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To understand whether exercise-field tests identify patients who desaturate (SpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200990%) during physical activities, this study compared the six-minute walk test (6MWT) and daily-life telemonitoring. Cross-sectional study including 100 patients referred for pulmonary rehabilitation. The 6MWT was performed in hospital with continuous assessment of SpO<jats:sub>2<\/jats:sub>, HR, walked distance and calculated metabolic equivalent of tasks (METs). Patients were also evaluated in real-life by SMARTREAB telemonitoring, a combined oximetry-accelerometery with remote continuous assessment of SpO<jats:sub>2<\/jats:sub>, HR and METs. SMARTREAB telemonitoring identified 24% more desaturators compared with the 6MWT. Moreover, there were significant mean differences between 6MWT and SMARTREAB in lowest SpO<jats:sub>2<\/jats:sub> of 7.2\u2009\u00b1\u20098.4% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005), in peak HR of \u2212\u20099.3\u2009\u00b1\u200915.5% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005) and also in activity intensity of \u2212\u20090.3\u2009\u00b1\u20090.8 METs (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005). The 6MWT underestimates the proportion of patients with exercise-induced oxygen desaturation compared to real-life telemonitoring. These results help defining oximetry-guided interventions, such as telemedicine algorithms, oxygen therapy titration and regular physical activity assessment in pulmonary rehabilitation.<\/jats:p>","DOI":"10.1038\/s41598-021-96060-w","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T10:03:52Z","timestamp":1629108232000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Telemonitoring of daily activities compared to the six-minute walk test further completes the puzzle of oximetry-guided interventions"],"prefix":"10.1038","volume":"11","author":[{"given":"Catarina Duarte","family":"Santos","sequence":"first","affiliation":[]},{"given":"Ana Filipe","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Rui C\u00e9sar","family":"das Neves","sequence":"additional","affiliation":[]},{"given":"Ruy M.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia","family":"Caneiras","sequence":"additional","affiliation":[]},{"given":"Martijn A.","family":"Spruit","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"B\u00e1rbara","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"96060_CR1","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1164\/rccm.201309-1634ST","volume":"188","author":"MA Spruit","year":"2013","unstructured":"Spruit, M. 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