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For this purpose, a physics inspired weight map that takes the user input into account is proposed, which is used both as a feature map and in the system\u2019s loss function. Our approach is extensively evaluated on the public LIDC-IDRI dataset, where we achieve a state-of-the-art performance of 0.55 intersection over union vs the 0.59 inter-observer agreement. Also, we show that iW-Net allows to correct the segmentation of small nodules, essential for proper patient referral decision, as well as improve the segmentation of the challenging non-solid nodules and thus may be an important tool for increasing the early diagnosis of lung cancer.<\/jats:p>","DOI":"10.1038\/s41598-019-48004-8","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T10:03:02Z","timestamp":1565604182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["iW-Net: an automatic and minimalistic interactive lung nodule segmentation deep network"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-2156","authenticated-orcid":false,"given":"Guilherme","family":"Aresta","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1180-3805","authenticated-orcid":false,"given":"Colin","family":"Jacobs","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Ramos","sequence":"additional","affiliation":[]},{"given":"Bram","family":"van Ginneken","sequence":"additional","affiliation":[]},{"given":"Aur\u00e9lio","family":"Campilho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"48004_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel, R. 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