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AMP surface grafting onto biomaterials has been described as a good strategy to overcome problems associated with their <jats:italic>in vivo<\/jats:italic> stability. <jats:italic>Helicobacter pylori<\/jats:italic> is among the bacteria that pose greatest threat to human health, being MSI-78A one of the few bactericidal AMPs against this bacterium. Here, we report that MSI-78A grafted onto model surfaces (Self-Assembled Monolayers \u2013SAMs), in a concentration of 30.3\u2009\u00b1\u20091.2\u2009ng\/cm<jats:sup>2<\/jats:sup> determined by quartz crystal microbalance with dissipation (QCM-D), was able to kill, by contact, 98% of planktonic <jats:italic>H. pylori<\/jats:italic> in only 2\u2009h. This fact was not verified against the control bacteria (<jats:italic>Staphylococcus epidermidis<\/jats:italic>), although the minimal inhibitory concentration (MIC) of MSI-78A in solution is much lower for <jats:italic>S. epidermidis<\/jats:italic> (2 \u03bcg\/mL) than for <jats:italic>H. pylori<\/jats:italic> (64 \u03bcg\/mL). Our results also demonstrated that, in opposite to other bacteria, <jats:italic>H. pylori<\/jats:italic> cells were attracted to ethylene glycol terminated (antiadhesive) surfaces, which can explain the high bactericidal potential of grafted MSI-78A. This proof of concept study establishes the foundations for development of MSI-78A grafted nanoparticles for gastric infection management within a targeted nanomedicine concept.<\/jats:p>","DOI":"10.1038\/s41598-019-53918-4","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T11:04:18Z","timestamp":1575371058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management"],"prefix":"10.1038","volume":"9","author":[{"given":"Paula","family":"Parreira","sequence":"first","affiliation":[]},{"given":"Claudia","family":"Monteiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-7651","authenticated-orcid":false,"given":"Vanessa","family":"Gra\u00e7a","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Maia","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"In\u00eas C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-4794","authenticated-orcid":false,"given":"M. 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