\u20090.492, P\u2009=\u20090.002) and HIF-1\u03b1 (r\u2009=\u20090.388, P\u2009=\u20090.016). In general, a dose-response relationship was observed, with the highest exercise intensities promoting the highest increases in EPCs and angiogenic factors.<\/jats:p>","DOI":"10.1038\/s41598-017-18156-6","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T16:53:44Z","timestamp":1513184024000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Effects of resistance exercise on endothelial progenitor cell mobilization in women"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-1493","authenticated-orcid":false,"given":"Fernando","family":"Ribeiro","sequence":"first","affiliation":[]},{"given":"Ilda P.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-4802","authenticated-orcid":false,"given":"Ana C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Alberto J.","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Elsa","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Ana B.","family":"Sarmento-Ribeiro","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 A.","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Isabel M.","family":"Carreira","sequence":"additional","affiliation":[]},{"given":"Sarah","family":"Witkowski","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"18156_CR1","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1097\/PHM.0b013e31829b4c4f","volume":"92","author":"F Ribeiro","year":"2013","unstructured":"Ribeiro, F. et al. Effects of exercise training on endothelial progenitor cells in cardiovascular disease: a systematic review. Am J Phys Med Rehabil \n                           92, 1020\u20131030, https:\/\/doi.org\/10.1097\/PHM.0b013e31829b4c4f (2013).","journal-title":"Am J Phys Med Rehabil"},{"key":"18156_CR2","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/eurheartj\/ehp078","volume":"30","author":"AM Leone","year":"2009","unstructured":"Leone, A. M. et al. From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells. European heart journal \n                           30, 890\u2013899, https:\/\/doi.org\/10.1093\/eurheartj\/ehp078 (2009).","journal-title":"European heart journal"},{"key":"18156_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","volume":"95","author":"C Urbich","year":"2004","unstructured":"Urbich, C. & Dimmeler, S. Endothelial progenitor cells: characterization and role in vascular biology. Circulation research \n                           95, 343\u2013353, https:\/\/doi.org\/10.1161\/01.RES.0000137877.89448.78 (2004).","journal-title":"Circulation research"},{"key":"18156_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1152\/japplphysiol.01464.2010","volume":"111","author":"K Lenk","year":"2011","unstructured":"Lenk, K., Uhlemann, M., Schuler, G. & Adams, V. Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease. J Appl Physiol \n                           111, 321\u2013328, https:\/\/doi.org\/10.1152\/japplphysiol.01464.2010 (2011).","journal-title":"J Appl Physiol"},{"key":"18156_CR5","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1161\/hh1301.093953","volume":"89","author":"M Vasa","year":"2001","unstructured":"Vasa, M. et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circulation research \n                           89, E1\u20137 (2001).","journal-title":"Circulation research"},{"key":"18156_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1056\/NEJMoa022287","volume":"348","author":"JM Hill","year":"2003","unstructured":"Hill, J. M. et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. The New England journal of medicine \n                           348, 593\u2013600, https:\/\/doi.org\/10.1056\/NEJMoa022287 348\/7\/593 (2003).","journal-title":"The New England journal of medicine"},{"key":"18156_CR7","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1056\/NEJMoa043814","volume":"353","author":"N Werner","year":"2005","unstructured":"Werner, N. et al. Circulating endothelial progenitor cells and cardiovascular outcomes. The New England journal of medicine \n                           353, 999\u20131007, https:\/\/doi.org\/10.1056\/NEJMoa043814 (2005).","journal-title":"The New England journal of medicine"},{"key":"18156_CR8","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00392-012-0517-2","volume":"102","author":"KA Volaklis","year":"2013","unstructured":"Volaklis, K. A., Tokmakidis, S. P. & Halle, M. Acute and chronic effects of exercise on circulating endothelial progenitor cells in healthy and diseased patients. Clin Res Cardiol \n                           102, 249\u2013257, https:\/\/doi.org\/10.1007\/s00392-012-0517-2 (2013).","journal-title":"Clin Res Cardiol"},{"key":"18156_CR9","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1152\/japplphysiol.00532.2009","volume":"107","author":"S Mobius-Winkler","year":"2009","unstructured":"Mobius-Winkler, S. et al. Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals. 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