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We investigated the effect of <jats:italic>hoxd13a <\/jats:italic>overexpression on putative downstream targets and found it to cause downregulation of proximal fin identity markers (<jats:italic>meis1<\/jats:italic> and <jats:italic>emx2<\/jats:italic>) and upregulation of genes involved in skeletogenesis\/patterning (<jats:italic>fbn1<\/jats:italic>, <jats:italic>dacha<\/jats:italic>) and AER\/Finfold maintenance (<jats:italic>bmps<\/jats:italic>). We then show that <jats:italic>bmp2b<\/jats:italic> overexpression leads to finfold reduction, recapitulating the phenotype observed in <jats:italic>hoxd13a<\/jats:italic>-overexpressing fins. In addition, we show that during the development of the long finfold in leo<jats:sup>t1<\/jats:sup>\/lof<jats:sup>dt1<\/jats:sup> mutants, <jats:italic>hoxd13a<\/jats:italic> and <jats:italic>bmp2b<\/jats:italic> are downregulated. Our results suggest that modulation of the transcription factor\u00a0Hoxd13 during evolution may have been involved in finfold reduction through regulation of the\u00a0Bmp signalling that then activated apoptotic mechanisms impairing finfold elongation.<\/jats:p>","DOI":"10.1038\/s41598-021-86621-4","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T10:03:41Z","timestamp":1617098621000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hoxd13\/Bmp2-mediated mechanism involved in zebrafish finfold design"],"prefix":"10.1038","volume":"11","author":[{"given":"Jo\u00e3o","family":"Castro","sequence":"first","affiliation":[]},{"given":"Vanessa","family":"Beviano","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Pa\u00e7o","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Leit\u00e3o-Castro","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Cadete","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Francisco","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0123-7232","authenticated-orcid":false,"given":"Renata","family":"Freitas","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"issue":"3","key":"86621_CR1","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1073\/pnas.1915983117","volume":"117","author":"TA Stewart","year":"2020","unstructured":"Stewart, T. 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