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Twenty-four human mandibular incisors were pair-matched by micro-computed tomography according to volume and aspect ratio. After retreatment, specimens were allocated to two experimental groups (n\u2009=\u200912), according to the supplementary instrument used. The volume of residual filling material after each irrigating step and the time for retreatment was calculated. Statistical analyses were carried out using Mann\u2013Whitney test, with a significance level of 5%. The volume of initial root canal filling material between the groups was similar (p\u2009&gt;\u20090.05). With the final irrigation protocol (NaOCl and EDTA) the volume of the filling remnants decreased significantly (p\u2009&lt;\u20090.05) with no differences between IrriSafe or XP-endo Finisher R (p\u2009&gt;\u20090.05). The additional solvent mixture MEK\/TCE increased the efficiency of filling materials reduction, regardless of the agitating instruments employed, IrriSafe or XP-endo Finisher R (p\u2009&lt;\u20090.05). There was no difference between the two groups regarding the time (p\u2009=\u20090.149). Both supplementary instruments were effective in the reduction of filling remnants. The additional step with a solvent mixture of MEK\/TCE enabled a total recovery of patency and the achievement of cleaner canals, independently of the agitation instrument.<\/jats:p>","DOI":"10.1038\/s41598-021-92175-2","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:03:04Z","timestamp":1623837784000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Supplementary solvent irrigation efficacy on filling remnants removal comparing XP-endo Finisher R vs IrriSafe"],"prefix":"10.1038","volume":"11","author":[{"given":"In\u00eas","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Pedro S.","family":"Babo","sequence":"additional","affiliation":[]},{"given":"Ana Cristina","family":"Braga","sequence":"additional","affiliation":[]},{"given":"Maria Ascens\u00e3o","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Manuela E.","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Irene","family":"Pina-Vaz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"92175_CR1","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.joen.2020.07.007","volume":"46","author":"A Jakovljevic","year":"2020","unstructured":"Jakovljevic, A. et al. 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