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This exploratory study examines the relationships among genital responses, brain responses, and eye movements, to disentangle the role played by the anterior and posterior insula during different stages of male sexual response and during visual attention to sexual stimuli. In 19 healthy men, fMRI, eye movement, and penile tumescence data were collected during a visual sexual stimulation task. After a whole-brain analysis comparing neutral and sexual clips and confirming a role for the bilateral insulae, we selected two bilateral seed regions in anterior and posterior insula for functional connectivity analysis. Single-ROI-GLMs were run for the FC target regions. Single-ROI-GLMs were performed based on areas to which participants fixate: \u201cFaces\u201d, \u201cGenitals,\u201d and \u201cBackground\u201d with the contrast \u201cGenitals\u2009&gt;\u2009Faces\u201d. Single-ROI-GLMs with baseline, onset, and sustained PT response for the sexual clips were performed. We found stronger effects for the posterior than the anterior insula. In the target regions of the posterior insula, we found three different pathways: the first involved in visual attention, onset of erection, and sustained erection; the second involved only in the onset of erection, and the third limited to sustained erection.<\/jats:p>","DOI":"10.1038\/s41598-020-74681-x","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:24:39Z","timestamp":1603884279000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The role of anterior and posterior insula in male genital response and in visual attention: an exploratory multimodal fMRI study"],"prefix":"10.1038","volume":"10","author":[{"given":"Nicoletta","family":"Cera","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o","family":"Castelhano","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Ana Lu\u00edsa","family":"Quinta Gomes","sequence":"additional","affiliation":[]},{"given":"Maria Manuela","family":"Peixoto","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Erick","family":"Janssen","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Nobre","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"issue":"6","key":"74681_CR1","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/S0090-4295(01)00992-X","volume":"57","author":"K Park","year":"2001","unstructured":"Park, K. et al. 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