{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:51:27Z","timestamp":1770907887200,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/138499\/2018"],"award-info":[{"award-number":["SFRH\/BD\/138499\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to quantify and assess the relationship of young soccer players' off-training physical activity (PA) and training responses on sleep quality. Eleven adolescent soccer players (13\u2009\u00b1\u20090.5\u00a0years old) were monitored during weekdays for four consecutive weeks, throughout soccer practice days. Off-training PA and sleep quality were assessed using 100\u00a0Hz tri-axial accelerometers and training responses analyzed using 20\u00a0Hz global positioning measurement units. A cluster analysis classified all cases into three different dimensions, (1) off-training PA, (2) training responses and (3) sleep quality. For each dimension, the most important variables for classifying the cases into clusters were sedentary PA and moderate-to-vigorous PA; total distance covered and impacts; and sleep onset latency and sleep fragmentation index, respectively. Afterwards, a correspondence analysis was used to identify whether off-training PA and training responses affected sleep quality. Results exposed that high to medium off-training PA combined with medium to high training responses may have decreased sleep quality. Conversely, no correspondence was observed between off-training PA and training responses, with higher sleep quality. This study emphasizes the importance of sports organizations adopting a holistic approach to youth soccer players\u2019 development, that appropriately considers the inter-relationship between lifestyle, performance and health-related information.<\/jats:p>","DOI":"10.1038\/s41598-021-89693-4","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T10:04:23Z","timestamp":1620900263000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Off-training physical activity and training responses as determinants of sleep quality in young soccer players"],"prefix":"10.1038","volume":"11","author":[{"given":"Nuno","family":"Mateus","sequence":"first","affiliation":[]},{"given":"Juliana","family":"Exel","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Anthony","family":"Weldon","sequence":"additional","affiliation":[]},{"given":"Jaime","family":"Sampaio","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"89693_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S2352-4642(19)30323-2","volume":"4","author":"R Guthold","year":"2020","unstructured":"Guthold, R., Stevens, G. A., Riley, L. M. & Bull, F. C. Global trends in insufficient physical activity among adolescents: A pooled analysis of 298 population-based surveys with 1.6 million participants. Lancet Child Adolesc. Health 4, 23\u201335 (2020).","journal-title":"Lancet Child Adolesc. Health"},{"key":"89693_CR2","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0140-6736(12)60898-8","volume":"380","author":"HW Kohl 3rd","year":"2012","unstructured":"Kohl, H. W. 3rd. et al. The pandemic of physical inactivity: Global action for public health. Lancet 380, 294\u2013305 (2012).","journal-title":"Lancet"},{"key":"89693_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00448","author":"P Izzicupo","year":"2019","unstructured":"Izzicupo, P. et al. Can off-training physical behaviors influence recovery in athletes? A scoping review. Front. Physiol. https:\/\/doi.org\/10.3389\/fphys.2019.00448 (2019).","journal-title":"Front. Physiol."},{"key":"89693_CR4","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3389\/fphys.2017.00655","volume":"8","author":"B Sperlich","year":"2017","unstructured":"Sperlich, B. et al. Sedentary behavior among national elite rowers during off-training\u2014A pilot study. Front. Physiol. 8, 655 (2017).","journal-title":"Front. Physiol."},{"key":"89693_CR5","doi-asserted-by":"publisher","first-page":"e000023","DOI":"10.1136\/bmjsem-2015-000023","volume":"1","author":"R Weiler","year":"2015","unstructured":"Weiler, R., Aggio, D., Hamer, M., Taylor, T. & Kumar, B. Sedentary behaviour among elite professional footballers: Health and performance implications. BMJ Open Sport Exerc. Med. 1, e000023 (2015).","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"89693_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3390\/sports6040141","volume":"6","author":"J Exel","year":"2018","unstructured":"Exel, J. et al. Off-training levels of physical activity and sedentary behavior in young athletes: Preliminary results during a typical week. Sports 6, 141 (2018).","journal-title":"Sports"},{"key":"89693_CR7","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1080\/02640414.2017.1420452","volume":"36","author":"T Rantalainen","year":"2018","unstructured":"Rantalainen, T., Pesola, A. J., Quittner, M., Ridgers, N. D. & Belavy, D. L. Are habitual runners physically inactive?. J. Sports Sci. 36, 1793\u20131800 (2018).","journal-title":"J. Sports Sci."},{"key":"89693_CR8","first-page":"181","volume":"15","author":"N Mateus","year":"2019","unstructured":"Mateus, N., Gon\u00e7alves, B., Exel, J. & Sampaio, J. The relationship between sedentary behaviour, physical activity and sports performance among adolescents. Motricidade 15, 181\u2013181 (2019).","journal-title":"Motricidade"},{"key":"89693_CR9","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s12529-016-9609-0","volume":"24","author":"Y Yang","year":"2017","unstructured":"Yang, Y., Shin, J. C., Li, D. & An, R. Sedentary behavior and sleep problems: A systematic review and meta-analysis. Int. J. Behav. Med. 24, 481\u2013492 (2017).","journal-title":"Int. J. Behav. Med."},{"key":"89693_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/17477160903067601","volume":"5","author":"D Jim\u00e9nez-Pav\u00f3n","year":"2010","unstructured":"Jim\u00e9nez-Pav\u00f3n, D., Kelly, J. & Reilly, J. J. Associations between objectively measured habitual physical activity and adiposity in children and adolescents: Systematic review. Int. J. Pediatr. Obes. 5, 3\u201318. https:\/\/doi.org\/10.3109\/17477160903067601 (2010).","journal-title":"Int. J. Pediatr. Obes."},{"key":"89693_CR11","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3945\/ajcn.116.150540","volume":"105","author":"T Skrede","year":"2017","unstructured":"Skrede, T. et al. Moderate-to-vigorous physical activity, but not sedentary time, predicts changes in cardiometabolic risk factors in 10-y-old children: The Active Smarter Kids Study. Am. J. Clin. Nutr. 105, 1391\u20131398 (2017).","journal-title":"Am. J. Clin. Nutr."},{"key":"89693_CR12","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s40279-019-01089-7","volume":"49","author":"JJ Smith","year":"2019","unstructured":"Smith, J. J. et al. Behavioral correlates of muscular fitness in children and adolescents: A systematic review. Sports Med. 49, 887\u2013904 (2019).","journal-title":"Sports Med."},{"key":"89693_CR13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/24733938.2018.1562276","volume":"3","author":"A Ala-Kitula","year":"2019","unstructured":"Ala-Kitula, A., Peltonen, J., Finni, T. & Linnamo, V. Physical activity on days with and without soccer practice in 12\u201313-year-old boys. Sci. Med. Footb. 3, 245\u2013250 (2019).","journal-title":"Sci. Med. Footb."},{"key":"89693_CR14","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1123\/ijspp.2013-0120","volume":"9","author":"EA Abade","year":"2014","unstructured":"Abade, E. A., Gon\u00e7alves, B. V., Leite, N. M. & Sampaio, J. E. Time\u2013motion and physiological profile of football training sessions performed by under-15, under-17, and under-19 elite Portuguese players. Int. J. Sports Physiol. Perform. 9, 463\u2013470 (2014).","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"89693_CR15","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1080\/02640414.2015.1022575","volume":"33","author":"D Coutinho","year":"2015","unstructured":"Coutinho, D. et al. Typical weekly workload of under 15, under 17, and under 19 elite Portuguese football players. J. Sports Sci. 33, 1229\u20131237 (2015).","journal-title":"J. Sports Sci."},{"key":"89693_CR16","doi-asserted-by":"publisher","first-page":"e000178","DOI":"10.1136\/bmjsem-2016-000178","volume":"2","author":"SA S\u00e6ther","year":"2017","unstructured":"S\u00e6ther, S. A. & Aspvik, N. P. Descriptive analysis of objectively assessed physical activity among talented soccer players: A study of three Norwegian professional football clubs. BMJ Open Sport Exerc. Med. 2, e000178 (2017).","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"89693_CR17","doi-asserted-by":"crossref","unstructured":"Reilly, T. Physiological demands of soccer-implications for training youth. In Youth Sports: Participation, Trainability and Readiness, 2, 163\u2013172 (2016).","DOI":"10.14195\/978-989-26-1171-6_11"},{"key":"89693_CR18","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s40279-016-0476-2","volume":"46","author":"T Rees","year":"2016","unstructured":"Rees, T. et al. The great British medalists project: A review of current knowledge on the development of the world\u2019s best sporting talent. Sports Med. 46, 1041\u20131058 (2016).","journal-title":"Sports Med."},{"key":"89693_CR19","doi-asserted-by":"publisher","first-page":"e0240135","DOI":"10.1371\/journal.pone.0240135","volume":"15","author":"A Altarriba-Bartes","year":"2020","unstructured":"Altarriba-Bartes, A., Pe\u00f1a, J., Vicens-Bordas, J., Mil\u00e0-Villaroel, R. & Calleja-Gonz\u00e1lez, J. Post-competition recovery strategies in elite male soccer players. Effects on performance: A systematic review and meta-analysis. PLoS ONE 15, e0240135 (2020).","journal-title":"PLoS ONE"},{"key":"89693_CR20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s40279-019-01220-8","volume":"50","author":"JL Fox","year":"2020","unstructured":"Fox, J. L., Scanlan, A. T., Stanton, R. & Sargent, C. Insufficient sleep in young athletes? Causes, consequences, and potential treatments. Sports Med. 50, 461\u2013470 (2020).","journal-title":"Sports Med."},{"key":"89693_CR21","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1080\/17461391.2018.1536171","volume":"19","author":"CM Whitworth-Turner","year":"2019","unstructured":"Whitworth-Turner, C. M., Di Michele, R., Muir, I., Gregson, W. & Drust, B. Training load and schedule are important determinants of sleep behaviours in youth-soccer players. Eur. J. Sport Sci. 19, 576\u2013584 (2019).","journal-title":"Eur. J. Sport Sci."},{"key":"89693_CR22","doi-asserted-by":"publisher","first-page":"e12811","DOI":"10.1111\/jsr.12811","volume":"28","author":"M Adelantado-Renau","year":"2019","unstructured":"Adelantado-Renau, M. et al. Associations between objectively measured and self-reported sleep with academic and cognitive performance in adolescents: DADOS study. J. Sleep Res. 28, e12811 (2019).","journal-title":"J. Sleep Res."},{"key":"89693_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/24733938.2017.1366040","volume":"2","author":"C Whitworth-Turner","year":"2018","unstructured":"Whitworth-Turner, C., Di Michele, R., Muir, I., Gregson, W. & Drust, B. A comparison of sleep patterns in youth soccer players and non-athletes. Sci. Med. Footb. 2, 3\u20138 (2018).","journal-title":"Sci. Med. Footb."},{"key":"89693_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s40279-014-0147-0","volume":"44","author":"SL Halson","year":"2014","unstructured":"Halson, S. L. Sleep in elite athletes and nutritional interventions to enhance sleep. Sports Med. 44, 13\u201323 (2014).","journal-title":"Sports Med."},{"key":"89693_CR25","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1136\/bjsports-2020-102025","volume":"55","author":"NP Walsh","year":"2020","unstructured":"Walsh, N. P. et al. Sleep and the athlete: Narrative review and 2021 expert consensus recommendations. Br. J. Sports Med. 55, 356\u2013368 (2020).","journal-title":"Br. J. Sports Med."},{"key":"89693_CR26","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1080\/02640414.2018.1461337","volume":"36","author":"T Sawczuk","year":"2018","unstructured":"Sawczuk, T., Jones, B., Scantlebury, S. & Till, K. The influence of training load, exposure to match play and sleep duration on daily wellbeing measures in youth athletes. J. Sports Sci. 36, 2431\u20132437 (2018).","journal-title":"J. Sports Sci."},{"key":"89693_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/OAJSM.S96821","volume":"7","author":"TM Sabato","year":"2016","unstructured":"Sabato, T. M., Walch, T. J. & Caine, D. J. The elite young athlete: Strategies to ensure physical and emotional health. Open Access J. Sports Med. 7, 99 (2016).","journal-title":"Open Access J. Sports Med."},{"key":"89693_CR28","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1080\/02640414.2014.926382","volume":"32","author":"PB J\u00fadice","year":"2014","unstructured":"J\u00fadice, P. B., Silva, A. M., Magalh\u00e3es, J. P., Matias, C. N. & Sardinha, L. B. Sedentary behaviour and adiposity in elite athletes. J. Sports Sci. 32, 1760\u20131767 (2014).","journal-title":"J. Sports Sci."},{"key":"89693_CR29","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1152\/japplphysiol.00968.2018","volume":"126","author":"JD Akins","year":"2019","unstructured":"Akins, J. D. et al. Inactivity induces resistance to the metabolic benefits following acute exercise. J. Appl. Physiol. (Bethesda, Md.: 1985) 126, 1088\u20131094. https:\/\/doi.org\/10.1152\/japplphysiol.00968.2018 (2019).","journal-title":"J. Appl. Physiol. (Bethesda, Md.: 1985)"},{"key":"89693_CR30","doi-asserted-by":"publisher","first-page":"e20152743","DOI":"10.1542\/peds.2015-2743","volume":"137","author":"MJ Mullender-Wijnsma","year":"2016","unstructured":"Mullender-Wijnsma, M. J. et al. Physically active math and language lessons improve academic achievement: A cluster randomized controlled trial. Pediatrics 137, e20152743. https:\/\/doi.org\/10.1542\/peds.2015-2743 (2016).","journal-title":"Pediatrics"},{"key":"89693_CR31","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","volume":"54","author":"FC Bull","year":"2020","unstructured":"Bull, F. C. et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br. J. Sports Med. 54, 1451\u20131462 (2020).","journal-title":"Br. J. Sports Med."},{"key":"89693_CR32","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/15438627.2017.1393754","volume":"26","author":"H Folgado","year":"2018","unstructured":"Folgado, H., Gon\u00e7alves, B. & Sampaio, J. Positional synchronization affects physical and physiological responses to preseason in professional football (soccer). Res. Sports Med. 26, 51\u201363. https:\/\/doi.org\/10.1080\/15438627.2017.1393754 (2018).","journal-title":"Res. Sports Med."},{"key":"89693_CR33","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1080\/02640414.2010.521168","volume":"28","author":"D Casamichana","year":"2010","unstructured":"Casamichana, D. & Castellano, J. Time\u2013motion, heart rate, perceptual and motor behaviour demands in small-sides soccer games: Effects of pitch size. J. Sports Sci. 28, 1615\u20131623 (2010).","journal-title":"J. Sports Sci."},{"key":"89693_CR34","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s40279-014-0253-z","volume":"44","author":"SL Halson","year":"2014","unstructured":"Halson, S. L. Monitoring training load to understand fatigue in athletes. Sports Med. 44, 139\u2013147 (2014).","journal-title":"Sports Med."},{"key":"89693_CR35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3109\/07420528.2015.1118384","volume":"33","author":"S K\u00f6lling","year":"2016","unstructured":"K\u00f6lling, S. et al. The longer the better: Sleep\u2013wake patterns during preparation of the world rowing junior championships. Chronobiol. Int. 33, 73\u201384 (2016).","journal-title":"Chronobiol. Int."},{"key":"89693_CR36","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1080\/02640414.2019.1661938","volume":"37","author":"JA Vitale","year":"2019","unstructured":"Vitale, J. A., La Torre, A., Banfi, G. & Bonato, M. Acute sleep hygiene strategy improves objective sleep latency following a late-evening soccer-specific training session: A randomized controlled trial. J. Sports Sci. 37, 2711\u20132719 (2019).","journal-title":"J. Sports Sci."},{"key":"89693_CR37","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"WM Association","year":"2013","unstructured":"Association, W. M. World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA 310, 2191\u20132194 (2013).","journal-title":"JAMA"},{"key":"89693_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/17461391.2012.732614","volume":"14","author":"M Romanzini","year":"2014","unstructured":"Romanzini, M., Petroski, E. L., Ohara, D., Dourado, A. C. & Reichert, F. F. Calibration of ActiGraph GT3X, Actical and RT3 accelerometers in adolescents. Eur. J. Sport Sci. 14, 91\u201399 (2014).","journal-title":"Eur. J. Sport Sci."},{"key":"89693_CR39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2466\/pms.1997.85.1.207","volume":"85","author":"G Jean-Louis","year":"1997","unstructured":"Jean-Louis, G. et al. The actigraph data analysis software: I. A novel approach to scoring and interpreting sleep-wake activity. Percept. Mot. Skills 85, 207\u2013216 (1997).","journal-title":"Percept. Mot. Skills"},{"key":"89693_CR40","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/sleep\/17.3.201","volume":"17","author":"A Sadeh","year":"1994","unstructured":"Sadeh, A., Sharkey, M. & Carskadon, M. A. Activity-based sleep\u2013wake identification: An empirical test of methodological issues. Sleep 17, 201\u2013207 (1994).","journal-title":"Sleep"},{"key":"89693_CR41","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3389\/fpsyt.2019.00958","volume":"10","author":"C Smith","year":"2020","unstructured":"Smith, C., Galland, B., Taylor, R. & Meredith-Jones, K. ActiGraph GT3X+ and Actical wrist and hip worn accelerometers for sleep and wake indices in young children using an automated algorithm: Validation with polysomnography. Front. Psychiatry. 10, 958 (2020).","journal-title":"Front. Psychiatry."},{"key":"89693_CR42","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1519\/JSC.0000000000002778","volume":"32","author":"M Beato","year":"2018","unstructured":"Beato, M., Devereux, G. & Stiff, A. Validity and reliability of global positioning system units (STATSports Viper) for measuring distance and peak speed in sports. J. Strength Cond. Res. 32, 2831\u20132837 (2018).","journal-title":"J. Strength Cond. Res."},{"key":"89693_CR43","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1519\/JSC.0b013e3181e72709","volume":"24","author":"C Castagna","year":"2010","unstructured":"Castagna, C., Manzi, V., Impellizzeri, F., Weston, M. & Alvarez, J. C. B. Relationship between endurance field tests and match performance in young soccer players. J. Strength Cond. Res. 24, 3227\u20133233 (2010).","journal-title":"J. Strength Cond. Res."},{"key":"89693_CR44","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1123\/ijspp.2013-0390","volume":"9","author":"JD Ade","year":"2014","unstructured":"Ade, J. D., Harley, J. A. & Bradley, P. S. Physiological response, time\u2013motion characteristics, and reproducibility of various speed-endurance drills in elite youth soccer players: Small-sided games versus generic running. Int. J. Sports Physiol. Perform. 9, 471\u2013479 (2014).","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"89693_CR45","unstructured":"Hill, T., Lewicki, P. & Lewicki, P. Statistics: Methods and Applications: A Comprehensive Reference for Science, Industry, and Data Mining. (StatSoft, Inc., 2006)."},{"key":"89693_CR46","doi-asserted-by":"publisher","first-page":"5","DOI":"10.20982\/tqmp.07.1.p005","volume":"7","author":"L Doey","year":"2011","unstructured":"Doey, L. & Kurta, J. Correspondence analysis applied to psychological research. Tutor. Quant. Methods Psychol. 7, 5\u201314 (2011).","journal-title":"Tutor. Quant. Methods Psychol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-89693-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-89693-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-89693-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T17:57:24Z","timestamp":1699034244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-89693-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,13]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["89693"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-89693-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,13]]},"assertion":[{"value":"7 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10219"}}