{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:10:50Z","timestamp":1777907450781,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Mexico, HPV vaccines available immunize against genotypes 16\/18 and 16\/18\/6\/11; however, there is limited surveillance about carcinogenic subtypes in different states of the country that allow evaluating the effectiveness of vaccination and cervical cancer screening programs. Here, we report the regional and age-specific prevalence of 14 hr-HPV genotypes as well as their prevalence in abnormal cytology (from ASCUS to cervical cancer) among Mexican women which were undergoing from cervical cancer screening in the Salud Digna clinics in 20 states of the country. This study includes women with social security from the majority of public health institutions (IMSS, ISSSTE, SEMAR, and PEMEX), and women without social security. For cervical cancer screening, we used the SurePath liquid-based cytology and the BD Onclarity HPV Assay. From December 1, 2016, to August 2, 2018, the hr-HPV prevalence among 60,135 women was 24.78%, the most prevalent types were HPV 16 (4.13%), HPV 31 (4.12%) and HPV 51 (3.39%), while HPV 18 (1.70%) was less prevalent among infected women. Interestingly, the genotypes not covered by current vaccines in Mexico were commonly found in precancerous lesions, evidencing their carcinogenic potential, so it is necessary to increase their surveillance and inclusion in cervical cancer screening triage.<\/jats:p>","DOI":"10.1038\/s41598-019-46543-8","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T10:03:41Z","timestamp":1562925821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The burden of 14 hr-HPV genotypes in women attending routine cervical cancer screening in 20 states of Mexico: a cross-sectional study"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-9528","authenticated-orcid":false,"given":"Abraham","family":"Campos-Romero","sequence":"first","affiliation":[]},{"given":"Karen S.","family":"Anderson","sequence":"additional","affiliation":[]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[]},{"given":"Marco A.","family":"Luna-Ruiz Esparza","sequence":"additional","affiliation":[]},{"given":"David J.","family":"Mor\u00e1n-Portela","sequence":"additional","affiliation":[]},{"given":"Javier A.","family":"Castro-Men\u00e9ndez","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 L.","family":"Moreno-Camacho","sequence":"additional","affiliation":[]},{"given":"Diana Y.","family":"Calva-Espinosa","sequence":"additional","affiliation":[]},{"given":"Manuel A.","family":"Acosta-Alfaro","sequence":"additional","affiliation":[]},{"given":"Freddy A.","family":"Meynard-Mej\u00eda","sequence":"additional","affiliation":[]},{"given":"Marlene","family":"Mu\u00f1oz-Gait\u00e1n","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-4223","authenticated-orcid":false,"given":"Jonathan","family":"Alc\u00e1ntar-Fern\u00e1ndez","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"46543_CR1","unstructured":"Bruni L. et al. Human Papillomavirus and Related Diseases in the World. (ICO Information Centre on HPV and Cancer (HPV Information Centre), 2017)."},{"key":"46543_CR2","doi-asserted-by":"publisher","first-page":"e20183","DOI":"10.1371\/journal.pone.0020183","volume":"6","author":"Z Chen","year":"2011","unstructured":"Chen, Z. et al. Evolution and Taxonomic Classification of Human Papillomavirus 16 (HPV16)-Related Variant Genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. PLoS One 6, e20183 (2011).","journal-title":"PLoS One"},{"key":"46543_CR3","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.virol.2013.07.018","volume":"445","author":"RD Burk","year":"2013","unstructured":"Burk, R. D., Harari, A. & Chen, Z. Human papillomavirus genome variants. Virology 445, 232\u2013243 (2013).","journal-title":"Virology"},{"key":"46543_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep05807","volume":"4","author":"D Bzhalava","year":"2014","unstructured":"Bzhalava, D. et al. Deep sequencing extends the diversity of human papillomaviruses in human skin. Sci. Rep. 4, 1\u20137 (2014).","journal-title":"Sci. Rep."},{"key":"46543_CR5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/sj.bjc.6602915","volume":"94","author":"S Bulk","year":"2006","unstructured":"Bulk, S. et al. Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands. Br. J. Cancer 94, 171\u2013175 (2006).","journal-title":"Br. J. Cancer"},{"key":"46543_CR6","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1002\/ijc.23282","volume":"122","author":"G Clifford","year":"2008","unstructured":"Clifford, G. & Franceschi, S. Members of the human papillomavirus type 18 family (alpha-7 species) share a common association with adenocarcinoma of the cervix. Int. J. Cancer 122, 1684\u20131685 (2008).","journal-title":"Int. J. Cancer"},{"key":"46543_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23947-6","volume":"8","author":"Y Ueda","year":"2018","unstructured":"Ueda, Y. et al. Dynamic changes in Japan\u2019s prevalence of abnormal findings in cervical cervical cytology depending on birth year. Sci. Rep. 8, 5612 (2018).","journal-title":"Sci. Rep."},{"key":"46543_CR8","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1158\/1055-9965.EPI-07-2659","volume":"17","author":"E Lazcano-Ponce","year":"2008","unstructured":"Lazcano-Ponce, E. et al. Decreasing cervical cancer mortality in Mexico: Effect of papanicolaou coverage, birthrate, and the importance of diagnostic validity of cytology. Cancer Epidemiol. Biomarkers Prev. 17, 2808\u20132817 (2008).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"46543_CR9","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/bjc.2016.290","volume":"115","author":"R Landy","year":"2016","unstructured":"Landy, R., Pesola, F., Casta\u00f1\u00f3n, A. & Sasieni, P. Impact of cervical screening on cervical cancer mortality: Estimation using stage-specific results from a nested case-control study. Br. J. Cancer 115, 1140\u20131146 (2016).","journal-title":"Br. J. Cancer"},{"key":"46543_CR10","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1086\/657321","volume":"202","author":"L Bruni","year":"2010","unstructured":"Bruni, L. et al. Cervical Human Papillomavirus Prevalence in 5 Continents: Meta-Analysis of 1 Million Women with Normal Cytological Findings. J. Infect. Dis. 202, 1789\u20131799 (2010).","journal-title":"J. Infect. Dis."},{"key":"46543_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/ijc.28639","volume":"135","author":"E Lazcano-Ponce","year":"2014","unstructured":"Lazcano-Ponce, E. et al. Specimen self-collection and HPV DNA screening in a pilot study of 100,242 women. Int. J. Cancer 135, 109\u2013116 (2014).","journal-title":"Int. J. Cancer"},{"key":"46543_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.21149\/spm.v58i2.7789","volume":"58","author":"L Torres-Ibarra","year":"2016","unstructured":"Torres-Ibarra, L. et al. Triage strategies in cervical cancer detection in Mexico: methods of the FRIDA Study. Salud Publica Mex. 58, 197\u2013210 (2016).","journal-title":"Salud Publica Mex."},{"key":"46543_CR13","unstructured":"Programa de vacunaci\u00f3n universal - lineamientos 2014. Available at, http:\/\/www.censia.salud.gob.mx\/contenidos\/descargas\/vacunas\/LINEPVU2014SF.pdf (2014)."},{"key":"46543_CR14","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1002\/ijc.27485","volume":"131","author":"P Guan","year":"2012","unstructured":"Guan, P. et al. Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer. Int. J. Cancer 131, 2349\u20132359 (2012).","journal-title":"Int. J. Cancer"},{"key":"46543_CR15","first-page":"14","volume":"6","author":"MA Pourhoseingholi","year":"2013","unstructured":"Pourhoseingholi, M. A., Vahedi, M. & Rahimzadeh, M. Sample size calculation in medical studies. Gastroenterol. Hepatol. from Bed to Bench 6, 14\u201317 (2013).","journal-title":"Gastroenterol. Hepatol. from Bed to Bench"},{"key":"46543_CR16","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1590\/S0036-36342003000900013","volume":"45","author":"Yvonne Flores","year":"2003","unstructured":"Flores, Y. et al. Improving cervical cancer screening in Mexico: Results from the Morelos HPV Study. Salud Publica Mex. 45, Suppl 3:S388\u201398\u00a0(2003).","journal-title":"Salud P\u00fablica de M\u00e9xico"},{"key":"46543_CR17","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/1097-0215(20010201)91:3<412::AID-IJC1071>3.0.CO;2-M","volume":"9","author":"E Lazcano-Ponce","year":"2001","unstructured":"Lazcano-Ponce, E. et al. Epidemiology of HPV infection among Mexican women with normal cervical cytology. Int J Cancer 9, 412\u2013420 (2001).","journal-title":"Int J Cancer"},{"key":"46543_CR18","unstructured":"Ritu, N. & Wilbur, D. C. The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. (Springer, 2015)."},{"key":"46543_CR19","first-page":"569","volume":"85","author":"DY Calva-Espinosa","year":"2017","unstructured":"Calva-Espinosa, D. Y. et al. Comparison of automated\u00a0platforms for the HPV genotypification. Ginecol. Obstet. Mex. 85, 569\u2013577 (2017).","journal-title":"Ginecol. Obstet. Mex."},{"key":"46543_CR20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/1743-422X-9-262","volume":"9","author":"ALP Abreu","year":"2012","unstructured":"Abreu, A. L. P., Souza, R. P., Gimenes, F. & Consolaro, M. E. L. A review of methods for detect human Papillomavirus infection. Virol. J. 9, 262 (2012).","journal-title":"Virol. J."},{"key":"46543_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ejogrb.2013.06.027","volume":"170","author":"WAA Tjalma","year":"2013","unstructured":"Tjalma, W. A. A. & Depuydt, C. E. Cervical cancer screening: Which HPV test should be used - L1 or E6\/E7? Eur. J. Obstet. Gynecol. Reprod. Biol. 170, 45\u201346 (2013).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"46543_CR22","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.ygyno.2018.04.007","volume":"149","author":"MH Stoler","year":"2018","unstructured":"Stoler, M. H. et al. The Onclarity Human Papillomavirus Trial: Design, methods, and baseline results. Gynecol. Oncol. 149, 498\u2013505 (2018).","journal-title":"Gynecol. Oncol."},{"key":"46543_CR23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","volume":"10","author":"V Bouvard","year":"2009","unstructured":"Bouvard, V. et al. A review of human carcinogens\u2014Part B: biological agents. Lancet Oncol. 10, 321\u2013322 (2009).","journal-title":"Lancet Oncol."},{"key":"46543_CR24","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/ijc.25396","volume":"128","author":"N Li","year":"2011","unstructured":"Li, N., Franceschi, S., Howell-Jones, R., Snijders, P. J. F. & Clifford, G. M. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication. Int. J. Cancer 128, 927\u2013935 (2011).","journal-title":"Int. J. Cancer"},{"key":"46543_CR25","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1582-4934.2007.00073.x","volume":"11","author":"CE Depuydt","year":"2007","unstructured":"Depuydt, C. E. et al. Comparison of MY09\/11 consensus PCR and type-specific PCRs in the detection of oncogenic HPV types. J. Cell. Mol. Med. 11, 881\u2013891 (2007).","journal-title":"J. Cell. Mol. Med."},{"key":"46543_CR26","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/jcm.35.6.1304-1310.1997","volume":"35","author":"W Qu","year":"1997","unstructured":"Qu, W. et al. PCR detection of human papillomavirus: Comparison between MY09\/MY11 and GP5+\/GP6+ primer systems. J. Clin. Microbiol. 35, 1304\u20131310 (1997).","journal-title":"J. Clin. Microbiol."},{"key":"46543_CR27","first-page":"262","volume":"69","author":"I J\u00e1come-Galarza","year":"2017","unstructured":"J\u00e1come-Galarza, I. et al. Prevalence of human papillomavirus in women from the state of Michoacan, Mexico, Showed high frequency of unusual virus genotypes. Rev. Investig. Clin. 69, 262\u2013269 (2017).","journal-title":"Rev. Investig. Clin."},{"key":"46543_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.clinthera.2013.11.009","volume":"36","author":"GB Lazenby","year":"2014","unstructured":"Lazenby, G. B. et al. An association between trichomonas vaginalis and high-risk human papillomavirus in rural tanzanian women undergoing cervical cancer screening. Clin. Ther. 36, 38\u201345 (2014).","journal-title":"Clin. Ther."},{"key":"46543_CR29","first-page":"XE01","volume":"10","author":"I Ghosh","year":"2016","unstructured":"Ghosh, I., Mandal, R., Kundu, P. & Biswas, J. Association of genital infections other than human papillomavirus with pre-invasive and invasive cervical Neoplasia. J. Clin. Diagnostic Res. 10, XE01\u2013XE06 (2016).","journal-title":"J. Clin. Diagnostic Res."},{"key":"46543_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2334-9-16","volume":"9","author":"R Verteramo","year":"2009","unstructured":"Verteramo, R. et al. Human Papillomaviruses and genital co-infections in gynaecological outpatients. BMC Infect. Dis. 9, 1\u20137 (2009).","journal-title":"BMC Infect. Dis."},{"key":"46543_CR31","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/jhg.2012.17","volume":"57","author":"M Guardado-Estrada","year":"2012","unstructured":"Guardado-Estrada, M. et al. The amerindian mtDNA haplogroup B2 enhances the risk of HPV for cervical cancer: De-regulation of mitochondrial genes may be involved. J. Hum. Genet. 57, 269\u2013276 (2012).","journal-title":"J. Hum. Genet."},{"key":"46543_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0190966","volume":"13","author":"I Badano","year":"2018","unstructured":"Badano, I. et al. Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina. PLoS One 13, 1\u201316 (2018).","journal-title":"PLoS One"},{"key":"46543_CR33","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.arcmed.2011.07.002","volume":"42","author":"C Alaez-Verson","year":"2011","unstructured":"Alaez-Verson, C. et al. HPV-16 and HLA-DRB1 Alleles Are Associated with Cervical Carcinoma in Mexican Mestizo Women. Arch. Med. Res. 42, 421\u2013425 (2011).","journal-title":"Arch. Med. Res."},{"issue":"10","key":"46543_CR34","doi-asserted-by":"publisher","first-page":"e109406","DOI":"10.1371\/journal.pone.0109406","volume":"9","author":"Mariano Guardado-Estrada","year":"2014","unstructured":"Guardado-Estrada, M. et al. The distribution of high-risk human papillomaviruses is different in young and old patients with cervical cancer. PLoS One 9 (2014).","journal-title":"PLoS ONE"},{"key":"46543_CR35","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1002\/jmv.24099","volume":"87","author":"A Aguilar-Lemarroy","year":"2015","unstructured":"Aguilar-Lemarroy, A. et al. Human papillomavirus infections in Mexican Women with normal cytology, precancerous lesions, and cervical cancer: Type-specific prevalence and HPV coinfections. J. Med. Virol. 87, 871\u2013884 (2015).","journal-title":"J. Med. Virol."},{"key":"46543_CR36","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ygyno.2010.01.036","volume":"117","author":"B Illades-Aguiar","year":"2010","unstructured":"Illades-Aguiar, B. et al. Prevalence and distribution of human papillomavirus types in cervical cancer, squamous intraepithelial lesions, and with no intraepithelial lesions in women from Southern Mexico. Gynecol. Oncol. 117, 291\u2013296 (2010).","journal-title":"Gynecol. Oncol."},{"key":"46543_CR37","doi-asserted-by":"publisher","first-page":"8689","DOI":"10.7314\/APJCP.2014.15.20.8689","volume":"15","author":"M Anaya-Ruiz","year":"2014","unstructured":"Anaya-Ruiz, M., Vincent, A. K. & Perez-Santos, M. Cervical cancer trends in Mexico: Incidence, mortality and research output. Asian Pacific J. Cancer Prev. 15, 8689\u20138692 (2014).","journal-title":"Asian Pacific J. Cancer Prev."},{"key":"46543_CR38","doi-asserted-by":"publisher","first-page":"10061","DOI":"10.7314\/APJCP.2014.15.23.10061","volume":"15","author":"M Salcedo","year":"2014","unstructured":"Salcedo, M. et al. Human papillomavirus genotypes among females in Mexico: A study from the Mexican Institute for Social Security. Asian Pacific J. Cancer Prev. 15, 10061\u201310066 (2014).","journal-title":"Asian Pacific J. Cancer Prev."},{"key":"46543_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0025493","volume":"6","author":"A Ciapponi","year":"2011","unstructured":"Ciapponi, A., Bardach, A., Glujovsky, D., Gibbons, L. & Picconi, M. A. Type-specific HPV prevalence in cervical cancer and high-grade lesions in Latin America and the Caribbean: Systematic review and meta-analysis. PLoS One 6, 1\u201315 (2011).","journal-title":"PLoS One"},{"key":"46543_CR40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1309\/AJCP53KMHNRDICBL","volume":"142","author":"C Wright Thomas","year":"2014","unstructured":"Wright Thomas, C. et al. Clinical performance of the BD onclarity HPV assay using an adjudicated cohort of BD surepath liquid-based cytology specimens. Am. J. Clin. Pathol. 142, 43\u201350 (2014).","journal-title":"Am. J. Clin. Pathol."},{"key":"46543_CR41","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1016\/S0140-6736(17)31821-4","volume":"390","author":"WK Huh","year":"2017","unstructured":"Huh, W. K. et al. Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16\u201326 years: a randomised, double-blind trial. Lancet 390, 2143\u20132159 (2017).","journal-title":"Lancet"},{"key":"46543_CR42","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1017\/S0950268817000747","volume":"145","author":"C Signorelli","year":"2017","unstructured":"Signorelli, C. et al. Human papillomavirus 9-valent vaccine for cancer prevention: A systematic review of the available evidence. Epidemiol. Infect. 145, 1962\u20131982 (2017).","journal-title":"Epidemiol. Infect."},{"key":"46543_CR43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.pvr.2017.12.004","volume":"5","author":"\u00c1M Ruiz-Sternberg","year":"2017","unstructured":"Ruiz-Sternberg, \u00c1. M. et al. Efficacy, immunogenicity, and safety of a 9-valent human papillomavirus vaccine in Latin American girls, boys, and young women. Papillomavirus Res. 5, 63\u201374 (2017).","journal-title":"Papillomavirus Res."},{"key":"46543_CR44","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.1016\/j.vaccine.2016.07.035","volume":"34","author":"P Van Damme","year":"2016","unstructured":"Van Damme, P. et al. Use of the nonavalent HPV vaccine in individuals previously fully or partially vaccinated with bivalent or quadrivalent HPV vaccines. Vaccine 34, 4759\u20134760 (2016).","journal-title":"Vaccine"},{"key":"46543_CR45","doi-asserted-by":"publisher","first-page":"184.e1","DOI":"10.1016\/j.ajog.2012.11.020","volume":"208","author":"JT Cox","year":"2013","unstructured":"Cox, J. T. et al. Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16\/18: Results from the ATHENA HPV study. Am. J. Obstet. Gynecol. 208, 184.e1\u2013184.e11 (2013).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"46543_CR46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jcv.2015.11.015","volume":"76","author":"N Wentzensen","year":"2016","unstructured":"Wentzensen, N., Schiffman, M., Palmer, T. & Arbyn, M. Triage of HPV positive women in cervical cancer screening. J. Clin. Virol. 76, 49\u201355 (2016).","journal-title":"J. Clin. Virol."},{"issue":"2","key":"46543_CR47","doi-asserted-by":"publisher","first-page":"e96","DOI":"10.1016\/S2468-2667(17)30007-5","volume":"2","author":"Jie-Bin Lew","year":"2017","unstructured":"Lew, J. et al. Primary HPV testing versus cytology-based cervical screening in women in Australia vaccinated for HPV and unvaccinated: eff ectiveness and economic assessment for the National Cervical Screening Program. 96\u2013107, https:\/\/doi.org\/10.1016\/S2468-2667(17)30007-5 (2017).","journal-title":"The Lancet Public Health"},{"key":"46543_CR48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1001\/jama.2018.7464","volume":"320","author":"GS Ogilvie","year":"2018","unstructured":"Ogilvie, G. S. et al. Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months The HPV FOCAL Randomized Clinical Trial. JAMA 320, 43\u201352 (2018).","journal-title":"JAMA"},{"key":"46543_CR49","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1002\/ijc.30090","volume":"139","author":"RMF Ebisch","year":"2016","unstructured":"Ebisch, R. M. F. et al. The clinical value of HPV genotyping in triage of women with high-risk-HPV-positive self-samples. Int. J. Cancer 139, 691\u2013699 (2016).","journal-title":"Int. J. Cancer"},{"key":"46543_CR50","doi-asserted-by":"crossref","unstructured":"Beal, C. M. et al. Cost analysis of different cervical cancer screening strategies in Mexico. 56 (2014).","DOI":"10.21149\/spm.v56i5.7374"},{"key":"46543_CR51","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pvr.2016.05.004","volume":"2","author":"C Jack","year":"2016","unstructured":"Jack, C. & Cosette, W. Need for expanded HPV genotyping for cervical screening. Papillomavirus Res. 2, 112\u2013115 (2016).","journal-title":"Papillomavirus Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46543-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:31:33Z","timestamp":1695018693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-019-46543-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,12]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["46543"],"URL":"https:\/\/doi.org\/10.1038\/s41598-019-46543-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,12]]},"assertion":[{"value":"7 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"10094"}}