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Among the factors known to modulate adult hippocampal neurogenesis and brain function, lipocalin-2 (LCN2) was recently described as a key regulator of neural stem cells (NSCs) proliferation and commitment, with impact on several dimensions of behaviour. Herein, we evaluated whether voluntary running, a well-known regulator of cell genesis, rescue the deficient adult hippocampal neurogenesis observed in mice lacking LCN2. We observed that running, by counteracting oxidative stress in NSCs, reverses LCN2-null mice defective hippocampal neurogenesis, as it promotes NSCs cell cycle progression and maturation, resulting in a partial reduction in anxiety and improved contextual behaviour. Together, these findings demonstrate that running is a positive modulator of adult hippocampal neurogenesis and behaviour in mice lacking LCN2, by impacting on the antioxidant kinetics of NSCs.<\/jats:p>","DOI":"10.1038\/s41598-018-38140-y","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T11:05:41Z","timestamp":1549537541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Voluntary running rescues the defective hippocampal neurogenesis and behaviour observed in lipocalin 2-null mice"],"prefix":"10.1038","volume":"9","author":[{"given":"Ana Catarina","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Ashley","family":"Novais","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Carlos","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"38140_CR1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","volume":"70","author":"GL Ming","year":"2011","unstructured":"Ming, G. 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