{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:46:27Z","timestamp":1776444387932,"version":"3.51.2"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Onychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often affects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations\u2014Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identified in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (<jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Aspergillus niger<\/jats:italic>) and three clinical fungal isolates from Hospital patients (<jats:italic>Candida parapsilosis<\/jats:italic>, <jats:italic>Trichophyton interdigitale<\/jats:italic>, and <jats:italic>Trichophyton rubrum<\/jats:italic>) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a non-negligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic effects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.<\/jats:p>","DOI":"10.1038\/s41598-021-92111-4","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T10:03:09Z","timestamp":1623924189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions"],"prefix":"10.1038","volume":"11","author":[{"given":"Vasco","family":"Silva-Neves","sequence":"first","affiliation":[]},{"given":"Vitor","family":"Hugo","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Costa","family":"Amado","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Pais-Vieira","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Cerqueira","sequence":"additional","affiliation":[]},{"given":"Eug\u00e9nia","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Pais-Vieira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"92111_CR1","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1111\/jdv.12323","volume":"28","author":"B Sigurgeirsson","year":"2014","unstructured":"Sigurgeirsson, B. & Baran, R. The prevalence of onychomycosis in the global population\u2014A literature study. Eur. Acad. Dermatol. Venereol. 28, 1480\u20131491 (2014).","journal-title":"Eur. Acad. Dermatol. Venereol."},{"key":"92111_CR2","volume-title":"Antibiotic and Antifungal Therapies in Dermatology","author":"B Sigurgeirsson","year":"2016","unstructured":"Sigurgeirsson, B. Onychomycosis, chapter 10. In Antibiotic and Antifungal Therapies in Dermatology (eds \u00d3lafsson, J. H. & Hay, R. J.) (Springer International Publishing, 2016)."},{"key":"92111_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.riam.2012.09.007","volume":"30","author":"H Parada","year":"2013","unstructured":"Parada, H. et al. Dermatomycosis in lower limbs of diabetic patients followed by podiatry consultation. Rev. Iberoam. Micol. 30, 103\u2013108 (2013).","journal-title":"Rev. Iberoam. 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United States patent US2020\/0147011 A1. 2020 May 14."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92111-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92111-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92111-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T10:09:44Z","timestamp":1670062184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92111-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["92111"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-92111-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,17]]},"assertion":[{"value":"14 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12789"}}