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Fungal infections treatment faces three major challenges: the limited number of therapeutic options, the toxicity of the available drugs, and the rise of antifungal resistance. In this study, we demonstrate the antifungal activity and mechanism of action of peptides ToAP2 and NDBP-5.7 against planktonic cells and biofilms of <jats:italic>C. albicans<\/jats:italic>. Both peptides were active against <jats:italic>C. albicans<\/jats:italic> cells; however, ToAP2 was more active and produced more pronounced effects on fungal cells. Both peptides affected <jats:italic>C. albicans<\/jats:italic> membrane permeability and produced changes in fungal cell morphology, such as deformations in the cell wall and disruption of ultracellular organization. Both peptides showed synergism with amphotericin B, while ToAP2 also presents a synergic effect with fluconazole. Besides, ToAP2 (6.25\u2009\u00b5M.) was able to inhibit filamentation after 24\u2009h of treatment and was active against both the early phase and mature biofilms of <jats:italic>C. albicans<\/jats:italic>. Finally, ToAP2 was protective in a <jats:italic>Galleria mellonella<\/jats:italic> model of infection. Altogether these results point to the therapeutic potential of ToAP2 and other antimicrobial peptides in the development of new therapies for <jats:italic>C. albicans<\/jats:italic> infections.<\/jats:p>","DOI":"10.1038\/s41598-020-67041-2","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T10:03:02Z","timestamp":1593079382000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells"],"prefix":"10.1038","volume":"10","author":[{"given":"Jhones","family":"do Nascimento Dias","sequence":"first","affiliation":[]},{"given":"Calliandra","family":"de Souza Silva","sequence":"additional","affiliation":[]},{"given":"Alyne Rodrigues","family":"de Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Jessica Maria Teles","family":"Souza","sequence":"additional","affiliation":[]},{"given":"Paulo Henrique","family":"de Holanda Veloso J\u00fanior","sequence":"additional","affiliation":[]},{"given":"Wanessa Felix","family":"Cabral","sequence":"additional","affiliation":[]},{"given":"Maria","family":"da Gl\u00f3ria da Silva","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Eaton","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Roberto","family":"de Souza de Almeida Leite","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9 Moraes","family":"Nicola","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia","family":"Albuquerque","sequence":"additional","affiliation":[]},{"given":"Ildinete","family":"Silva-Pereira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"67041_CR1","doi-asserted-by":"publisher","first-page":"ftw018","DOI":"10.1093\/femspd\/ftw018","volume":"74","author":"C Tsui","year":"2016","unstructured":"Tsui, C., Kong, E. 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